Anaplastic pleomorphic xanthoastrocytomas. Review of the literature with reference to malignancy potential.

Abstract:

:Malignancy potential of pleomorphic xanthoastrocytomas (PXAs) has rather been an underestimated reality. We report the case of a 13-year-old boy who presented with signs of increased intracranial pressure. The child had been epileptic since the age of 2. Computed tomography and magnetic resonance scans revealed a huge left frontal mass. At surgery, a subtotal excision was accomplished. Histopathological diagnosis was anaplastic PXA (grade III; WHO, 2000). The tumor showed an increased mitotic index and minimal endothelial proliferation. The patient died 3.5 months later due to a fatal intracranial hemorrhage. A review of the entire PXA literature revealed 15 well-documented cases of PXA with subsequent malignant transformation and 11 cases of primary anaplastic PXA. The prognosis was grim for both subsets of patients. Anaplastic PXAs clearly represent the transition between the original PXA concept and lipidized giant-cell glioblastoma.

journal_name

Pediatr Neurosurg

journal_title

Pediatric neurosurgery

authors

Tekkök IH,Sav A

doi

10.1159/000081935

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

171-81

issue

4

eissn

1016-2291

issn

1423-0305

pii

81935

journal_volume

40

pub_type

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