Abstract:
OBJECTIVE:The purpose of this prospective study was to measure in vivo blood oxygen saturation (%O2) by MRI in children with congenital heart disease (CHD) using population-based values for T2O (T2 signal decay of fully oxygenated blood) and K (a parameter representing the deoxyhemoglobin effect) and compare the %O2 with direct cardiac catheterization measurements. BACKGROUND:MRI can determine %O2 using in vivo measurement of signal decay (T2) and an in vitro calibration curve relating T2 and %O2, based on the equation: 1/T2 = 1/T2O + K(1-%O2/100)2. Recent studies have correlated the T2/%O2 in children with CHD with the adult calibration statistics. METHODS:A total of ten children (five male, five female) with single ventricle CHD (median age 4.8 months, range 2 months to 4.4 years) undergoing cardiac catheterization were included in the study. The blood T2 measurements for each patient were performed in a 1.5 T GE CV scanner. The %O2 was then calculated based on the equation using values of T2O determined from individual hematocrits, and a population average value of K derived for children. The %O2 values were compared with direct %O2 measurements from cardiac catheterization. RESULTS:The %O2 values by MRI were strongly correlated with direct cardiac catheterization measurements (R = 0.825; P < 0.001). CONCLUSION:The study indicates that the noninvasive measurement of %O2 by MRI can accurately measure oxygen saturation in children with complex CHD.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Nield LE,Qi XL,Valsangiacomo ER,Macgowan CK,Wright GA,Hornberger LK,Yoo SJdoi
10.1007/s00247-004-1305-6keywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
179-85issue
2eissn
0301-0449issn
1432-1998journal_volume
35pub_type
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