Sequence periodicity of Escherichia coli is concentrated in intergenic regions.

Abstract:

BACKGROUND:Sequence periodicity with a period close to the DNA helical repeat is a very basic genomic property. This genomic feature was demonstrated for many prokaryotic genomes. The Escherichia coli sequences display the period close to 11 base pairs. RESULTS:Here we demonstrate that practically only ApA/TpT dinucleotides contribute to overall dinucleotide periodicity in Escherichia coli. The noncoding sequences reveal this periodicity much more prominently compared to protein-coding sequences. The sequence periodicity of ApC/GpT, ApT and GpC dinucleotides along the Escherichia coli K-12 is found to be located as well mainly within the intergenic regions. CONCLUSIONS:The observed concentration of the dinucleotide sequence periodicity in the intergenic regions of E. coli suggests that the periodicity is a typical property of prokaryotic intergenic regions. We suppose that this preferential distribution of dinucleotide periodicity serves many biological functions; first of all, the regulation of transcription.

journal_name

BMC Mol Biol

journal_title

BMC molecular biology

authors

Hosid S,Trifonov EN,Bolshoy A

doi

10.1186/1471-2199-5-14

keywords:

subject

Has Abstract

pub_date

2004-08-26 00:00:00

pages

14

issn

1471-2199

pii

1471-2199-5-14

journal_volume

5

pub_type

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