A gravitationally lensed quasar with quadruple images separated by 14.62 arcseconds.

abstract：:'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo...

journal_title：Nature

authors： Sutcliffe JG,Milner RJ,Gottesfeld JM,Lerner RA

更新日期：1984-03-15 00:00:00

abstract：: ...

journal_title：Nature

authors： Zunger A

更新日期：2019-02-01 00:00:00

abstract：:Emerging infectious diseases present a formidable challenge to the conservation of native species in the twenty-first century. Diseases caused by introduced pathogens have had large impacts on species abundances, including the American chestnut, Hawaiian bird species and many amphibians. Changes in host population siz...

journal_title：Nature

authors： LaDeau SL,Kilpatrick AM,Marra PP

更新日期：2007-06-07 00:00:00

abstract：:Fibres in the mammalian optic nerve are generally thought to be organised retinotopically. Recording electrophysiologically from the cat optic nerve, we found little evidence to support this notion, which led us to investigate the problem by anatomical methods. We made a localised injection of horseradish peroxidase i...

journal_title：Nature

authors： Horton JC,Greenwood MM,Hubel DH

更新日期：1979-12-13 00:00:00

abstract：:Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea. A decrease in nitrogen flux through ASS1 in the liver causes the urea cycle disorder citrullinaemia...

journal_title：Nature

authors： Rabinovich S,Adler L,Yizhak K,Sarver A,Silberman A,Agron S,Stettner N,Sun Q,Brandis A,Helbling D,Korman S,Itzkovitz S,Dimmock D,Ulitsky I,Nagamani SC,Ruppin E,Erez A

更新日期：2015-11-19 00:00:00

abstract：:Self-incompatibility in flowering plants is often controlled by a single nuclear gene (the S-gene) having several alleles. This gene prevents fertilization by self-pollen or by pollen bearing either of the two S-alleles expressed in the style. Sequence analysis shows that three alleles of the S gene of Nicotiana alata...

journal_title：Nature

authors： McClure BA,Haring V,Ebert PR,Anderson MA,Simpson RJ,Sakiyama F,Clarke AE

更新日期：1989-12-21 00:00:00

abstract：:Nuclear-architecture defects have been shown to correlate with the manifestation of a number of human diseases as well as ageing. It is therefore plausible that diseases whose manifestations correlate with ageing might be connected to the appearance of nuclear aberrations over time. We decided to evaluate nuclear orga...

journal_title：Nature

authors： Liu GH,Qu J,Suzuki K,Nivet E,Li M,Montserrat N,Yi F,Xu X,Ruiz S,Zhang W,Wagner U,Kim A,Ren B,Li Y,Goebl A,Kim J,Soligalla RD,Dubova I,Thompson J,Yates J 3rd,Esteban CR,Sancho-Martinez I,Izpisua Belmonte JC

更新日期：2012-11-22 00:00:00

abstract：:Surgical, pharmacological and genetic lesion studies have revealed distinct anatomical sites involved with different forms of learning. Studies of patients with localized brain damage and work in rodent model systems, for example, have shown that the hippocampal formation participates in acquisition of declarative tas...

journal_title：Nature

authors： Dubnau J,Grady L,Kitamoto T,Tully T

更新日期：2001-05-24 00:00:00

abstract：:When we reach towards an object that suddenly appears in our peripheral visual field, not only does our arm extend towards the object, but our eyes, head and body also move in such a way that the image of the object falls on the fovea. Popular models of how reaching movements are programmed have argued that while the ...

journal_title：Nature

authors： Goodale MA,Pelisson D,Prablanc C

更新日期：1986-04-24 00:00:00

abstract：:The crab Xenograpsus testudinatus lives at enormously high densities around the sulphur-rich hydrothermal vents found in shallow waters off Taiwan, even though this acidic environment is low in nutrients. Here we show that these crabs swarm out of their crevices at slack water and feed on the vast numbers of zooplankt...

journal_title：Nature

authors： Jeng MS,Ng NK,Ng PK

更新日期：2004-12-23 00:00:00

abstract：:Oligomerization of membrane proteins in response to lipid binding has a critical role in many cell-signalling pathways but is often difficult to define or predict. Here we report the development of a mass spectrometry platform to determine simultaneously the presence of interfacial lipids and oligomeric stability and ...

journal_title：Nature

authors： Gupta K,Donlan JAC,Hopper JTS,Uzdavinys P,Landreh M,Struwe WB,Drew D,Baldwin AJ,Stansfeld PJ,Robinson CV

更新日期：2017-01-19 00:00:00

abstract：:Little is known about the biochemical or functional nature of the proteins encoded by the bcl-2 gene, which undergoes chromosomal translocation in approximately 85% of follicular lymphoma, 20% of diffuse large cell lymphoma and 10% of chronic lymphocytic leukaemia of B cells. Translocation of bcl-2 sequences from chro...

journal_title：Nature

authors： Haldar S,Beatty C,Tsujimoto Y,Croce CM

更新日期：1989-11-09 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the population worldwide and has severe effects on patients' physical and psychological well-being. The discovery that psoriasis is an immune-mediated disease has led to more targeted, effective therapies; recent advances have focused...

journal_title：Nature

authors： Kopp T,Riedl E,Bangert C,Bowman EP,Greisenegger E,Horowitz A,Kittler H,Blumenschein WM,McClanahan TK,Marbury T,Zachariae C,Xu D,Hou XS,Mehta A,Zandvliet AS,Montgomery D,van Aarle F,Khalilieh S

更新日期：2015-05-14 00:00:00

abstract：:Hox genes are essential for growth and patterning of the tetrapod limb skeleton. Mice mutant for the Hoxd-13 gene have an important delay in morphogenesis owing to reduced proliferation. Based on the appearance of atavisms in such mice, we suggested that modifications of Hox gene regulation may have been a source of m...

journal_title：Nature

authors： Sordino P,van der Hoeven F,Duboule D

更新日期：1995-06-22 00:00:00

abstract：:Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in disease pathogenesis and enable the discovery of therapeutic targets, ...

journal_title：Nature

authors： Ramachandran P,Dobie R,Wilson-Kanamori JR,Dora EF,Henderson BEP,Luu NT,Portman JR,Matchett KP,Brice M,Marwick JA,Taylor RS,Efremova M,Vento-Tormo R,Carragher NO,Kendall TJ,Fallowfield JA,Harrison EM,Mole DJ,Wigmore SJ

更新日期：2019-11-01 00:00:00

abstract：:Spin dynamics in antiferromagnets has much shorter timescales than in ferromagnets, offering attractive properties for potential applications in ultrafast devices1-3. However, spin-current generation via antiferromagnetic resonance and simultaneous electrical detection by the inverse spin Hall effect in heavy metals h...

journal_title：Nature

authors： Li J,Wilson CB,Cheng R,Lohmann M,Kavand M,Yuan W,Aldosary M,Agladze N,Wei P,Sherwin MS,Shi J

更新日期：2020-02-01 00:00:00

abstract：:Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge...

journal_title：Nature

authors： Kaiser TS,Poehn B,Szkiba D,Preussner M,Sedlazeck FJ,Zrim A,Neumann T,Nguyen LT,Betancourt AJ,Hummel T,Vogel H,Dorner S,Heyd F,von Haeseler A,Tessmar-Raible K

更新日期：2016-12-01 00:00:00

abstract：:Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring abou...

journal_title：Nature

authors： Pavelka N,Rancati G,Zhu J,Bradford WD,Saraf A,Florens L,Sanderson BW,Hattem GL,Li R

更新日期：2010-11-11 00:00:00

abstract：:Through their functional diversification, distinct lineages of CD4(+) T cells can act to either drive or constrain immune-mediated pathology. Transcription factors are critical in the generation of cellular diversity, and negative regulators antagonistic to alternate fates often act in conjunction with positive regula...

journal_title：Nature

authors： Roychoudhuri R,Hirahara K,Mousavi K,Clever D,Klebanoff CA,Bonelli M,Sciumè G,Zare H,Vahedi G,Dema B,Yu Z,Liu H,Takahashi H,Rao M,Muranski P,Crompton JG,Punkosdy G,Bedognetti D,Wang E,Hoffmann V,Rivera J,Marincol

更新日期：2013-06-27 00:00:00

abstract：:Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independent of the general recombination functions of the host. The mechanisms proposed generally involve a staggered do...

journal_title：Nature

authors： Murphy E,Löfdahl S

更新日期：1984-01-19 00:00:00

abstract：:A soluble enzyme system has been discovered which specifically recognizes and replicates plasmids containing the Escherichia coli chromosomal origin, oriC. Electron microscopy has shown that plasmid replication begins at or near oriC from which it progresses bidirectionally to completion. Control of initiation of a cy...

journal_title：Nature

authors： Kaguni JM,Fuller RS,Kornberg A

更新日期：1982-04-15 00:00:00

abstract：:Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-ex...

journal_title：Nature

authors： Zhang Z,Zhang Y,Xia S,Kong Q,Li S,Liu X,Junqueira C,Meza-Sosa KF,Mok TMY,Ansara J,Sengupta S,Yao Y,Wu H,Lieberman J

更新日期：2020-03-01 00:00:00

abstract：:Tuberculosis remains second only to HIV/AIDS as the leading cause of mortality worldwide due to a single infectious agent. Despite chemotherapy, the global tuberculosis epidemic has intensified because of HIV co-infection, the lack of an effective vaccine and the emergence of multi-drug-resistant bacteria. Alternative...

journal_title：Nature

authors： Mayer-Barber KD,Andrade BB,Oland SD,Amaral EP,Barber DL,Gonzales J,Derrick SC,Shi R,Kumar NP,Wei W,Yuan X,Zhang G,Cai Y,Babu S,Catalfamo M,Salazar AM,Via LE,Barry CE 3rd,Sher A

更新日期：2014-07-03 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are activity-dependent changes in synaptic strength that may serve as the cellular mechanisms of information storage in the vertebrate brain. The mossy fibre-CA3 synapse displays NMDA (M-methyl-D-aspartate) receptor-independent forms of LTP and LTD that were ...

journal_title：Nature

authors： Derrick BE,Martinez JL Jr

更新日期：1996-05-30 00:00:00

abstract：:During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalli...

journal_title：Nature

authors： Lee JS,Hnilova M,Maes M,Lin YC,Putarjunan A,Han SK,Avila J,Torii KU

更新日期：2015-06-25 00:00:00

abstract：:An important step towards understanding the molecular basis of the functional diversity of voltage-gated K+ channels in the mammalian brain has been the discovery of a family of genes encoding rat brain K+ channel-forming (RCK) proteins. All species of these RCK proteins form homomultimeric voltage-gated K+ channels w...

journal_title：Nature

authors： Ruppersberg JP,Schröter KH,Sakmann B,Stocker M,Sewing S,Pongs O

更新日期：1990-06-07 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors (NMDARs) are a major class of excitatory neurotransmitter receptors in the central nervous system. They form glutamate-gated ion channels that are highly permeable to calcium and mediate activity-dependent synaptic plasticity. NMDAR dysfunction is implicated in multiple brain diso...

journal_title：Nature

authors： Gielen M,Siegler Retchless B,Mony L,Johnson JW,Paoletti P

更新日期：2009-06-04 00:00:00

abstract：:Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of intra-tumour diversification, we characterized organoids derived from multiple single cells from thr...

journal_title：Nature

authors： Roerink SF,Sasaki N,Lee-Six H,Young MD,Alexandrov LB,Behjati S,Mitchell TJ,Grossmann S,Lightfoot H,Egan DA,Pronk A,Smakman N,van Gorp J,Anderson E,Gamble SJ,Alder C,van de Wetering M,Campbell PJ,Stratton MR,Clevers

更新日期：2018-04-01 00:00:00

abstract：:The neurohypophysial hormone vasopressin exerts antidiuretic, vasopressor and behavioural effects (for example, facilitation of memory processes). Vasopressin may alter animal behaviour via direct effect on brain processes. Recently, however, it has been suggested that vasopressin acts mainly at peripheral receptor sy...

journal_title：Nature

authors： de Wied D,Gaffori O,van Ree JM,de Jong W

更新日期：1984-03-15 00:00:00

abstract：:Human immunodeficiency virus 1 (HIV-1) is the aetiological agent of AIDS. The virus establishes lytic, latent and non-cytopathic productive infection in cells in culture. The complexity of virus-host cell interaction is reflected in the complex organization of the viral genome. In addition to the genes that encode the...

journal_title：Nature

authors： Cohen EA,Terwilliger EF,Sodroski JG,Haseltine WA

更新日期：1988-08-11 00:00:00