Abstract:
:Replication of HIV-1 and N-tropic murine leukemia virus (N-MLV) is restricted in a number of different primate cells. In some cell lines, cross-saturation experiments suggest that the two viruses are interacting with the same restriction factor. Recently, Trim5alpha protein from rhesus monkey was found to restrict HIV-1. We have confirmed this result and have shown that Trim5alpha from two African green monkey cell lines, Vero and CV-1, also restricts HIV-1. In addition, we show that human, rhesus, and African green monkey Trim5alpha can restrict N-MLV. By using a panel of MLV capsid mutants, subtle differences in the anti-MLV activity were identified among the different primate Trim5alpha cDNAs. Trim1 isolated from humans and green monkeys was also found to restrict N-MLV. We hypothesize that the Trim family of proteins plays a widespread role in innate immunity to viral infection.
journal_name
Proc Natl Acad Sci U S Aauthors
Yap MW,Nisole S,Lynch C,Stoye JPdoi
10.1073/pnas.0402876101keywords:
subject
Has Abstractpub_date
2004-07-20 00:00:00pages
10786-91issue
29eissn
0027-8424issn
1091-6490pii
0402876101journal_volume
101pub_type
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