Babesia divergens and Plasmodium falciparum use common receptors, glycophorins A and B, to invade the human red blood cell.

Abstract:

:Babesiosis has long been recognized as an economically important disease of cattle, but only in the last 30 years has Babesia been recognized as an important pathogen in humans. Invasion of erythrocytes is an integral part of the Babesia life cycle. However, very little information is available on the molecules involved in this process, in contrast to another hemoparasite, Plasmodium falciparum. Using invasion assays into normal red blood cells (RBCs), enzyme-treated cells, and clinically mutant cells, we showed that Babesia divergens uses neuraminidase- and trypsin-sensitive receptors to enter the RBCs, of which glycophorins A and B are the prominent ones. These results could have broad implications relating to evolutionarily conserved mechanisms of host cell entry in these related Apicomplexan parasites and pave the way toward a detailed molecular analysis of erythrocyte invasion in B. divergens.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Lobo CA

doi

10.1128/IAI.73.1.649-651.2005

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

649-51

issue

1

eissn

0019-9567

issn

1098-5522

pii

73/1/649

journal_volume

73

pub_type

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