Abstract:
:The presence of professional antigen-presenting cells in tumours can influence their further spreading. Location of cells exhibiting a specific marker of Langerhans cells--Langerin, and the 175 kD mannose receptor as a marker of dendritic cells of non-Langerhans type and macrophages, was studied using double staining in the normal human epidermis and in basal cell carcinomas. The Langerin-positive cells strictly colonized the epidermis and no cells were found in the dermis, where 175 kD mannose receptor-exhibiting cells were present. Very rare elements in the epidermal/dermal interface were positive for both markers. A low incidence of Langerin-positive cells was found in tumours and 1/3 of studied carcinomas were even Langerhans cell-free. The extraepithelial presence of Langerin-positive cells forming contacts with dendrite-like protrusions of 175 kD mannose receptor-exhibiting cells was found in connective tissue surrounding the tumour epithelium and indicates possible cooperation of both elements.
journal_name
Folia Biol (Praha)journal_title
Folia biologicaauthors
Plzáková Z,Chovanec M,Smetana K Jr,Plzák J,Stork J,Saeland Skeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
71-3issue
2eissn
0015-5500pii
FB2004A0012journal_volume
50pub_type
杂志文章相关文献
FOLIA BIOLOGICA文献大全