Abstract:
:The biotransformation of thionorphine (N-cyclopropylmethyl-7alpha-[(s)-1-hydroxy-1-methyl-3-(2thiophene)-propyl]-6,14-endo-ethano tetrahydrooripavine), a new analgesic, was in-vestigated in rats. The results of metabolite analysis by liquid chromatography/electrospray ionization tandem mass spectrometry with positive ion mode, in which a mobile phase of 10 mM ammonium acetate (pH 3.0)/acetonitrile (25/75) was used, suggested that thionorphine is biotransformed to two potentially active metabolites, the N-dealkylated thionorphine (M-I) and the oxidized thionorphine (M-II), and subsequently form conjugates with glucuronic acid of both thionorphine and the metabolites.
journal_name
Biopharm Drug Disposjournal_title
Biopharmaceutics & drug dispositionauthors
Wei SX,Zhang ZQ,Wang XY,Guo JFdoi
10.1002/bdd.360keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
117-26issue
3eissn
0142-2782issn
1099-081Xjournal_volume
25pub_type
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journal_title:Biopharmaceutics & drug disposition
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