Abstract:
STUDY DESIGN:Posterolateral lumbar fusions were performed in nicotine-exposed, New Zealand white rabbits. Animals that developed a pseudarthrosis were then regrafted with no graft, autograft, or osteogenic protein-1 (OP-1). OBJECTIVES:To establish a model of pseudarthrosis repair and to evaluate the ability of OP-1 to induce fusion in this model. SUMMARY OF BACKGROUND DATA:OP-1 has been shown to have a 100% fusion rate in an established rabbit fusion model, even in the presence of nicotine, which is known to inhibit fusion. METHODS:Forty-four New Zealand white rabbits underwent posterolateral lumbar fusion with iliac crest autograft. To maximize the incidence of pseudarthroses, nicotine was administered to all rabbits. At 5 weeks, the spines were explored, and all pseudarthroses were redecorticated and grafted with no graft, autograft, or OP-1. At 10 weeks, the rabbits were killed and fusions masses were assessed with manual palpation, radiography, computed tomography, and/or histology. RESULTS:Nine rabbits (20%) were lost to complications. Thirty-four (94%) had pseudarthroses on exploration at 5 weeks. By manual palpation at 10 weeks, 1 of 10 (10%) pseudarthroses that received no graft fused, 5 of 12 (42%) pseudarthroses that received autograft fused, and 9 of 11 (82%) pseudarthroses that received OP-1 fused. Computed tomography and histology further characterized the fusion masses. CONCLUSIONS:This study establishes a model for treatment of pseudarthroses. OP-1, which has previously been shown to have 100% fusion rate in animal models, outperformed autograft and induced fusion in 82% of rabbits.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Grauer JN,Vaccaro AR,Kato M,Kwon BK,Beiner JM,Patel TC,Hilibrand AS,Chiba K,Albert TJdoi
10.1097/01.brs.0000129028.25671.96keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1405-12issue
13eissn
0362-2436issn
1528-1159pii
00007632-200407010-00006journal_volume
29pub_type
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