Prolongation of levodopa responses by glycineB antagonists in parkinsonian primates.

Abstract:

:To examine the antiparkinsonian effects of blocking glycineB receptors, we designed a pilot study testing the potent and selective antagonist, PAMQX, in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. PAMQX had no intrinsic effects but markedly potentiated the antiparkinsonian action of levodopa. In a dose-dependent fashion, coadministration of the glycineB antagonist with levodopa extended the response duration by nearly 60%. It is noteworthy that PAMQX, within a considerable dose range, did not cause ataxia or other side effects. These data indicate that blocking N-methyl-D-aspartate receptors selectively to manipulate dopaminergic-mediated motor responses may be produced effectively by glycineB antagonists.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Papa SM,Auberson YP,Greenamyre JT

doi

10.1002/ana.20279

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

723-7

issue

5

eissn

0364-5134

issn

1531-8249

journal_volume

56

pub_type

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