[Assessment of soluble intracellular adhesion molecule-1 (sICAM-1) in women with benign ovarian tumors].

Abstract:

OBJECTIVES:Overexpression of intracellular adhesion molecule-I (ICAM-1) was observed in many benign and malignant tumors. The aim of our study was to evaluate its serum concentrations as well as CA-125 in women with benign ovarian tumors. MATERIALS AND METHODS:Forty-five women treated surgically because of benign ovarian mass. RESULTS:Mean concentrations of sICAM-1 in benign tumors was 241.8+/-74.1 ng/ml and 195.6+/-68.7 ng/ml in healthy controls. No correlations between sICAM-1 concentrations and leukocyte count, tumor volume, BMI and obstetrical history. Efficiency in tumor differentiation was higher for CA-125 than sICAM-1 (area under Receiver Operating Characteristic curve 0.78 and 0.63 respectively). We observed higher sICAM-1 concentrations in fibrothecomas and lower in endometrial and dermoid cysts. CONCLUSIONS:Serum ICAM-1 concentrations correlate with some histological types of benign tumors, but not with tumor volume. Levels of CA-125 are more effective than ICAM-1 in ovarian tumors differentiation.

journal_name

Ginekol Pol

journal_title

Ginekologia polska

authors

Rzymski P,Opala T,Woźniak J,Drews K,Sajdak S

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

785-92

issue

10

eissn

0017-0011

issn

2543-6767

journal_volume

75

pub_type

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