Abstract:
OBJECTIVES:To investigate the effects of strenuous exercise on commonly used biochemical and haematological variables in subjects running the 2002 London marathon. METHODS:34 healthy volunteers (7 female, 27 male) were recruited for the study. Blood was taken before the start (at registration) and immediately after completion of the marathon. Samples were analysed for urea and electrolytes, liver function tests, creatine kinase (CK), CK-MB isoenzyme, myoglobin, troponin I, full blood count, a clotting screen, and D-dimers. The results before and after exercise were compared. Pearson's correlation coefficients were calculated for all variables. RESULTS:Significant increases were found in CK, CK-MB, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and myoglobin following the marathon. However, there was no significant change in the level of troponin I. There was also evidence of activation of the coagulation and fibrinolytic cascades following the marathon, with a reduction in activated partial thromboplastin time, a reduction in fibrinogen, and an increase in D-dimers. CONCLUSIONS:The results confirm previous individual studies on marathon running and the biochemical and haematological tests routinely carried out in hospital. These are affected by prolonged exercise, and "abnormal" results in these tests may be normal after prolonged exercise and therefore not diagnostic of a disease process. The results of investigations in patients who have been exercising should be interpreted with caution.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
Smith JE,Garbutt G,Lopes P,Tunstall Pedoe Ddoi
10.1136/bjsm.2002.002873keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
292-4issue
3eissn
0306-3674issn
1473-0480journal_volume
38pub_type
杂志文章abstract::Twenty-five national kabaddi players (Asiad gold medalists 1990), mean age 27.91 years, who attended a national camp at the Sports Authority of India, Bangalore before the Beijing Asian Games in 1990, were investigated for their physical characteristics, body fat, lean body mass (LBM) and somatotype. The physiological...
journal_title:British journal of sports medicine
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-03-01 00:00:00
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pub_type: 传,历史文章,杂志文章
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更新日期:2012-06-01 00:00:00
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更新日期:2010-11-01 00:00:00
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更新日期:1991-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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