Abstract:
:The purpose of this study was to evaluate cisplatin-induced ototoxicity and the protective effects of tiopronin. Twenty-four adult Wistar rats served as subjects and were divided into three groups. Eight rats receiving only saline (group A) were used as controls. Eight rats received cisplatin (2 mg/kg) injections (group B) and eight rats received cisplatin and tiopronin (300 mg/kg) (group C) for 8 consecutive days. Both ears of all animals were tested by DPOAE before treatment and on the 4th and 9th days. Seventy-two hours after the final recording session, all animals were killed, and the left cochleas were prepared for electron microscopy and analysed. DPOAE responses were significantly reduced in group B compared to controls (p<0.05). When tiopronin was added, DPOAE responses were significantly increased compared to those obtained with the administration of cisplatin alone (p<0.05). The cochleogram showed that tiopronin had a significant protective effect in the basal half and in the lower half of the middle turn. We conclude that tiopronin, a drug effective in protecting against cisplatin nephrotoxicity, is also effective in protecting against cisplatin ototoxicity.
journal_name
Int J Audioljournal_title
International journal of audiologyauthors
Fetoni AR,Quaranta N,Marchese R,Cadoni G,Paludetti G,Sergi Bdoi
10.1080/14992020400050059keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
465-70issue
8eissn
1499-2027issn
1708-8186journal_volume
43pub_type
杂志文章abstract::The aim of this study was to examine the music exposure and hearing of disc jockeys (DJs). We conducted personal noise dosimetry on 30 DJs and interviewed them regarding their hearing and their job. We conducted pure-tone audiometry, and transient and distortion product otoacoustic emissions before their exposure to m...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020601188575
更新日期:2007-05-01 00:00:00
abstract::The objective of this study was to explore cochlear implant users' speech perception performance in quiet and in noise for low to moderate stimulation rates. Eight postlingually deaf adult users of the Nucleus CI24 cochlear implant (contour electrode array) using the ESPrit 3G speech processor participated in this stu...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020902858967
更新日期:2009-08-01 00:00:00
abstract::The purpose of this research was to investigate the congruent/incongruent perceptions of hearing-loss related quality of life between members of couples and to determine how incongruence was affected by individual psychosocial characteristics, specifically measures of mood (negative affect and positive affect), stress...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992020903311396
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To explore the explanatory power of a self-determination theory (SDT) model of health behaviour change for hearing aid adoption decisions and fitting outcomes. DESIGN:A quantitative approach was taken for this longitudinal cohort study. Participants completed questionnaires adapted from SDT that measured aut...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2015.1120893
更新日期:2016-07-01 00:00:00
abstract::The aim of this study was to compare auditory functions and to analyse the prevalence of hearing impairment and the relationship of self-reported hearing disability with audiometric test results among 75-year-old people in three Nordic localities. The representative samples came from Glostrup, Denmark (n = 571), Göteb...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020500189112
更新日期:2005-09-01 00:00:00
abstract::Tinnitus is poorly reflected by audiometric (cochlear) data, indicating that central nervous system (CNS) components are involved in its development. This study aimed to provide support for the neurophysiological theory of tinnitus as a result of combined peripheral and central nervous dysfunctions. Our main findings ...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992020209077190
更新日期:2002-07-01 00:00:00
abstract::This experiment investigated the effect of small-group versus individual hearing loss prevention (HLP) training on the attenuation performance of passive insert-type hearing protection devices (HPDs). A subject-fit (SF) methodology, which gave naive listeners access only to the instructions printed on the HPD product ...
journal_title:International journal of audiology
pub_type: 杂志文章,随机对照试验
doi:10.1080/14992020701438805
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:The main purpose of this research was to obtain normative data for auditory processing tests for Norwegian speaking children. DESIGN:Participants were administered routine audiological tests and an auditory processing test-battery consisting of Filtered Words, Competing Words, Dichotic Digits, Gaps In Noise,...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2017.1366670
更新日期:2018-01-01 00:00:00
abstract::This paper focuses on the assessment of communication among deaf and hearing persons within work settings. The paper is organized into two sections. In the first section, findings are presented from an ethnographic study of deaf professionals who have achieved relative success in their employment. The results from thi...
journal_title:International journal of audiology
pub_type: 杂志文章,评审
doi:10.3109/14992020309074634
更新日期:2003-07-01 00:00:00
abstract::The reliability of the Auditory Steady State Response (ASSR) has not been thoroughly evaluated despite its recent application as a clinical tool for threshold estimation. The purpose of this study was to examine test-retest (TR) reliability of ASSR threshold estimates in an empirical research design. The ASSR, tested ...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020600753197
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To describe the audiological journey of a group of infants with auditory neuropathy spectrum disorder (ANSD) following the fitting of hearing aids, and to investigate the potential benefits of including cortical auditory-evoked potentials (CAEPs) and a measure of functional auditory behaviour during early aud...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2015.1007214
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To examine the effectiveness of targeted surveillance for the identification of moderate-profound PCHI in babies who pass the newborn hearing screen in England and have risk factors. DESIGN:Retrospective analysis. STUDY SAMPLE:2,307,880 children born 01/04/06-30/09/09 in England. RESULTS:Overall the preval...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2013.769067
更新日期:2013-06-01 00:00:00
abstract::Information regarding typical changes in electrical stimulation levels during different stages post-implantation in children is scarce. Clinically, this information can serve as a general guideline to the nature and frequency of these changes, and consequently help to determine programming schedules that would optimiz...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992020309078346
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To design a test battery and conduct a proof-of-concept experiment of a test method that can be used to measure the detection performance afforded by military advanced hearing protection devices (HPDs) and tactical communication and protective systems (TCAPS). DESIGN:The detection test was conducted with eac...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2016.1256505
更新日期:2017-01-01 00:00:00
abstract::Hearing-aid use in the elderly population is problematic since not all people who would benefit from hearing aids actually obtain one. In this study, the relationship between pre-fitting expectations and willingness to use hearing aids is addressed. One hundred adult hearing aid candidates (mean age 68.6 years) were r...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020701843111
更新日期:2008-04-01 00:00:00
abstract::Confirmation of the conditions of the ossicles is essential for tympanoplasty. However, at present, ossicular mobility is experimentally estimated with palpation by a surgeon, and the results depend on the surgeon's skill. In this study, a new apparatus for quantitatively measuring ossicular mobility was developed. Wi...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020500377899
更新日期:2006-02-01 00:00:00
abstract::The objective of this study was to determine normative values for tympanometric variables for 4-5-year-old children. Tympanometry was performed at a pre-scheduled visit at the age of 49-68 months on children recruited to a follow-up visit in a vaccine efficacy trial (n=756 children). Tympanograms obtained successfully...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992020309101325
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:Hearing loss (HL) affects the everyday functioning of millions of people worldwide. The Brief International Classification of Functioning Disability and Health (ICF) core sets for HL was developed to meet the complex health care needs of adults with HL. Because the brief core set for HL has not yet been valid...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2020.1846088
更新日期:2020-11-18 00:00:00
abstract::The real-ear insertion response (REIR) of a hearing aid is estimated as the difference between the aided response and the unaided response in the ear canal. Changes in the position of the loudspeaker relative to the head, between the two measurements, may reduce the accuracy of the estimate. The spatial variability of...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020400050036
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To determine the influence of choice of prescription and other child-, family- and intervention-related factors on speech, language, and functional performance of hearing-impaired children by three years of age. DESIGN AND STUDY SAMPLE:A randomized controlled design was implemented as part of a population-ba...
journal_title:International journal of audiology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14992027.2012.705903
更新日期:2013-12-01 00:00:00
abstract::The effect of inverting electrode location and stimulus perceptibility on the presence of the mismatch negativity (MMN) evoked response was investigated in 20 normal-hearing adult females. Perceptible and imperceptible frequency contrasts were employed in an oddball paradigm. The perceptible contrast consisted of an 1...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020802283241
更新日期:2008-11-01 00:00:00
abstract::The aim of this study was to evaluate, in 20 young volunteer subjects, the effects of supra-physiological vitamin B12 administration on noise-induced temporary threshold shift (TTS). All subjects had hearing thresholds within 15 dBHL and type A tympanograms. The subjects were randomly assigned to two different groups....
journal_title:International journal of audiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/14992020400050022
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To determine the usage and knowledge of safe limits on personal listening devices (PLD) among college students. DESIGN:First, information on health history was collected. Second, microphone in real ear techniques determined eardrum to free-field correction factors. Third, hearing levels were evaluated and in...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2014.986691
更新日期:2015-06-01 00:00:00
abstract::Tinnitus is a condition that is difficult to treat, and treatment outcomes are difficult to measure The majority of people who experience tinnitus are not troubled by it; however, the troubled minority are referred by an otorhinolaryngologist for specialist clinic help. The aim of this study was to investigate how the...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020400050052
更新日期:2004-07-01 00:00:00
abstract::Objective: To identify any change in quality of life (QoL) caused by chemotherapy-induced toxicities, such as hearing loss and tinnitus, to provide information in order to improve services and aid clinicians in their decision-making. Design: This systematic review followed the preferred reporting items for systematic ...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2019.1660918
更新日期:2019-11-01 00:00:00
abstract::Objective: To create a language independent version of the Listening in Spatialised Noise - Sentences test (LiSN-S) and evaluate it in an English-speaking population.Design: Test development and normative data collection. LiSN-Universal (LiSN-U) targets consisted of CVCV pseudo-words (e.g. /mupa/). Two looped distract...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2019.1689431
更新日期:2020-04-01 00:00:00
abstract::In a laboratory study, we found that normal-hearing and hearing-impaired listeners preferred less than normal overall calculated loudness (according to a loudness model of Moore & Glasberg, 1997). The current study verified those results using a research hearing aid. Fifteen hearing-impaired and eight normal-hearing p...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020500190177
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To evaluate methods for estimating thresholds of vestibular evoked myogenic potentials (VEMPs) and ocular VEMPs (OVEMPs) produced by impulsive transmastoid acceleration (ITA). DESIGN:VEMPs and OVEMPs were obtained simultaneously from subjects in supine posture with both head and eyes elevated. Thresholds to ...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2013.853134
更新日期:2014-02-01 00:00:00
abstract::Objective: To assess the recognition of lexical tones in Mandarin-speaking bimodal cochlear implant (CI) subjects.Design: Lexical tone recognition in quiet and noise (SNR= +5 dB) was measured with electric stimulation (CI alone) or bimodal stimulation (CI + hearing aid (HA)). The recognition and confusion rates of the...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2020.1719437
更新日期:2020-07-01 00:00:00
abstract::The purpose of this study was to determine and to compare the overall intelligibility, articulation, resonance, and voice characteristics in children using cochlear implants (CI) and children using conventional hearing aids (HA). Nine prelingually deaf children using CI and six children with a prelingual severe hearin...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020500189146
更新日期:2005-08-01 00:00:00