Abstract:
:The few long-term survivors of MPM have been cured with radical surgical extirpation often followed by radiation therapy and adjuvant chemotherapy. The combination of pemetrexed and cisplatin recently was shown to improve survival over treatment with cisplatin alone. Given the size and robustness of that trial, the combination should be the new standard treatment for this cancer. Combined modality approaches to therapy, including surgery, radiation, and chemotherapy, are becoming the standard of care in patients with resectable mesothelioma. Two phase II studies have demonstrated that neoadjuvant chemotherapy is safe and apparently effective. A third phase II trial will use the combination of pemetrexed plus cisplatin preoperatively followed by surgery and radiation for patients with T1-3 N0-2 mesothelioma. If the statistical analysis of this study shows a measurable pathologic complete response rate and a median survival that exceeds the current expected value of 20 to 24 months, a phase III trial comparing surgery and radiation to surgery, radiation, and chemotherapy will be considered.
journal_name
Thorac Surg Clinjournal_title
Thoracic surgery clinicsauthors
Vogelzang NJdoi
10.1016/j.thorsurg.2004.06.010keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
531-42issue
4eissn
1547-4127issn
1558-5069pii
S1547-4127(04)00125-2journal_volume
14pub_type
杂志文章,评审abstract::European studies have contributed significantly to the understanding of lung cancer screening. Smoking within screening, quality of life, nodule management, minimally invasive treatments, cancer prevention programs, and risk models have been extensively investigated by European groups. Mortality data from European scr...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2014.12.002
更新日期:2015-05-01 00:00:00
abstract::The aim of this study is to assess in bronchial carcinoid tumors, the prognostic factors in relation to the histology that would determine their most appropriate therapy. The histologic aggressiveness is a determining factor in tumor size and nodal involvement in these tumors. The knowledge of the histologic limits of...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2014.05.003
更新日期:2014-08-01 00:00:00
abstract::Esophageal perforation has historically been a devastating condition resulting in high morbidity and mortality. The use of endoluminal therapies to treat esophageal leaks and perforations has grown exponentially over the last decade and offers many advantages over traditional surgical intervention in the appropriate c...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2018.07.002
更新日期:2018-11-01 00:00:00
abstract::In spite of numerous clinical trials, the jury is still out on the value of induction therapy for locally advanced lung cancer. We elected to address this topic from the multifaceted views of the clinicians often involved in lung cancer management and according the most recent views on locally advanced NSCLC. The conc...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2011.08.010
更新日期:2012-02-01 00:00:00
abstract::Surgical treatment of idiopathic scoliosis has classically included posterior, anterior, or combined open surgical techniques. In recent years, a videothoracoscopic approach to the spine has been increasingly employed either in combination with the posterior open approach or as a stand-alone treatment including anteri...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2010.01.004
更新日期:2010-05-01 00:00:00
abstract::With appropriate planning and operative technique, the risk of pulmonary artery injury and bleeding during video-assisted thoracoscopic surgery (VATS) lobectomy can be minimized. However, the risk cannot be completely eliminated; surgeons should always ensure that they are prepared to manage this situation if it occur...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2015.04.007
更新日期:2015-08-01 00:00:00
abstract::Gastroesophageal reflux disease (GERD) is a well-defined disease characterized by symptoms or complications caused by an abnormal amount of GER, which is a retrograde movement of gastric contents into the esophagus. Laryngopharyngeal reflux (LPR) is a subset of GERD and given its own identity, because the main symptom...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2011.08.001
更新日期:2011-11-01 00:00:00
abstract::Nonintubated video-assisted thoracoscopic surgery for the treatment of primary and secondary pneumothorax was first reported in 1997 by Nezu. However, studies on this technique are few. Research in the past 20 years has focused on the perioperative outcomes, including the surgical duration, length of hospital stay, an...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2019.08.001
更新日期:2020-02-01 00:00:00
abstract::The National Quality Forum (NQF) is a multistakeholder, nonprofit, membership-based organization improving health care through preferential use of valid performance measures. NQF-endorsed measures are considered the gold standard for health care measurement in the United States. The Society of Thoracic Surgeons is the...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2017.03.003
更新日期:2017-08-01 00:00:00
abstract::Thoracoscopy has afforded a huge advance for upper thoracic sympathetic procedures compared with prior open procedures. Different clinical syndromes of hyperhidrosis exist and require different forms of treatment. The classic severe palmoplantar pattern of hyperhidrosis will not respond effectively in the long term to...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2008.01.005
更新日期:2008-05-01 00:00:00
abstract::Pleural metastasis is a common occurrence in up to 30% of patients with metastatic cancer. When lung entrapment and loculation of fluid occur, treatment is more difficult and we have named this condition "oncothorax." The malignant adhesions that entrap the lung in an oncothorax are not typically amenable to surgical ...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2017.08.009
更新日期:2018-02-01 00:00:00
abstract::The incorporation of research into a career in thoracic surgery is a complex process. Ideally, the preparation for a career in academic thoracic surgery begins with a research fellowship during training. In the academic setting, a research portfolio might include clinical research, translational research, or basic res...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章
doi:10.1016/j.thorsurg.2011.04.004
更新日期:2011-08-01 00:00:00
abstract::Arterial thoracic outlet syndrome is rare and may be associated with a bony anomaly. Patient presentation can range from mild arm discoloration and claudication to severe limb-threatening ischemia. For patients with subclavian artery dilation without secondary complications, thoracic outlet decompression and arterial ...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2020.09.006
更新日期:2021-02-01 00:00:00
abstract::Benign stenosis of trachea results mainly from tracheotomy, ventilation, or trauma. The combination of a defect of the mucosa or the tracheal wall and infection produce secondary scar tissue healing with shrinkage of the tracheal lumen or instability of the tracheal wall. Standard of treatment consists of resection of...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2013.09.001
更新日期:2014-02-01 00:00:00
abstract::Despite advances in treatment, long-term outcomes for esophageal cancer remain poor, with overall survival rates of between 15% and 35%. Poor long-term survival reflects locoregionally advanced disease or metastatic disease at presentation. Among patients undergoing surgical resection, 40% to 50% have stage III diseas...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2013.07.007
更新日期:2013-11-01 00:00:00
abstract::Postoperative pain following thoracic surgery presents a significant challenge, and multiple factors complicate recovery and pain management for this population. Considerable comorbidities often exist in thoracic surgical patients, further limiting therapeutic options. Elements of nociceptive and neuropathic pain may ...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2015.07.005
更新日期:2015-11-01 00:00:00
abstract::The current convention is for bilateral one-stage lung volume reduction surgery. Unilateral surgery results in a symptomatic improvement in most patients. A staged approach to the second lung may reduce the risk of surgery and lead to a slower decline in physiologic improvement. The timing of the second operation can ...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2009.02.001
更新日期:2009-05-01 00:00:00
abstract::The literature shows that, in the hands of experienced thoracoscopic surgeons, VL is a safe operation that offers patients at least comparable complication and survival rates compared with lobectomy by thoracotomy. VL can be performed safely with proven advantages over conventional thoracotomy for lobectomy: smaller i...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2007.03.019
更新日期:2007-05-01 00:00:00
abstract::Esophageal cancer requires a multimodality treatment approach, with surgical resection a key component in many cases. When it comes to esophagectomy, several approaches and techniques exist, including transhiatal versus transthoracic and open versus minimally invasive. Each approach has its associated risks and advant...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2020.04.010
更新日期:2020-08-01 00:00:00
abstract::Nanotechnology is an emerging field with potential as an adjunct to cancer therapy, particularly thoracic surgery. Therapy can be delivered to tumors in a more targeted fashion, with less systemic toxicity. Nanoparticles may aid in diagnosis, preoperative characterization, and intraoperative localization of thoracic t...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2015.12.009
更新日期:2016-05-01 00:00:00
abstract::MPM is an uncommon disease with limited treatment options. Early diagnosis, a standardized staging system, early referral to centers experienced in MPM, and efforts to develop collaborative multicenter trials are essential to improving treatment for patients with MPM. Efforts to manage this malignancy, which is projec...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2004.06.009
更新日期:2004-11-01 00:00:00
abstract::Practically, hiatal hernias are divided into sliding hiatal hernias (type I) and PEH (types II, III, or IV). Patients with PEH are usually symptomatic with GERD or obstructive symptoms, such as dysphagia. Rarely, patients present with acute symptoms of hernia incarceration, such as severe epigastric pain and retching....
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2009.08.006
更新日期:2009-11-01 00:00:00
abstract::This article summarizes the pertinent points of tracheal and bronchial anatomy, including the relationships to surrounding structures. Tracheal and bronchial anatomy is essential knowledge for the thoracic surgeon, and an understanding of the anatomic relationships surrounding the airway is crucial to the safe perform...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2006.12.006
更新日期:2007-11-01 00:00:00
abstract::Despite a prospective randomized trial that reported decreased locoregional recurrence for the intentional use of sublobar resection for stage IA non-small cell lung cancer, it continues to be a point of considerable debate. Improved imaging techniques have introduced a large group of smaller and more indolent tumors ...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2016.04.007
更新日期:2016-08-01 00:00:00
abstract::This article has reviewed radiation treatment of thoracic malignancies in elderly patients. In general the literature suggests that thoracic irradiation is equally efficacious in elderly patients as in younger patients and is associated with increased but acceptable toxicity. Technical advances are allowing a further ...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2009.06.003
更新日期:2009-08-01 00:00:00
abstract::Tracheobronchomalacia is an uncommon acquired disorder of the central airways. Common symptoms include dyspnea, constant coughing, inability to raise secretions, and recurrent respiratory infections. Evaluation includes an inspiratory-expiratory chest CT (dynamic CT), an awake functional bronchoscopy, and pulmonary fu...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2018.01.006
更新日期:2018-05-01 00:00:00
abstract::Air leakage after pulmonary resections is considered the most prevalent postoperative problem, and it is often the only morbidity identified. Ideally, treatment begins with prevention; the onset of this complication should be anticipated and recognized during surgery, and intraoperative strategies should be attempted ...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2010.03.004
更新日期:2010-08-01 00:00:00
abstract::Recurrent symptomatic paraesophageal hernias (PEHs) can lead to significant morbidity if untreated. Surgical treatment of recurrent PEH can pose a great challenge. Several different surgical options are available and need to be considered on an individual basis. Before embarking on the repair of a recurrent hernia, a ...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2019.07.011
更新日期:2019-11-01 00:00:00
abstract::Development of postpneumonectomy empyema with bronchopleural fistula is a life-threatening condition that requires prompt action. Although measures should be taken to prevent bronchopleural fistula at time of pneumonectomy, many patients experience this complication. Management focuses on drainage of the pleural space...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2018.05.008
更新日期:2018-08-01 00:00:00
abstract::The advent of immune checkpoint blockade has revolutionized the management of advanced non-small cell lung cancer (NSCLC). Impressive results in the metastatic setting have prompted substantial interest in the application of these agents in earlier-stage disease. Applications of checkpoint blockade in the adjuvant set...
journal_title:Thoracic surgery clinics
pub_type: 杂志文章,评审
doi:10.1016/j.thorsurg.2020.01.001
更新日期:2020-05-01 00:00:00