Abstract:
:The formation of landomycin A or one of its derivatives (5,6-anhydrolandomycin A) in a heterologous strain has never been achieved. It has now been made possible by the coexpression of a cosmid containing all biosynthetic genes necessary to produce landomycin A together with a pathway-specific regulatory gene. As host we used a polyketide synthase-defective mutant strain of Streptomyces fradiae Tü2717 which is not able to produce urdamycin A. Our results indicate that four glycosyltransferases are responsible for the formation of the hexasaccharide side chain of landomycin A.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
von Mulert U,Luzhetskyy A,Hofmann C,Mayer A,Bechthold Adoi
10.1016/S0378-1097(03)00861-9keywords:
subject
Has Abstractpub_date
2004-01-15 00:00:00pages
91-7issue
1eissn
0378-1097issn
1574-6968pii
S0378109703008619journal_volume
230pub_type
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