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Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations.

Abstract：

OBJECTIVE:To investigate the impact of body weight (BW) and insulin levels on gonadotropin and androgen levels in women with the polycystic ovarian syndrome (PCOS). DESIGN:Comparative study of endocrinologic parameters in PCOS women. SETTING:University Hospital Reproductive Endocrinology Unit. PATIENTS:Thirty obese and 19 nonobese women with PCOS. Seven obese and 7 nonobese normal women. MAIN OUTCOME MEASURES:Serum concentrations of insulin, testosterone, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone. Serum LH response to gonadotropin-releasing hormone (GnRH) administration and assessment of insulin resistance by the continuous infusion of glucose with model assessment (CIGMA) test. RESULTS:Fasting insulin levels correlated with body mass index (BMI). Basal LH levels correlated inversely with BMI. Nonobese women with PCOS had a higher LH response to GnRH than obese women with PCOS. Only obese women with PCOS showed insulin resistance and fasting hyperinsulinemia. CONCLUSIONS:The data suggest that women with PCOS may be divided into two subgroups: those with obesity, insulin resistance, hyperinsulinemia, and normal/minimally elevated LH levels and those with normal BW, elevated LH levels, and normoinsulinemia.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Dale PO,Tanbo T,Vaaler S,Abyholm T

doi

10.1016/s0015-0282(16)55249-2

keywords:

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

487-91

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)55249-2

journal_volume

58

pub_type

杂志文章

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