Abstract：
:Mycobacterium bovis BCG vaccine significantly reduces the risk of tuberculosis by 50% and continues to be used to prevent tuberculosis around the world. However, it has been shown to be ineffective in some geographical regions. The existence of different BCG strains was described more than 60 years ago, these vary in their antigenic content but the genetic mutations in BCG strains have yet been shown to affect their protection. After the declaration of tuberculosis as a global emergency in 1993, current research attempts to develop a novel more-effective vaccine. Using new technologies, recombinant, auxotroph, DNA, subunit and phylogenetically closely related mycobacteria, naturally or genetically attenuated, have been used as vaccines in animal models, but their protective efficacy, is less than that offered by the current BCG vaccine. Today it is mandatory that a major effort be made to understand how different BCG vaccine strains influence immune response and why in some cases vaccines have failed, so we can rationally develop the next generation of tuberculosis vaccines to reduce the prevalence from 10% to less than 2 % for developed countries.
journal_name
Ann Clin Microbiol Antimicrobjournal_title
Annals of clinical microbiology and antimicrobialsauthors
Castañón-Arreola M,López-Vidal Ydoi
10.1186/1476-0711-3-10keywords:
subject
Has Abstractpub_date
2004-06-03 00:00:00pages
10issn
1476-0711pii
1476-0711-3-10journal_volume
3pub_type
杂志文章abstract：BACKGROUND:Drug therapy is recommended in conjunction with surgery in treatment of actinomycetoma. The specific prescription depends on the type of bacteria (actinomycetoma) or fungi (eumycetoma) causing the disease and their in vitro antimicrobial susceptibility. OBJECTIVES:To investigate the antimicrobial susceptibi...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-10-24
更新日期：2011-06-06 00:00:00
abstract：BACKGROUND:Farnesol is a sesquiterpene alcohol produced by many organisms, and also found in several essential oils. Its role as a quorum sensing molecule and as a virulence factor of Candida albicans has been well described. Studies revealed that farnesol affect the growth of a number of bacteria and fungi, pointing t...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-8-13
更新日期：2009-04-29 00:00:00
abstract：:Ebola virus disease (EVD) is a potentially fatal haemorrhagic disease of humans. The last and most serious outbreak of Ebola virus (EBOV) started in December 2013 in West Africa and also affected other continents. Animals such as fruit bats and non-human primates are potential sources of EBOV. This review highlights t...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章,评审
doi：10.1186/s12941-015-0089-x
更新日期：2015-05-28 00:00:00
abstract：BACKGROUND:Tuberculous spondylitis (Pott's disease) is an ancient human disease. Because it is rare in high-income, tuberculosis (TB) low incidence countries, misdiagnoses occur as sufficient clinical experience is lacking. CASE PRESENTATION:We describe a fatal case of a patient with spinal TB, who was mistakenly irra...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-8-32
更新日期：2009-11-20 00:00:00
abstract：BACKGROUND:Drug resistance in Mycobacterium tuberculosis (MTB) is a major health issue worldwide. Recently, next-generation sequencing (NGS) technology has begun to be used to detect resistance genes of MTB. We aimed to assess the clinical usefulness of Ion S5 NGS TB research panel for detecting MTB resistance in Korea...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-018-0300-y
更新日期：2019-01-03 00:00:00
abstract：BACKGROUND:Disinfection, antisepsis and sterilization (DAS) practices are of critical importance in hospital practice. This study aims to investigate the daily DAS practices of private hospitals in Istanbul, Turkey. METHODS:The DAS practices of 155 private hospitals in Istanbul province were investigated using a quest...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-015-0073-5
更新日期：2015-03-19 00:00:00
abstract：BACKGROUND:Klebsiella pneumoniae is a frequent nosocomial pathogen, with the multidrug-resistant (MDR) K. pneumoniae being a major public health concern, frequently causing difficult-to-treat infections worldwide. The aim of this study was to investigate the molecular characterization of clinical MDR Klebsiella pneumon...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-13-16
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:A growing number of rapid Helicobacter pylori antibody tests are commercially available now, however, some of these tests are often used without sufficient evaluation. The aim of this study was to evaluate the performance of a commercially available rapid whole-blood immunoassay (gabControl(®) H. pylori; gab...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-016-0161-1
更新日期：2016-08-08 00:00:00
abstract：BACKGROUND:Cationic antimicrobial peptides (CAMPs) are well recognized to be promising as novel antimicrobial and antitumor agents. To obtain novel skeletons of CAMPs, we propose a simple strategy using acid-amide substitution (i.e. Glu→Gln, Asp→Asn) to confer net positive charge to natural non-antimicrobial sequences ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-10-11
更新日期：2011-03-22 00:00:00
abstract：BACKGROUND:Urinary tract infections (UTI) can lead to poor maternal and perinatal outcomes. Investigating epidemiology of UTI and antibiotics sensitivity among pregnant women is fundamental for care-givers and health planners. METHODS:A cross sectional study has been conducted at Khartoum north teaching hospital Anten...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-10-2
更新日期：2011-01-18 00:00:00
abstract：:Resistance to beta-lactam antibiotics in enteric Gram-negative bacilli may be difficult to detect using standard methods of either Kirby-Bauer disc diffusion (KBDD) or broth dilution for minimal inhibitory concentration (MIC). This difficulty is due to genetic differences in resistance determinants, differences in lev...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-3-13
更新日期：2004-07-15 00:00:00
abstract：:Stenotrophomonas maltophilia (S. maltophilia) has recently emerged as an important nosocomial pathogen. Treatment of invasive infections caused by this organism is difficult as the bacterium is frequently resistant to a wide range of commonly used antimicrobials. Trimethoprim-sulfamethoxazole (TMP - SXT) is recommende...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-5-23
更新日期：2006-09-18 00:00:00
abstract：INTRODUCTION:Antibiotic resistance decreases success of Helicobacter pylori (Hp) eradication. Recently published results show low rate of resistance and better compliance with moxifloxacin based regiments. AIMS&METHODS: Whether 7 days moxifloxacin with lansoprasole and amoxycillin can be compared with 10 days moxifloxa...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章,随机对照试验
doi：10.1186/1476-0711-9-13
更新日期：2010-04-15 00:00:00
abstract：BACKGROUND:Escherichia coli is the commonest cause of community and nosocomial urinary tract infection (UTI). Antibiotic treatment is usually empirical relying on susceptibility data from local surveillance studies. We therefore set out to determine levels of resistance to 8 commonly used antimicrobial agents amongst a...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-7-13
更新日期：2008-06-18 00:00:00
abstract：BACKGROUND:Aspergillus is a ubiquitous soil-dwelling fungus known to cause significant pulmonary infection in immunocompromised patients. The incidence of aspergillosis has increased during the past two decades and is a frequently lethal complication of acute leukemia patients that occurs following both chemotherapy an...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-5-17
更新日期：2006-07-27 00:00:00
abstract：BACKGROUND:Hepatotoxicity is one of the most serious complications of highly active antiretroviral therapy (HAART). The aim of this report is to analyse an HIV infected patient on HAART including nevirapine and taking antidepressive agents, with acute toxic hepatitis. CASE PRESENTATION:A 39 year old patient diagnosed ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-1-1
更新日期：2002-09-16 00:00:00
abstract：:An 87 -year-old female who was undergoing peritoneal dialysis presented with peritonitis caused by Alcaligenes faecalis and Pantoea agglomerans in consecutive years. With the following report we discuss the importance of these unusual microorganisms in peritoneal dialysis patients. ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-10-12
更新日期：2011-04-10 00:00:00
abstract：BACKGROUND:Escherichia coli isolates of equine faecal origin were investigated for antibiotic resistance, resistance genes and their ability to perform horizontal transfer. METHODS:In total, 264 faecal samples were collected from 138 horses in hospital and community livery premises in northwest England, yielding 296 r...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-9-12
更新日期：2010-04-07 00:00:00
abstract：BACKGROUND:In 2002 we investigated an outbreak comprising 231 patients in Norway, caused by Pseudomonas aeruginosa and linked to the use of contaminated mouth swabs called Dent-O-Sept. Here we describe the extent of contamination of the swabs, and identify critical points in the production process that made the contami...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-6-3
更新日期：2007-03-13 00:00:00
abstract：BACKGROUND:Clinical microbiology laboratories have to accurately identify clinical microbes. However, some isolates are difficult to identify by the automated biochemical text platforms, which are called "difficult-to-identify" microbes in this study. Therefore, the ability of 16S ribosomal DNA (16S rDNA) and internal ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-13-1
更新日期：2014-01-03 00:00:00
abstract：BACKGROUND:Raoultella planticola, a Gram-negative, aerobic bacillus commonly isolated from soil and water, rarely causes invasive infections in humans. Septic shock from R. planticola after burn injury has not been previously reported. CASE PRESENTATION:A 79-year-old male was admitted to the emergency intensive care u...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-018-0270-0
更新日期：2018-05-04 00:00:00
abstract：BACKGROUND:Training of infectious disease (ID) specialists is structured on classical clinical microbiology training in Turkey and ID specialists work as clinical microbiologists at the same time. Hence, this study aimed to determine the clinical skills and knowledge required by clinical microbiologists. METHODS:A cro...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-10-38
更新日期：2011-12-16 00:00:00
abstract：BACKGROUND:Multidrug resistant Pseudomonas aeruginosa harbours integrons and other mobile genetic elements such as plasmids and transposons, which easily disseminate antibiotic resistance genes among clinical strains of P. aeruginosa. METHODOLOGY:Plasmid extraction of 54 clinical isolates of P. aeruginosa was carried ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-12-29
更新日期：2013-10-21 00:00:00
abstract：BACKGROUND:The aim of the present work was to evaluate the antibacterial effect of 3,4-DHPEA-EA (methyl-4-(2-(3,4-dihydroxyphenethoxy)-2-oxoethyl)-3-formyl-2-methyl-3,4-dihydro-2H-pyran-5-carboxylate), a derivate of oleuropein, against a range of Gram-positive bacteria, including ATCC strains, food and clinical isolate...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-13-24
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Previous studies report high prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) colonization among imprisoned populations. However, there are no data on that prevalence in Brazilian correctional institutions. FINDINGS:We tested 302 male prisoners for nasopharyngeal colonization with Staphyloco...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-13-25
更新日期：2014-07-02 00:00:00
abstract：BACKGROUND:The consumption of carbapenems has increased worldwide, together with the increase in resistant gram negative bacilli. Subsequently, the prevalence of carbapenem-resistant Acinetobacter infections has increased rapidly and become a significant problem particularly in intensive care unit patients. The aim of ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-13-7
更新日期：2014-01-09 00:00:00
abstract：BACKGROUND:Cat-scratch disease (CSD) is a zoonotic infection caused by Bartonella henselae and B. clarridgeiae. The typical manifestations of CSD include regional lymphadenitis and fever. However, CSD can have a wide variety of clinical manifestations that can lead to incorrect diagnoses and prolonged hospital stays. ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-019-0322-0
更新日期：2019-07-15 00:00:00
abstract：BACKGROUND:Aquilaria crassna Pierre ex Lecomte has been traditionally used in Thailand for treatment of infectious diseases such as diarrhoea and skin diseases for a long time. The main objectives of this study were to examine antibacterial activity of the Aquilaria crassna leaf extract against Staphylococcus epidermid...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-12-20
更新日期：2013-08-20 00:00:00
abstract：BACKGROUND:Leishmaniasis and malaria are the two most common parasitic diseases and responsible for large number of deaths per year particularly in developing countries like Pakistan. Majority of Pakistan population rely on medicinal plants due to their low socio-economic status. The present review was designed to gath...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章,评审
doi：10.1186/s12941-016-0170-0
更新日期：2016-09-20 00:00:00
abstract：BACKGROUND:Four medicinal plants (Chrozophora hierosolymitana Spreng, Chrysanthemum leucanthemum L., Ephedra gerardiana Wall. ex Stapf, and Quercus dilatata L.) used by indigenous healers to treat various infectious diseases were selected for the present study. The major objective of the present study was isolation and...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-11-11
更新日期：2012-05-03 00:00:00
