Abstract:
:The divergence of Salmonella enterica and Escherichia coli is estimated to have occurred approximately 140 million years ago. Despite this evolutionary distance, the genomes of these two species still share extensive synteny and homology. However, there are significant differences between the two species in terms of genes putatively acquired via various horizontal transfer events. Here we report on the composition and distribution across the Salmonella genus of a chromosomal region designated SPI-10 in Salmonella enterica serovar Typhi and located adjacent to tRNA(leuX). We find that across the Salmonella genus the tRNA(leuX) region is a hypervariable hot spot for horizontal gene transfer; different isolates from the same S. enterica serovar can exhibit significant variation in this region. Many P4 phage, plasmid, and transposable element-associated genes are found adjacent to tRNA(leuX) in both Salmonella and E. coli, suggesting that these mobile genetic elements have played a major role in driving the variability of this region.
journal_name
J Bacterioljournal_title
Journal of bacteriologyauthors
Bishop AL,Baker S,Jenks S,Fookes M,Gaora PO,Pickard D,Anjum M,Farrar J,Hien TT,Ivens A,Dougan Gdoi
10.1128/JB.187.7.2469-2482.2005keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
2469-82issue
7eissn
0021-9193issn
1098-5530pii
187/7/2469journal_volume
187pub_type
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