Abstract：
:The phenotypic expression of cardiomyopathy is greatly influenced by extrinsic factors other than intrinsic genetic defects, such as environmental stress. Exercise is assumed to be an important extrinsic factor, since sudden death is sometimes seen during exercise in young patients with hypertrophic cardiomyopathy (HCM). However, the long-term effects of mild exercise on phenotypic expression in cardiomyopathy remain unclear. To evaluate the effects of exercise performed during infancy or adolescence in cardiomyopathic patients, cardiomyopathic Syrian hamsters (BIO14.6) were subjected to swimming. BIO14.6 and age-matched congenic normal hamsters (CN) as controls were divided into three groups: sedentary (Sed), and trained during infancy (Inf) and during adolescence (Ado). Histological and biochemical analysis of 41-week-old hamsters revealed that (1) the relative level of beta-myosin heavy chain mRNA was significantly lower in the Inf group than in the Sed and Ado groups of BIO14.6. The level in the Inf group of BIO14.6 was compatible with that in the age-matched Sed group of the CN strain; (2) in BIO14.6, degenerative mitochondrial change in the cardiomyocytes was not seen in the Inf group while it was common in the Sed and Ado groups; (3) calcineurin phosphatase activity in the swimming group in 10-week-old CN was significantly higher than that of the age-matched sedentary group, and was as much as that of the swimming and sedentary groups in 10- and 41-week-old BIO14.6.
journal_name
J Muscle Res Cell Motiljournal_title
Journal of muscle research and cell motilityauthors
Tatsuguchi M,Hiratsuka E,Machida S,Nishikawa T,Imamura S,Shimizu S,Nishimura M,Komuro I,Furutani Y,Furutani M,Nagao H,Komatsu K,Kasanuki H,Matsuoka Rdoi
10.1023/b:jure.0000021353.82449.9ekeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
69-76issue
1eissn
0142-4319issn
1573-2657journal_volume
25pub_type
杂志文章abstract：:Muscle development involves a complex sequence of time and spatially regulated cellular events leading to the formation of highly specialised syncytial muscle cells displaying a common feature, the capacity of contraction. Analyses of mechanisms controlling muscle development reveals that the main steps of muscle form...
journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00123361
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章,评审
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journal_title：Journal of muscle research and cell motility
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doi：10.1007/BF01738427
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abstract：:The pattern of expression of different types of myosin heavy chains and the development of different generations of muscle cells during foetal life were studied in four bovine muscles with widely varying characteristics, the Masseter, Longissimus thoracis, Cutaneus trunci and Diaphragma. Different complementary techni...
journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00122120
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00713271
更新日期：1981-09-01 00:00:00
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journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00711928
更新日期：1980-03-01 00:00:00
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00123833
更新日期：1994-02-01 00:00:00
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00114505
更新日期：1995-08-01 00:00:00
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章,评审
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00712090
更新日期：1982-12-01 00:00:00
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/s10974-004-4071-z
更新日期：2004-01-01 00:00:00
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/s10974-011-9256-7
更新日期：2011-09-01 00:00:00
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1023/a:1005356511634
更新日期：1998-02-01 00:00:00
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1023/a:1005671319604
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journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00711915
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abstract：:When skinned skeletal muscle fibres with rest sarcomere length (L = 2.5 microns) are compressed by the addition of various concentrations ([PVP]) of polyvinylpyrrolidine, the relation between the 1,0 spacing (d) of thick filament lattice and [PVP] has been known to break at d of around 35 nm, resulting in a steeper sl...
journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
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更新日期：1991-10-01 00:00:00
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journal_title：Journal of muscle research and cell motility
pub_type： 杂志文章
doi：10.1007/BF00712029
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