The protective role of tiopronin in cisplatin ototoxicity in Wistar rats.

Abstract:

:The purpose of this study was to evaluate cisplatin-induced ototoxicity and the protective effects of tiopronin. Twenty-four adult Wistar rats served as subjects and were divided into three groups. Eight rats receiving only saline (group A) were used as controls. Eight rats received cisplatin (2 mg/kg) injections (group B) and eight rats received cisplatin and tiopronin (300 mg/kg) (group C) for 8 consecutive days. Both ears of all animals were tested by DPOAE before treatment and on the 4th and 9th days. Seventy-two hours after the final recording session, all animals were killed, and the left cochleas were prepared for electron microscopy and analysed. DPOAE responses were significantly reduced in group B compared to controls (p<0.05). When tiopronin was added, DPOAE responses were significantly increased compared to those obtained with the administration of cisplatin alone (p<0.05). The cochleogram showed that tiopronin had a significant protective effect in the basal half and in the lower half of the middle turn. We conclude that tiopronin, a drug effective in protecting against cisplatin nephrotoxicity, is also effective in protecting against cisplatin ototoxicity.

journal_name

Int J Audiol

authors

Fetoni AR,Quaranta N,Marchese R,Cadoni G,Paludetti G,Sergi B

doi

10.1080/14992020400050059

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

465-70

issue

8

eissn

1499-2027

issn

1708-8186

journal_volume

43

pub_type

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