Analysis of the hypervariable region of the Salmonella enterica genome associated with tRNA(leuX).

Abstract:

:The divergence of Salmonella enterica and Escherichia coli is estimated to have occurred approximately 140 million years ago. Despite this evolutionary distance, the genomes of these two species still share extensive synteny and homology. However, there are significant differences between the two species in terms of genes putatively acquired via various horizontal transfer events. Here we report on the composition and distribution across the Salmonella genus of a chromosomal region designated SPI-10 in Salmonella enterica serovar Typhi and located adjacent to tRNA(leuX). We find that across the Salmonella genus the tRNA(leuX) region is a hypervariable hot spot for horizontal gene transfer; different isolates from the same S. enterica serovar can exhibit significant variation in this region. Many P4 phage, plasmid, and transposable element-associated genes are found adjacent to tRNA(leuX) in both Salmonella and E. coli, suggesting that these mobile genetic elements have played a major role in driving the variability of this region.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Bishop AL,Baker S,Jenks S,Fookes M,Gaora PO,Pickard D,Anjum M,Farrar J,Hien TT,Ivens A,Dougan G

doi

10.1128/JB.187.7.2469-2482.2005

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

2469-82

issue

7

eissn

0021-9193

issn

1098-5530

pii

187/7/2469

journal_volume

187

pub_type

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