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Extracellular regulation of TGF-beta activity in wound repair: growth factor latency as a sensor mechanism for injury.

Abstract：

:The transforming growth factor-beta (TGFbeta) family of growth factors are major regulators of wound repair, scar formation, and fibrosis. One of the prominent features of TGFbeta biology is the fact that this growth factor is secreted as a latent precursor, which may be directed to and stored at specific sites in the cellular microenvironment. Targeting and mobilization, and particularly extracellular activation of latent TGF-beta control the biological action of this growth factor. This review will focus on mechanisms of extracellular TGF-beta regulation relevant to and potentially operating in wound repair and scarring.

journal_name

Thromb Haemost

journal_title

Thrombosis and haemostasis

authors

Brunner G,Blakytny R

doi

10.1160/TH04-05-0324

keywords:

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

253-61

issue

2

eissn

0340-6245

issn

2567-689X

pii

04080253

journal_volume

92

pub_type

杂志文章,评审

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