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Nicotine induces apoptosis in TM3 mouse Leydig cells.

Abstract：

OBJECTIVE:To investigate whether nicotine-induced testicular toxicity involves the induction of apoptosis in Leydig cells. DESIGN:Cell study using cells of the TM3 cell line derived from mouse Leydig cells. SETTING:Academic research laboratory. INTERVENTION(S):Morphological and biochemical analyses for the detection of apoptosis. MAIN OUTCOME MEASURE(S):The effect of nicotine on the occurrence of apoptosis was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, 4,6-diamidino-2-phenylindole staining, terminal deoxynuclotidyl transferase-mediated dUTP nick end labeling assay, DNA fragmentation assay, reverse transcription-polymerase chain reaction, caspase-3 enzyme assay, and Western blot analysis. Nicotine treatment exhibits several features of apoptosis in mouse Leydig cells. RESULT(S):TM3 cells treated with nicotine exhibit several features of apoptosis. It was also shown that nicotine increases the mRNA level of bax and decreases that of bcl-2. In addition, nicotine enhanced the expression of the activated form of caspase-3 and caspase-3 enzyme activity. CONCLUSION(S):Nicotine appears to activate specific intracellular death-related pathways, probably by bax-dependent activation of caspase-3, inducing apoptosis in Leydig cells. Thus, nicotine-induced apoptosis of Leydig cells might be one of the important mechanisms behind nicotine-related urogenital disorders in men.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kim KH,Joo KJ,Park HJ,Kwon CH,Jang MH,Kim CJ

doi

10.1016/j.fertnstert.2004.12.013

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

1093-9

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(04)03205-4

journal_volume

83 Suppl 1

pub_type

杂志文章

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