Rfam: annotating non-coding RNAs in complete genomes.

Abstract:

:Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Griffiths-Jones S,Moxon S,Marshall M,Khanna A,Eddy SR,Bateman A

doi

10.1093/nar/gki081

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

D121-4

issue

Database issue

eissn

0305-1048

issn

1362-4962

pii

33/suppl_1/D121

journal_volume

33

pub_type

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