Abstract:
:Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca(2+) stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca(2+) stores and phosphorylation of eIF2alpha.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Natarajan A,Guo Y,Harbinski F,Fan YH,Chen H,Luus L,Diercks J,Aktas H,Chorev M,Halperin JAdoi
10.1021/jm0496234keywords:
subject
Has Abstractpub_date
2004-10-07 00:00:00pages
4979-82issue
21eissn
0022-2623issn
1520-4804journal_volume
47pub_type
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