Functional interaction between APOE4 and LDL receptor isoforms in Alzheimer's disease.

Abstract:

BACKGROUND:Multiple genes have been provisionally associated with Alzheimer's disease, including the coding polymorphisms in exons 8 and 13 in the low density lipoprotein receptor gene (LDLR), situated on chromosome 19p13.2. METHODS:The sample groups consisted of 180 AD patients and 141 control spouses. We carried out genotyping of LDLR8 and LDLR13. RESULTS:The LDLR8 GG genotype was common, found in 84% of the unaffected control subjects and 91% of the AD patients in our study. There was a ninefold elevation in risk associated with GG:CC versus A- and T- among APOE4+ subjects when compared with APOE4- subjects (odds ratio 9.3; 95% confidence interval 1.8 to 48.2). With the additional information on LDLR polymorphism, we defined an overall 12 fold elevation in risk for APOE4 in combination with LDLR GG:CC (11.9; 2.8 to 50.0; Fisher's exact test, p = 0.0002; standard power 0.999), compared with other subjects lacking all three of these polymorphisms. CONCLUSION:These results imply a functional interaction between ApoE and LDL receptor proteins that determines risk for Alzheimer's disease.

journal_name

J Med Genet

authors

Cheng D,Huang R,Lanham IS,Cathcart HM,Howard M,Corder EH,Poduslo SE

doi

10.1136/jmg.2004.024968

keywords:

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

129-31

issue

2

eissn

0022-2593

issn

1468-6244

pii

42/2/129

journal_volume

42

pub_type

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