Possible causes of central pontine myelinolysis after liver transplantation.

Abstract:

AIM:To sum up the clinical characteristics of patients with central pontine myelinolysis (CPM) after orthotopic liver transplantation (OLT) and to document the possible causes of CPM. METHODS:Data of 142 patients undergoing OLT between January 1999 to May 2003 were analyzed retrospectively. Following risk factors during perioperation were analyzed in patients with and without CPM: primary liver disease, preoperative serum sodium level, magnesium level and plasma osmolality, fluctuation degree of serum sodium concentration, and immunosuppressive drug level, etc. RESULTS:A total of 13 (9.2%) neurologic symptoms appeared in 142 patients post-operation including 5 cases (3.5%) with CPM and 8 cases (5.6%) with cerebral hemorrhage or infarct. Two patients developing CPM after OLT had a hyponatremia history before operation (serum sodium<130 mmol/L), their mean serum sodium level was 130.6 +/- 5.54 mmol/L. The serum sodium level was significantly lower in CPM patients than in patients without neurologic complications or with cerebral hemorrhage/infarct (P<0.05). The increase in serum sodiumduring perioperative 48 h after OLT in patients with CPM was significantly greater than that in patients with cerebral hemorrhage/infarct but without neurologic complications (19.5 +/- 6.54 mmol/L, 10.1 +/- 6.43 mmol/L, 4.5 +/- 4.34 mmol/L, respectively, P<0.05). Plasma osmolality was greatly increased postoperation in patients with CPM. Hypomagnesemia was noted in all patients perioperation, but there were no significant differences between groups. The duration of operation on patients with CPM was longer than that on others (492 +/- 190.05 min, P<0.05). Cyclosporin A (CsA) levels were normal in all patients, but there were significant differences between patients with or without neurologic complications (P<0.05). CONCLUSION:CPM may be more prevalent following liver transplantation. Although the diagnosis of CPM after OLT can be made by overall neurologic evaluations including magnetic resonance imaging (MRI) of the head, the mortality is still very high. The occurance of CPM may be associated with such factors as hyponatremia, rapid rise of serum sodium concentration, plasma osmolality increase postoperation, the duration of operation, and high CsA levels.

journal_name

World J Gastroenterol

authors

Yu J,Zheng SS,Liang TB,Shen Y,Wang WL,Ke QH

doi

10.3748/wjg.v10.i17.2540

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

2540-3

issue

17

eissn

1007-9327

issn

2219-2840

journal_volume

10

pub_type

杂志文章
  • Sp1 contributes to overexpression of stanniocalcin 2 through regulation of promoter activity in colon adenocarcinoma.

    abstract:BACKGROUND:Aberrant expression of stanniocalcin 2 (STC2) is implicated in colon adenocarcinoma (COAD). A previous study identified that STC2 functions as a tumor promoter to drive development of some cancers, but the role of its overexpression in the development of COAD remains unclear. AIM:To evaluate the regulation ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i22.2776

    authors: Li JB,Liu ZX,Zhang R,Ma SP,Lin T,Li YX,Yang SH,Zhang WC,Wang YP

    更新日期:2019-06-14 00:00:00

  • Effects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways.

    abstract:AIM:To study the effects of IkappaBalpha and its mutants (IkappaBalphaM, IkappaBalpha243N, IkappaBalphaM244C) on NF-kappaB, p53 and their downstream target genes. The relationship of NF-kappaB, p53, and IkappaBalpha was further discussed. METHODS:pECFP-IkappaBalpha, pECFP-IkappaBalphaM (amino acides 1-317, Ser32, 36A)...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i41.6658

    authors: Li X,Xing D,Wang J,Zhu DB,Zhang L,Chen XJ,Sun FY,Hong A

    更新日期:2006-11-07 00:00:00

  • Peripheral mechanism of inhibitory effect of centrally administrated histamine on gastric acid secretion.

    abstract::AIM:To study the peripheral mechanism of the inhibitory effect of intra-third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats.METHODS:Gastric acid was continuously washed with 37&mgr; saline by a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenously (iv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v4.i3.222

    authors: Zhang ZF,Wang ZL,Lu GQ

    更新日期:1998-06-01 00:00:00

  • Efficacy, effectiveness, immunogenicity--are not the same in vaccinology.

    abstract::Manuscript of Carrera et al is devoted to immunization in inflammatory bowel disease (IBD) that is very important issue in gastroenterology. However, some specific definitions used in the article need clarification. Efficacy of vaccine is measured in a randomised, placebo-controlled studies, that are expensive and dif...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.v19.i41.7217

    authors: Banaszkiewicz A,Radzikowski A

    更新日期:2013-11-07 00:00:00

  • Induction of clinical response and remission of inflammatory bowel disease by use of herbal medicines: a meta-analysis.

    abstract:AIM:To evaluate the efficacy and tolerability of herbal medicines in inflammatory bowel disease (IBD) by conducting a meta-analysis. METHODS:Electronic databases were searched for studies investigating efficacy and/or tolerability of herbal medicines in the management of different types of IBD. The search terms were: ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v19.i34.5738

    authors: Rahimi R,Nikfar S,Abdollahi M

    更新日期:2013-09-14 00:00:00

  • Relationship between nuclear morphometry, DNA content and resectability of pancreatic cancer.

    abstract:AIM:To investigate the association of nuclear morphometry and DNA content with resectability of pancreatic cancer. METHODS:A total of 36 patients with pancreatic adenocarcinoma were divided into resectable group and unresectable group. The nuclear morphometry and DNA contents of tumor cells were analyzed by IBAS autoi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i8.1863

    authors: He YC,Peng W,Qiao JG,Cao J,Chen JW

    更新日期:2003-08-01 00:00:00

  • Estrogens and the pathophysiology of the biliary tree.

    abstract::The scientific framework concerning estrogen effects on different tissues has expanded enormously during the last decades, when estrogen receptor (ER) subtypes were identified. Estrogens are not only essential for the female reproductive system, but they also control fundamental functions in other tissues including th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i22.3537

    authors: Alvaro D,Mancino MG,Onori P,Franchitto A,Alpini G,Francis H,Glaser S,Gaudio E

    更新日期:2006-06-14 00:00:00

  • DNA ploidy analysis and expression of MMP-9, TIMP-2, and E-cadherin in gastric carcinoma.

    abstract:AIM:To investigate DNA ploidy and expression of MMP-9, TIMP-2, and E-cadherin in gastric carcinoma and to explore the mechanism of invasion and metastasis of gastric carcinoma. METHODS:Immunohistochemical methods were used to detect the expressions of MMP-9, TIMP-2, and E-cadherin in 156 cases, including 99 cases of g...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i36.5592

    authors: Zhang JF,Zhang YP,Hao FY,Zhang CX,Li YJ,Ji XR

    更新日期:2005-09-28 00:00:00

  • A pilot study of single-use endoscopy in screening acute gastrointestinal bleeding.

    abstract:AIM:To investigate the feasibility of a single-use endoscopy as an alternative procedure to nasogastric lavage in patients with acute gastrointestinal (GI) bleeding. METHODS:Patients who presented with hematemesis, melena or hematochezia were enrolled in this study. EG scan™ and conventional esophagogastroduodenoscopy...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i1.103

    authors: Cho JH,Kim HM,Lee S,Kim YJ,Han KJ,Cho HG,Song SY

    更新日期:2013-01-07 00:00:00

  • Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis.

    abstract::Nestin is a class VI intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in normal tissues. Under pathological con...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i4.409

    authors: Ishiwata T,Matsuda Y,Naito Z

    更新日期:2011-01-28 00:00:00

  • Hepatocellular carcinoma occurring in a Crohn's disease patient.

    abstract::We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients. A 37-year-old Japanese man with an 8-year history of CD and a medication history of azathioprine underwent...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i25.3215

    authors: Ishida M,Naka S,Shiomi H,Tsujikawa T,Andoh A,Nakahara T,Saito Y,Kurumi Y,Takikita-Suzuki M,Kojima F,Hotta M,Tani T,Fujiyama Y,Okabe H

    更新日期:2010-07-07 00:00:00

  • Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model.

    abstract:AIM:To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate. METHODS:Dexamethasone cholesteryl butyrate-solid lipid nanoparticles (DxCb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanofor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i23.4200

    authors: Dianzani C,Foglietta F,Ferrara B,Rosa AC,Muntoni E,Gasco P,Della Pepa C,Canaparo R,Serpe L

    更新日期:2017-06-21 00:00:00

  • Stable expression of human cytochrome P450 2D6*10 in HepG2 cells.

    abstract:AIM:Over 90% of drugs are metabolized by the cytochrome P-450 (CYP) family of liver isoenzymes. The most important enzymes are CYP1A2, 3A4, 2C9/19, 2D6 and 2E1. Although CYP2D6 accounts for <2% of the total CYP liver enzyme content, it mediates metabolism in almost 25% of drugs. In order to study its enzymatic activity...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i2.234

    authors: Zhuge J,Yu YN,Wu XD

    更新日期:2004-01-15 00:00:00

  • Mechanism of diarrhea in microscopic colitis.

    abstract:AIM:To search the pathophysiological mechanism of diarrhea based on daily stool weights, fecal electrolytes, osmotic gap and pH. METHODS:Seventy-six patients were included: 51 with microscopic colitis (MC) (40 with lymphocytic colitis (LC); 11 with collagenous colitis (CC)); 7 with MC without diarrhea and 18 as a cont...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i35.5535

    authors: Protic M,Jojic N,Bojic D,Milutinovic S,Necic D,Bojic B,Svorcan P,Krstic M,Popovic O

    更新日期:2005-09-21 00:00:00

  • Screening for pancreatic cancer in familial high-risk individuals: A systematic review.

    abstract:AIM:To analyze the benefits and harms of pancreatic cancer screening in familial high-risk individuals (HRIs). METHODS:Studies were identified by searching PubMed, EBSCO, ClinicalTrials.gov and the Cochrane database from database inception to June 2014. We also obtained papers from the reference lists of pertinent stu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i28.8678

    authors: Lu C,Xu CF,Wan XY,Zhu HT,Yu CH,Li YM

    更新日期:2015-07-28 00:00:00

  • How much helpful is the capsule endoscopy for the diagnosis of small bowel lesions?

    abstract:AIM:To assess the practically usefulness and diagnostic yield of this new method in a group of patients with suspected small bowel lesions. METHODS:Capsule endoscopic (CE) examination by using M2A capsule endoscope TM (Given Imaging, Yoqneam, Israel) was performed in thirty nine patients (26 males, 13 females) with su...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v12.i24.3906

    authors: Ersoy O,Sivri B,Arslan S,Batman F,Bayraktar Y

    更新日期:2006-06-28 00:00:00

  • Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis.

    abstract:AIM:To investigate the association between thrombocytopenia and relapse after treatment for hepatocellular carcinoma (HCC). METHODS:We searched the PubMed, EMBASE, and Web of Science databases to obtain eligible studies. The hazard ratios (HRs) values and 95% confidence intervals (CIs) were pooled by random effects mo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v21.i25.7895

    authors: Pang Q,Qu K,Bi JB,Liu SS,Zhang JY,Song SD,Lin T,Xu XS,Wan Y,Tai MH,Liu HC,Dong YF,Liu C

    更新日期:2015-07-07 00:00:00

  • Diagnostic utility of IgG and IgM immunohistochemistry in autoimmune liver disease.

    abstract:AIM:To assess the role of IgM and IgG immunohistochemistry (IHC) in the evaluation of autoimmune liver conditions--autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). METHODS:Forty one biopsies from untreated patients diagnosed with autoimmune liver disease (AIH, n = ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i4.453

    authors: Moreira RK,Revetta F,Koehler E,Washington MK

    更新日期:2010-01-28 00:00:00

  • Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication.

    abstract:AIM:To study the blood-brain barrier integrity, brain edema, animal behavior and ammonia plasma levels in prehepatic portal hypertensive rats with and without acute liver intoxication. METHODS:Adults male Wistar rats were divided into four groups. Group I: sham operation; II: Prehepatic portal hypertension, produced b...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i9.1321

    authors: Scorticati C,Prestifilippo JP,Eizayaga FX,Castro JL,Romay S,Fernández MA,Lemberg A,Perazzo JC

    更新日期:2004-05-01 00:00:00

  • Organoids of liver diseases: From bench to bedside.

    abstract::Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological spec...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i16.1913

    authors: Wu LJ,Chen ZY,Wang Y,Zhao JG,Xie XZ,Chen G

    更新日期:2019-04-28 00:00:00

  • Cerebral lipiodol embolism following transcatheter arterial chemoembolization for hepatocellular carcinoma.

    abstract::Cerebral lipiodol embolism (CLE) is an extremely rare complication of transcatheter arterial chemoembolization for hepatocellular carcinoma (HCC). The authors present a case of CLE that occurred after the second hepatic arterial chemoembolization for HCC, and attempt to introduce several plausible mechanisms of CLE, a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v16.i3.398

    authors: Wu L,Yang YF,Liang J,Shen SQ,Ge NJ,Wu MC

    更新日期:2010-01-21 00:00:00

  • Fenofibrate for patients with asymptomatic primary biliary cirrhosis.

    abstract:AIM:Primary biliary cirrhosis (PBC) is a chronic, cholestatic disease of autoimmune etiology, the histology of which shows a destruction of the intrahepatic bile duct and portal inflammation. Ursodeoxycholic acid (UDCA) is now used as a first-line drug for asymptomatic PBC (aPBC) because it is reported that UDCA decrea...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v10.i6.894

    authors: Dohmen K,Mizuta T,Nakamuta M,Shimohashi N,Ishibashi H,Yamamoto K

    更新日期:2004-03-15 00:00:00

  • Effects of early enteral nutrition on immune function of severe acute pancreatitis patients.

    abstract:AIM:To investigate the effects of early enteral nutrition (EEN) on the immune function and clinical outcome of patients with severe acute pancreatitis (SAP). METHODS:Patients were randomly allocated to receive EEN or delayed enteral nutrition (DEN). Enteral nutrition was started within 48 h after admission in EEN grou...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v19.i6.917

    authors: Sun JK,Mu XW,Li WQ,Tong ZH,Li J,Zheng SY

    更新日期:2013-02-14 00:00:00

  • Improvement of type 2 diabetes mellitus after gastric cancer surgery: short-term outcome analysis after gastrectomy.

    abstract:AIM:To evaluate the effect of gastrectomy on diabetes control in patients with type 2 diabetes mellitus and early gastric cancer. METHODS:Data from 64 patients with early gastric cancer and type 2 diabetes mellitus were prospectively collected. All patients underwent curative gastrectomy (36 subtotal gastrectomy with ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i48.9410

    authors: An JY,Kim YM,Yun MA,Jeon BH,Noh SH

    更新日期:2013-12-28 00:00:00

  • Noninvasive assessment of alcoholic liver disease using unidimensional transient elastography (Fibroscan(®)).

    abstract::Unidimensional transient elastography (TE) is a noninvasive technique, which has been increasingly used in the assessment of diffuse liver diseases. This paper focuses on reviewing the existing data on the use of TE in the diagnosis of fibrosis and in monitoring disease progression in alcoholic liver disease, on the f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i42.11914

    authors: Lupsor-Platon M,Badea R

    更新日期:2015-11-14 00:00:00

  • High concentration of antimitochondrial antibodies predicts progressive primary biliary cirrhosis.

    abstract:AIM:To evaluate the serum concentration of antimitochondrial antibodies (AMAs) as a prognostic indicator of progressive primary biliary cirrhosis (pPBC). METHODS:Serum concentrations of AMA subtypes (anti-M2, anti-M4, and anti-M9), biochemical indices of liver function and Mayo risk factor (MRF) were determined in 30 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i36.5706

    authors: Flisiak R,Pelszynska M,Prokopowicz D,Rogalska M,Grygoruk U

    更新日期:2005-09-28 00:00:00

  • Prominent role of gamma-glutamyl-transpeptidase on the growth of Helicobacter pylori.

    abstract:AIM:gamma-glutamyl transpeptidase (GGT) has been reported as a virulence and colonizing factor of Helicobacter pylori (H pylori). This study examined the effect of GGT on the growth of H pylori. METHODS:Standard H pylori strain NCTC 11637 and 4 clinical isolates with different levels of GGT activity as measured by an ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i20.2994

    authors: Gong M,Ho B

    更新日期:2004-10-15 00:00:00

  • Application of contrast-enhanced intraoperative ultrasonography in the decision-making about hepatocellular carcinoma operation.

    abstract:AIM:To evaluate the detection and differentiation ability of contrast-enhanced intraoperative ultrasonography (CE-IOUS) in hepatocellular carcinoma (HCC) operations. METHODS:Clinical data of 50 HCC patients were retrospective analyzed. The sensitivity, specificity, false negative and false positive rates of contrast e...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i4.508

    authors: Wu H,Lu Q,Luo Y,He XL,Zeng Y

    更新日期:2010-01-28 00:00:00

  • Diagnosis and treatment of benign multicystic peritoneal mesothelioma.

    abstract::Benign multicystic peritoneal mesothelioma (BMPM) is a rare cystic mesothelial lesion that occurs predominantly in reproductive aged women. A 56-year-old Caucasian male was admitted to our surgical department with a chief complaint of a painful mass in his right lower abdomen for almost 2 years. The physical examinati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i39.6689

    authors: Wang TB,Dai WG,Liu DW,Shi HP,Dong WG

    更新日期:2013-10-21 00:00:00

  • Size does not determine the grade of malignancy of early invasive colorectal cancer.

    abstract:AIM:To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers (EI-CRCs), and to determine whether malignancy grade depends on size. METHODS:A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.2708

    authors: Matsuda T,Saito Y,Fujii T,Uraoka T,Nakajima T,Kobayashi N,Emura F,Ono A,Shimoda T,Ikematsu H,Fu KI,Sano Y,Fujimori T

    更新日期:2009-06-14 00:00:00