Angiogenesis and anti-angiogenic therapy in myelofibrosis with myeloid metaplasia.

Abstract:

:Myelofibrosis with myeloid metaplasia (MMM) is a clonal stem cell disorder that is characterized by florid bone marrow stromal reaction including collagen fibrosis, osteosclerosis, and angiogenesis. Almost all patients with MMM display increased bone marrow microvessel density (MVD) and the extent is among the highest in hematological malignancies. This particular information has encouraged the therapeutic use of anti-angiogenic drugs in MMM. In the current review, we summarize the general concepts regarding angiogenesis, assessment of angiogenesis in hematological malignancies and then the current literature on angiogenesis and anti-angiogenic therapy in MMM.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Arora B,Mesa R,Tefferi A

doi

10.1080/10428190400003267

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

2373-86

issue

12

eissn

1042-8194

issn

1029-2403

pii

0XMD2TAHMK49VLHR

journal_volume

45

pub_type

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