当前位置： SCI文献检索 > TOXICOLOGY期刊下所有文献 > Blockade of haem oxygenase and nitric oxide synthetase causes cortical dysfunction in sheep exposed to carbon monoxide.

Blockade of haem oxygenase and nitric oxide synthetase causes cortical dysfunction in sheep exposed to carbon monoxide.

Abstract：

:Twenty adult ewes underwent common surgery and following recovery were exposed to 1% carbon monoxide (CO) for 2 h. Ten of these sheep were randomly selected for treatment with haem oxygenase (HO) and nitric oxide synthetase (NOS) blockers. All sheep were killed 5 days later. The CO exposure was narcotic and EEG frequency was suppressed. The EEG recovery was rapid in the control sheep and both slow and incomplete in the treated sheep. This difference was statistically significant (P<0.05). For the first time in our CO studies in sheep, one showed multiple cortical infarcts. This sheep was blocked for HO and NOS function. No significant differences were seen in peri-ventricular white matter infarction distribution and frequency. We have previously shown brain protection against CO- and inert diluent-hypoxemia by way of an increase in brain blood flow (BBF) that maintains adequate brain O2 uptake, and by an increase in circulating red blood cells. From this study, we propose that the induction of neuronal and glial HO and NOS in sheep exposed to CO is protective, especially for the cortex. We intend to study this further by both selective and collective enzyme blockade and by measuring regional BBF changes.

journal_name

Toxicology

journal_title

Toxicology

authors

Gorman D,Lin HY,Williams C

doi

10.1016/j.tox.2004.12.033

keywords:

subject

Has Abstract

pub_date

2005-05-05 00:00:00

pages

237-43

issue

3

eissn

0300-483X

issn

1879-3185

pii

S0300-483X(05)00014-4

journal_volume

209

pub_type

杂志文章

相关文献

TOXICOLOGY文献大全
  • Insights into a basis for incomplete inhibition by botulinum toxin A of Ca2+-evoked exocytosis from permeabilised chromaffin cells.

    abstract：:Inhibition of regulated exocytosis by botulinum toxins type A and B was studied in chromaffin cells. Both virtually abolished catecholamine release triggered from intact cells by depolarising stimuli, whereas the blockade by type A, but not B, was only partial after cell permeabilisation and direct stimulation of exoc...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(02)00453-5

    authors： Lawrence GW,Foran P,Oliver Dolly J

    更新日期：2002-12-27 00:00:00

  • Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca²⁺ and GTPγS.

    abstract：:Clostridium difficile toxins A and B (TcdA and TcdB) belong to the class of large clostridial cytotoxins and inactivate by glucosylation some low molecular mass GTPases of the Rho-family (predominantly Rho, Rac and Cdc42), known as regulators of the actin cytoskeleton. TcdA and B also represent the main virulence fact...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2014.12.006

    authors： Balletta A,Lorenz D,Rummel A,Gerhard R,Bigalke H,Wegner F

    更新日期：2015-02-03 00:00:00

  • Effect of thimerosal, a preservative in vaccines, on intracellular Ca2+ concentration of rat cerebellar neurons.

    abstract：:The effect of thimerosal, an organomercurial preservative in vaccines, on cerebellar neurons dissociated from 2-week-old rats was compared with those of methylmercury using a flow cytometer with appropriate fluorescent dyes. Thimerosal and methylmercury at concentrations ranging from 0.3 to 10 microM increased the int...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2003.09.002

    authors： Ueha-Ishibashi T,Oyama Y,Nakao H,Umebayashi C,Nishizaki Y,Tatsuishi T,Iwase K,Murao K,Seo H

    更新日期：2004-01-15 00:00:00

  • Induction and inhibition of cytochrome P-450-dependent monooxygenases in hamster tissues by ethanol.

    abstract：:The effects of ethanol on hamster hepatic and extrahepatic monooxygenases were determined in the present study. Chronic ethanol administration increased cytochrome P-450 (P-450) content and monooxygenase activities towards aniline, N-nitrosodimethylamine, and 7-ethoxyresorufin. In contrast, benzphetamine and benzo(a)p...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(93)90006-e

    authors： Ueng TH,Ueng YF,Tsai JN,Chao IC,Chen TL,Park SS,Iwasaki M,Guengerich FP

    更新日期：1993-07-28 00:00:00

  • Genetic polymorphism of CYP2A6 in the German population.

    abstract：:Genetic polymorphism of drug metabolizing enzymes (DME) can lead to severe toxicity or therapeutic failure of pharmacotherapy. Additionally, genetically determined differences in the activity of the metabolic enzymes can increase an individual's susceptibility to certain types of chemically induced cancers and possibl...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-483x(99)00199-7

    authors： Bourian M,Gullstén H,Legrum W

    更新日期：2000-04-03 00:00:00

  • The influence of infusion rate on the acute intravenous toxicity of phytic acid, a calcium-binding agent.

    abstract：:The intravenous toxicity of phytic acid (inositol hexakisphosphate, IHP) has recently become of interest because of the potential for IHP incorporation into red blood cells to achieve a therapeutically useful shift in the hemoglobin-oxygen dissociation curve (Gersonde, K. and Nicolau, C., Blut, 39 (1979) 1). The obser...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(81)90022-6

    authors： Gersonde K,Weiner M

    更新日期：1981-01-01 00:00:00

  • Clotrimazole, an antifungal drug possessing diverse actions, increases the vulnerability to cadmium in lymphocytes dissociated from rat thymus.

    abstract：:Since clotrimazole, known as an antifungal drug, exerts diverse actions on cellular functions, it is expected that clotrimazole can be used for other purposes. This antifungal drug protects the cells overloaded with Ca(2+) by A23187, a calcium ionophore. Therefore, the agent may prevent the cells from death induced by...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2006.09.007

    authors： Oyama TM,Oyama TB,Oyama K,Matsui H,Horimoto K,Nishimura Y,Oyama Y

    更新日期：2006-12-07 00:00:00

  • Mercury exposure induces cytoskeleton disruption and loss of renal function through epigenetic modulation of MMP9 expression.

    abstract：:Mercury is one of the major heavy metal pollutants occurring in elemental, inorganic and organic forms. Due to ban on most inorganic mercury containing products, human exposure to mercury generally occurs as methylmercury (MeHg) by consumption of contaminated fish and other sea food. Animal and epidemiological studies...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2017.05.006

    authors： Khan H,Singh RD,Tiwari R,Gangopadhyay S,Roy SK,Singh D,Srivastava V

    更新日期：2017-07-01 00:00:00

  • Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity.

    abstract：:4-Amino-2,6-dichlorophenol (ADCP) is a potent acute nephrotoxicant in vivo inducing prominent renal corticomedullary necrosis. In vitro, ADCP exposure increases lactate dehydrogenase (LDH) release from rat renal cortical slices at 0.05 mM or greater. The purpose of this study was to examine the ability of antioxidants...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2007.12.014

    authors： Rankin GO,Hong SK,Anestis DK,Ball JG,Valentovic MA

    更新日期：2008-03-12 00:00:00

  • Hydroperoxide-induced nucleotide degradation and adenosine formation in isolated rat cardiomyocytes.

    abstract：:The effect of tert-butyl hydroperoxide (tBH) on the nucleotide level in isolated cardiomyocytes from adult rats was examined. Incubation of myocytes with the hydroperoxide resulted in loss of both ATP and NAD from mitochondria and cytosol. In contrast, only the cytosolic level of NADP was increased. The effect on myoc...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(95)03158-c

    authors： Andersson BS,Vidal RF,Sundberg M,Rajs J,Sótonyi P

    更新日期：1996-01-08 00:00:00

  • Novel phototoxicity assay using human embryonic stem cell-derived retinal pigment epithelial cells.

    abstract：:Some chemicals are harmful in to light-exposed tissues such as skin and eyes. The 3T3 Neutral Red Uptake Phototoxicity Test has been validated and adopted by the Organization of Economic and Community Development (OECD) as a method of evaluating chemical phototoxicity using mouse 3T3 fibroblasts. However, the high rat...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2017.01.003

    authors： Mori T,Higashi K,Nakano T,Ando S,Kuwahara A,Suzuki N,Saito K

    更新日期：2017-03-01 00:00:00

  • The selective cytotoxicity of the alkenyl glucosinolate hydrolysis products and their presence in Brassica vegetables.

    abstract：:Cruciferous vegetable consumption correlates with reduced risk of cancer. This chemopreventative activity may involve glucosinolates and their hydrolysis products. Glucosinolate-derived isothiocyanates have been studied for their toxicity and chemopreventative properties, but other hydrolysis products (epithionitriles...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2015.06.002

    authors： Kadir NH,David R,Rossiter JT,Gooderham NJ

    更新日期：2015-08-06 00:00:00

  • The cytolytic toxin aerolysin: from the soluble form to the transmembrane channel.

    abstract：:Aerolysin is a cytolytic toxin which forms channels in the plasma membranes of eucaryotic cells. The protein is secreted by Aeromonas hydrophila as an inactive protoxin. Its stability and water solubility are conferred by its ability to dimerize. Maturation of the protein occurs through proteolytic removal of a C-term...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/0300-483x(94)90152-x

    authors： van der Goot FG,Pattus F,Parker M,Buckley JT

    更新日期：1994-02-28 00:00:00

  • Polycyclic aromatic hydrocarbons in binary mixtures modulate the efficiency of benzo[a]pyrene to form DNA adducts in human cells.

    abstract：:Exposure to polycyclic aromatic hydrocarbons (PAHs) always involves complex mixtures that may induce synergistic or antagonistic effects on the genotoxic properties and make risk assessment more difficult. In this study, we evaluated how particulate PAHs modulated the formation of DNA damage induced by carcinogenic be...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2010.09.002

    authors： Tarantini A,Maître A,Lefèbvre E,Marques M,Rajhi A,Douki T

    更新日期：2011-01-11 00:00:00

  • BALB/c mice orally pretreated with diclofenac have augmented and accelerated PLNA responses to diclofenac.

    abstract：:The nonsteroidal anti-inflammatory drug (NSAID) diclofenac (DF) is associated with idiosyncratic hepatotoxicity and several other distinct hypersensitivity reactions. The mechanism(s) are unknown but evidence suggests both cell-mediated and antibody-mediated immune effector systems may be involved. In the present stud...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(02)00008-2

    authors： Gutting BW,Updyke LW,Amacher DE

    更新日期：2002-04-02 00:00:00

  • Sciatic nerve neuropathy target esterase. Methods of assay, proximo-distal distribution and regeneration.

    abstract：:Some organophosphorus compounds (OP) induce a delayed polyneuropathy (OPIDP) which is initiated by the phosphorylation of the so-called neuropathy target esterase (NTE). In this work some aspects of hen sciatic nerve NTE are studied. The assay method is reported and modifications are discussed and a combined method pr...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(88)90181-3

    authors： Barril JB,Vilanova E,Pellin MC

    更新日期：1988-04-01 00:00:00

  • Effects of o-aminoazotoluene on liver regeneration and p53 activation in mice susceptible and resistant to hepatocarcinogenesis.

    abstract：:The susceptibility to hepatocellular carcinoma (HCC) varies greatly within human populations in response to environmental risk agents. The mechanisms underlying differential susceptibility are still largely unknown and need to be clarified to improve HCC chemoprevention and therapeutic treatment. Inbred rodent strains...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2008.09.013

    authors： Timofeeva OA,Eremeev AV,Goloshchapov A,Kalashnikova E,Ilnitskaya S,Setkov NA,Kobzev V,Buzard GS,Filipenko ML,Kaledin VI,Merkulova TI

    更新日期：2008-12-05 00:00:00

  • Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-β1 pathway in the lung of rats.

    abstract：:In a Japanese chemical factory, a lung disease like pneumoconiosis appeared at a high rate among workers handling cross-linked water-soluble acrylic acid polymer (CWAAP). To our knowledge, no such case was known in the world until very recently. The present study was designed to elucidate the effect of single intratra...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2020.152647

    authors： Suka M,Kido T,Yoshioka W,Hachisuka E,Okoshi H,Yamauchi T,Hano H,Okano T,Yokoyama M,Yanagisawa H

    更新日期：2021-01-30 00:00:00

  • Cholinesterase and phenyl valerate-esterase activities sensitive to organophosphorus compounds in membranes of chicken brain.

    abstract：:Some effects of organophosphorus compounds (OPs) esters cannot be explained by action on currently recognized targets acetylcholinesterase or neuropathy target esterase (NTE). In previous studies, in membrane chicken brain fractions, four components (EPα, EPβ, EPγ and EPδ) of phenyl valerate esterase activity (PVase) ...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2018.08.018

    authors： Estévez J,Benabent M,Selva V,Mangas I,Sogorb MÁ,Del Rio E,Vilanova E

    更新日期：2018-12-01 00:00:00

  • p38 Mitogen-activated protein kinase up-regulates LPS-induced NF-kappaB activation in the development of lung injury and RAW 264.7 macrophages.

    abstract：:Clarification of the key regulatory steps that lead to nuclear factor-kappa B (NF-kappaB) under cellular and pathological conditions is very important. The action of p38 mitogen-activated protein kinase (MAPK) on the upstream of NF-kappaB activation remains controversial. To examine this issue using an in vivo lung in...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2006.04.053

    authors： Kim HJ,Lee HS,Chong YH,Kang JL

    更新日期：2006-08-01 00:00:00

  • Lung function and airway inflammation in rats following exposure to combustion products of carbon-graphite/epoxy composite material: comparison to a rodent model of acute lung injury.

    abstract：:Pulmonary function and inflammation in the lungs of rodents exposed by inhalation to carbon/graphite/epoxy advanced composite material (ACM) combustion products were compared to that of a rodent model of acute lung injury (ALI) produced by pneumotoxic paraquat dichloride. This investigation was undertaken to determine...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/s0300-483x(02)00542-5

    authors： Whitehead GS,Grasman KA,Kimmel EC

    更新日期：2003-02-01 00:00:00

  • Effects of amiodarone administration during pregnancy in Fischer 344 rats.

    abstract：:Amiodarone is a class III anti-arrhythmic compound that is iodinated, cationic and amphiphilic in nature. The clinical use of amiodarone may be associated with various side-effects, including pulmonary and hepatic toxicity. Use of this compound during pregnancy may therefore place the fetus at risk through in utero ex...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(91)90085-f

    authors： Hill DA,Reasor MJ

    更新日期：1991-01-01 00:00:00

  • Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung.

    abstract：:To investigate mechanisms of chemical-induced congenital heart defects (CHD) we have developed a rat model using dimethadione (DMO), the N-demethylated metabolite of the anticonvulsant, trimethadione (TMD). Dosing pregnant rats with 300mg/kg DMO every 12h from the evening of gestational day (GD) 8 until the morning of...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2014.10.014

    authors： Rodger I,Lam I,Purssell E,Thompson M,Rutter A,Ozolinš TR

    更新日期：2014-12-04 00:00:00

  • Comparative in vitro study of the inhibition of human and hen esterases by methamidophos enantiomers.

    abstract：:The current Organisation for Economic Co-operation and Development (OECD) guidelines for evaluating organophosphorus-induced delayed neuropathy (OPIDN) require the observation of dosed animals over several days and the sacrifice of 48 hens. Adhering to these protocols in tests with enantiomers is difficult because lar...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2011.12.004

    authors： Emerick GL,DeOliveira GH,Oliveira RV,Ehrich M

    更新日期：2012-02-26 00:00:00

  • Lead-induced inclusion bodies in rat kidney after perinatal treatment with lead and disulfiram.

    abstract：:The presence of inclusion bodies in renal proximal tubules was studied in rats exposed to lead and/or disulfiram (tetraethylthiuram disulfide). Pregnant rats were treated with only lead acetate (0.25% Pb in the drinking water), only disulfiram (0.1 mmol/kg p.o. twice a week) or with both lead acetate and disulfiram fr...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(87)90046-1

    authors： Oskarsson A,Johansson A

    更新日期：1987-04-01 00:00:00

  • Dose-dependent reversal of acute murine colchicine poisoning by goat colchicine-specific Fab fragments.

    abstract：:The use of colchicine-specific Fab fragments is of interest in human poisoning. In the present study, we show the efficacy of Fab fragments in reversing colchicine toxicity in mice. High affinity antibodies (Ka = 2 x 10(10) M-1) against colchicine were raised in goats; Fab fragments were purified by DEAE chromatograph...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(91)90015-s

    authors： Sabouraud A,Urtizberea M,Grandgeorge M,Gattel P,Makula ME,Scherrmann JM

    更新日期：1991-01-01 00:00:00

  • Diet and prostate cancer.

    abstract：:The importance of dietary factors for prostate carcinogenesis has been proven by epidemiological studies of immigrants from Asia into the USA. Intake of foodstuffs rich in fat, including meat, is suggested to be a risk factor. Experimentally, while some studies demonstrated high fat intake to promote rat prostate carc...

    journal_title：Toxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0300-483x(02)00260-3

    authors： Shirai T,Asamoto M,Takahashi S,Imaida K

    更新日期：2002-12-27 00:00:00

  • Ozone exposure promotes pyroptosis in rat lungs via the TLR2/4-NF-κB-NLRP3 signaling pathway.

    abstract：OBJECTIVE:Ozone has become a major air pollutant in recent years, which leading to a variety of lung diseases. This study aimed to explore the mechanisms of pyroptosis and related signaling pathways in ozone-induced lung injury. METHODS:We exposed 120 Wistar rats to ozone, 20 in each group (half male and half female)....

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2020.152668

    authors： Tian L,Yan J,Li K,Zhang W,Lin B,Lai W,Bian L,Liu H,Xi Z,Liu X

    更新日期：2020-12-28 00:00:00

  • NAD+ and NADH in brain cortex from mice exposed to high oxygen pressure.

    abstract：:Experiments were done in vivo to determine the effect of oxygen at high pressure (OHP) on NAD+ and NADH in mouse brain cortex. A 7% decrease (N.S.) in NADH was found in brain cortex from mice exposed to 6 atm of 100% oxygen for 8 min, while a 20% decrease (P less than 0.01) in cortical NADH, when compared to controls,...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/0300-483x(82)90014-2

    authors： Dodd DE,Faiman MD

    更新日期：1982-01-01 00:00:00

  • Different reactivity of primary fibroblasts and endothelial cells towards crystalline silica: A surface radical matter.

    abstract：:Quartz is a well-known occupational fibrogenic agent able to cause fibrosis and other severe pulmonary diseases such as silicosis and lung cancer. The silicotic pathology owes its severity to the structural and chemo-physical properties of the particles such as shape, size and abundance of surface radicals. In earlier...

    journal_title：Toxicology

    pub_type： 杂志文章

    doi：10.1016/j.tox.2016.07.001

    authors： Pozzolini M,Vergani L,Ragazzoni M,Delpiano L,Grasselli E,Voci A,Giovine M,Scarfì S

    更新日期：2016-06-15 00:00:00