Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro.

Abstract:

:Neural stem cells (NSCs) are currently considered powerful candidates for cell therapy in neurodegenerative disorders such as Parkinson's disease. However, it is not known when and how NSCs begin to differentiate functionally. Recent reports suggest that classical neurotransmitters such as acetylcholine (Ach) are involved in the proliferation and differentiation of neural progenitor cells, suggesting that neurotransmitters play an important regulatory role in development of the central nervous system (CNS). We have shown by calcium imaging and immunochemistry that proliferation and differentiation are enhanced by M2 muscarinic Ach receptors (mAchR) expressed on the NSC surface and on their neural progeny. Moreover, atropine, an mAchR antagonist, blocks the enhancement and inhibits the subsequent differentiation of NSCs. Further understanding of this neural-nutrition role of Ach might elucidate fetal brain development, the brain's response to injury, and learning and memory.

journal_name

Cell Biol Int

authors

Zhou C,Wen ZX,Shi DM,Xie ZP

doi

10.1016/j.cellbi.2003.10.005

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

63-7

issue

1

eissn

1065-6995

issn

1095-8355

pii

S1065699503002592

journal_volume

28

pub_type

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