Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.

Abstract:

:Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca(2+) stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca(2+) stores and phosphorylation of eIF2alpha.

journal_name

J Med Chem

authors

Natarajan A,Guo Y,Harbinski F,Fan YH,Chen H,Luus L,Diercks J,Aktas H,Chorev M,Halperin JA

doi

10.1021/jm0496234

keywords:

subject

Has Abstract

pub_date

2004-10-07 00:00:00

pages

4979-82

issue

21

eissn

0022-2623

issn

1520-4804

journal_volume

47

pub_type

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