Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1.

abstract：:The human aspects of conservation are often overlooked but will be critical for identifying strategies for biological conservation in the face of climate change. We surveyed the behavioral intentions of coastal landowners with respect to various conservation strategies aimed at facilitating ecosystem migration for tid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Field CR,Dayer AA,Elphick CS

更新日期：2017-08-22 00:00:00

abstract：:A new class of Escherichia coli mutants, referred to as grn, has been isolated by localized mutagenesis. These mutations affect the sigma subunit of DNA-dependent RNA polymerase (ribonucleoside 5'-triphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) by abolishing the expression of the lambda N gene, and they are close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,Kurihara T,Saito H,Uchida H

更新日期：1979-09-01 00:00:00

abstract：:Indirect reciprocity is a mechanism for cooperation based on shared moral systems and individual reputations. It assumes that members of a community routinely observe and assess each other and that they use this information to decide who is good or bad, and who deserves cooperation. When information is transmitted pub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Schmid L,Tkadlec J,Chatterjee K,Nowak MA

更新日期：2018-11-27 00:00:00

abstract：:Proteolipid protein (PLP) is the major myelin membrane protein of the central nervous system. We have isolated a copy of an alternatively spliced PLP gene transcript from a mouse brain cDNA library that was screened for PLP-related sequences. The encoded 241-amino acid protein differs from PLP by an internal deletion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nave KA,Lai C,Bloom FE,Milner RJ

更新日期：1987-08-01 00:00:00

abstract：:An explosion of new information linking activation of cell surface signal initiators to changes in gene expression has recently emerged. The focus of much of this information has centered around the agonist-dependent activation of the mitogen-activated protein (MAP) kinases. Although this intracellular signal transduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blenis J

更新日期：1993-07-01 00:00:00

abstract：:The BvgAS phosphorelay regulates ∼10% of the annotated genomes of Bordetella pertussis and Bordetella bronchiseptica and controls their infectious cycles. The hierarchical organization of the regulatory network allows the integration of contextual signals to control all or specific subsets of BvgAS-regulated genes. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahuja U,Shokeen B,Cheng N,Cho Y,Blum C,Coppola G,Miller JF

更新日期：2016-03-01 00:00:00

abstract：:A transcription factor required for synthesis of accurately initiated run-off transcripts by RNA polymerase II has been purified and shown to have an associated DNA-dependent ATPase (dATPase) activity that is strongly stimulated by the TATA region of promoters. This transcription factor, designated delta, was purified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conaway RC,Conaway JW

更新日期：1989-10-01 00:00:00

abstract：:Changes in external light patterns can alter cell activities in peripheral tissues through slow entrainment of the central clock in suprachiasmatic nucleus (SCN). It remains unclear whether cells in otherwise photo-insensitive tissues can achieve rapid responses to changes in external light. Here we show that light st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan SM,Chang YT,Chen CL,Wang WH,Pan MK,Chen WP,Huang WY,Xu Z,Huang HE,Chen T,Plikus MV,Chen SK,Lin SJ

更新日期：2018-07-17 00:00:00

abstract：:A single dose of N-methyl-N-nitrosourea given to sexually immature female Buf/N rats produces a high incidence of mammary adenocarcinomas. A large percentage of these tumors contain the Ha-ras oncogene, activated by a G----A transition at the second nucleotide of codon 12. Copenhagen rats, on the other hand, are compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu SJ,Archer MC

更新日期：1992-02-01 00:00:00

abstract：:During transcription, RNA polymerase II (RNAPII) must select the correct nucleotide, catalyze its addition to the growing RNA transcript, and move stepwise along the DNA until a gene is fully transcribed. In all kingdoms of life, transcription must be finely tuned to ensure an appropriate balance between fidelity and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larson MH,Zhou J,Kaplan CD,Palangat M,Kornberg RD,Landick R,Block SM

更新日期：2012-04-24 00:00:00

abstract：:Tumor metastasis is the cause of most cancer deaths. Although metastases can form in multiple end organs, the liver is recognized as a highly permissive organ. Nevertheless, there is evidence for immune cell-mediated mechanisms that function to suppress liver metastasis by certain tumors, although the underlying mecha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura Y,Inoue A,Hangai S,Saijo S,Negishi H,Nishio J,Yamasaki S,Iwakura Y,Yanai H,Taniguchi T

更新日期：2016-12-06 00:00:00

abstract：:Forkhead box P3 (FOXP3)-positive Treg cells are crucial for maintaining immune homeostasis. FOXP3 cooperates with its binding partners to elicit Treg cells' signature and function, but the molecular mechanisms underlying the modulation of the FOXP3 complex remain unclear. Here we report that Deleted in breast cancer 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao Y,Tang J,Chen W,Li Q,Nie J,Lin F,Wu Q,Chen Z,Gao Z,Fan H,Tsun A,Shen J,Chen G,Liu Z,Lou Z,Olsen NJ,Zheng SG,Li B

更新日期：2015-06-23 00:00:00

abstract：:T cells are essential for immune defenses against pathogens, such that viability of naïve T cells before antigen encounter is critical to preserve a polyclonal repertoire and prevent immunodeficiencies. The viability of naïve T cells before antigen recognition is ensured by IL-7, which drives expression of the prosurv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller ML,Mashayekhi M,Chen L,Zhou P,Liu X,Michelotti M,Tramontini Gunn N,Powers S,Zhu X,Evaristo C,Alegre ML,Molinero LL

更新日期：2014-05-20 00:00:00

abstract：:Polyadenylylated RNA synthesized after heat shock was isolated from polysomes of cultured cells of Drosophila melanogaster and used as template to prepare cDNA. An excess of poly(A)-RNA from heat-shocked cells hybridized to 80% of the cDNA, whereas cytoplasmic poly(A)-RNA from cells grown at 25 degrees could drive onl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biessmann H,Levy B,McCarthy BJ

更新日期：1978-02-01 00:00:00

abstract：:Wildfire can influence climate directly and indirectly, but little is known about the relationships between wildfire and climate during the Quaternary, especially how wildfire patterns varied over glacial-interglacial cycles. Here, we present a high-resolution soot record from the Chinese Loess Plateau; this is a reco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han Y,An Z,Marlon JR,Bradley RS,Zhan C,Arimoto R,Sun Y,Zhou W,Wu F,Wang Q,Burr GS,Cao J

更新日期：2020-03-10 00:00:00

abstract：:Our previous work [Levinger, L. & Varshavsky, A. (1982) Cell 28, 375-385] has shown that D1, a 50-kilodalton chromosomal protein of Drosophila melanogaster, is specifically associated with isolated nucleosomes that contain a complex A + T-rich satellite DNA with buoyant density of 1.688 g/ml. We show here that D1 is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinger L,Varshavsky A

更新日期：1982-12-01 00:00:00

abstract：:We previously purified a 48-kDa protein (p48) that specifically reacts with an antiserum directed against the 12 carboxyl-terminal amino acids of the c-myc gene product. Using an antiserum directed against the purified p48, we have cloned a cDNA from a human expression library. This cDNA hybrid-selects an mRNA that tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giallongo A,Feo S,Moore R,Croce CM,Showe LC

更新日期：1986-09-01 00:00:00

abstract：:Bovine pyruvate dehydrogenase phosphatase (PDP) is a Mg2+-dependent and Ca2+-stimulated heterodimer that is a member of the protein phosphatase 2C family and is localized to mitochondria. Insight into the function of the regulatory subunit of PDP (PDPr) has been gained. It decreases the sensitivity of the catalytic su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan J,Lawson JE,Reed LJ

更新日期：1996-05-14 00:00:00

abstract：:The human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR) sequences were inserted into adenovirus in place of the E1 region. The HIV-1 LTR contained in this recombinant adenovirus responds to trans-activation by tatIII in a HeLa cell line constitutively expressing that HIV-1 gene product. In addition, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice AP,Mathews MB

更新日期：1988-06-01 00:00:00

abstract：:In mitosis, chromosome, cytoskeleton, and organelle dynamics must be coordinated for successful cell division. Here, we present evidence for a role for Arf1, a small GTPase associated with the Golgi apparatus, in the orchestration of mitotic Golgi breakdown, chromosome segregation, and cytokinesis. We show that early ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altan-Bonnet N,Phair RD,Polishchuk RS,Weigert R,Lippincott-Schwartz J

更新日期：2003-11-11 00:00:00

abstract：:The skeletal muscle sarcoplasmic reticulum (SR) was investigated for the presence of well-known endoplasmic reticulum (ER) markers: the lumenal protein BiP and a group of membrane proteins recognized by an antibody raised against ER membrane vesicles. Western blots of SR fractions revealed the presence of BiP in fast-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volpe P,Villa A,Podini P,Martini A,Nori A,Panzeri MC,Meldolesi J

更新日期：1992-07-01 00:00:00

abstract：:Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs' biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with a monoclonal Ab (DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrelli A,Circosta P,Granziero L,Mazzone M,Pisacane A,Fenoglio S,Comoglio PM,Giordano S

更新日期：2006-03-28 00:00:00

abstract：:The ability of long-term cultured and monoclonal T cell populations to provide antigen-specific help was assessed in a system of Ir gene-controlled in vitro antibody responses to soluble antigens. T-cell colonies and monoclonal T-cell lines were generated which proliferated specifically in response to poly(LTyr,Glu)-p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hodes RJ,Kimoto M,Hathcock KS,Fathman CG,Singer A

更新日期：1981-10-01 00:00:00

abstract：:We have examined components of the preintegration complex of human immunodeficiency virus type 1 (HIV-1) and have analyzed features which govern the association of these components. HIV-1 nucleoprotein complexes, isolated from nuclear and cytoplasmic extracts of CD4+ cells after acute virus infection, contained viral ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bukrinsky MI,Sharova N,McDonald TL,Pushkarskaya T,Tarpley WG,Stevenson M

更新日期：1993-07-01 00:00:00

abstract：:One way to dissect the antibody response to an invading microorganism is to clone the antibody repertoire from immune donors and subsequently characterize the specific antibodies. Recently, methodological advances have allowed investigations of neutralizing antibodies against hepatitis C virus (HCV) in vitro. We have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johansson DX,Voisset C,Tarr AW,Aung M,Ball JK,Dubuisson J,Persson MA

更新日期：2007-10-09 00:00:00

abstract：:Epithelial tissues mechanically deform the surrounding extracellular matrix during embryonic development, wound repair, and tumor invasion. Ex vivo measurements of such multicellular tractions within three-dimensional (3D) biomaterials could elucidate collective dissemination during disease progression and enable prec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leggett SE,Patel M,Valentin TM,Gamboa L,Khoo AS,Williams EK,Franck C,Wong IY

更新日期：2020-03-17 00:00:00

abstract：:Viral infection leads to activation of the transcription factors interferon regulatory factor-3 and NF-kappaB, which collaborate to induce type I IFNs. The RNA helicase proteins RIG-I and MDA5 were recently identified as two cytoplasmic viral RNA sensors that recognize different species of viral RNAs produced during v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diao F,Li S,Tian Y,Zhang M,Xu LG,Zhang Y,Wang RP,Chen D,Zhai Z,Zhong B,Tien P,Shu HB

更新日期：2007-07-10 00:00:00

abstract：:The dominant insulin-stimulated ribosomal protein S6 kinase activity was purified to near homogeneity from insulin-treated 32P-labeled rat H4 hepatoma cells and found to copurify with a 70-kDa 32P-labeled polypeptide. The dominant S6 kinase purified from livers of cycloheximide-treated rats is also a 70-kDa polypeptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price DJ,Gunsalus JR,Avruch J

更新日期：1990-10-01 00:00:00

abstract：:To explore the lethal, ataxic phenotype of complex I deficiency in Ndufs4 knockout (KO) mice, we inactivated Ndufs4 selectively in neurons and glia (NesKO mice). NesKO mice manifested the same symptoms as KO mice including retarded growth, loss of motor ability, breathing abnormalities, and death by approximately 7 wk...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quintana A,Kruse SE,Kapur RP,Sanz E,Palmiter RD

更新日期：2010-06-15 00:00:00

abstract：:The notion that tRNA and 5S rRNA interact through evolutionarily conserved complementary sequences has been tested by nucleolytic modification of the 5S rRNA, using the modified rRNA to reconstitute the large ribosomal subunit, and assaying for poly(uridylic acid)-directed polyphenylalanine synthesis. The 5S rRNA sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace B,Matthews EA,Johnson KD,Cantor CR,Pace NR

更新日期：1982-01-01 00:00:00