Abstract:
:Essential genes are genes that are indispensable to support cellular life. These genes constitute a minimal gene set required for a living cell. We have constructed a Database of Essential Genes (DEG), which contains all the essential genes that are currently available. The functions encoded by essential genes are considered a foundation of life and therefore are likely to be common to all cells. Users can BLAST the query sequences against DEG. If homologous genes are found, it is possible that the queried genes are also essential. Users can search for essential genes by their function or name. Users can also browse and extract all the records in DEG. Essential gene products comprise excellent targets for antibacterial drugs. Analysis of essential genes could help to answer the question of what are the basic functions necessary to support cellular life. DEG is freely accessible from the website http://tubic.tju.edu.cn/deg/.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Zhang R,Ou HY,Zhang CTdoi
10.1093/nar/gkh024keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
D271-2issue
Database issueeissn
0305-1048issn
1362-4962pii
32/suppl_1/D271journal_volume
32pub_type
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/gkv469
更新日期:2015-06-23 00:00:00
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pub_type: 杂志文章
doi:10.1093/nar/5.6.1801
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/24.21.4249
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/8.6.1187
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doi:10.1093/nar/11.12.3989
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journal_title:Nucleic acids research
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更新日期:2009-04-01 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
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更新日期:1982-09-25 00:00:00
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pub_type: 杂志文章
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journal_title:Nucleic acids research
pub_type: 杂志文章
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更新日期:2005-08-10 00:00:00
abstract::We have developed an HIV nef-Escherichia coli lacZ fusion system in vitro that allows the detection of low frequency mutations, including frameshifts, deletions and insertions. A portion of the nef gene that encompasses a hypervariable region was fused in-frame with a downstream lacZalpha peptide coding region. The re...
journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/24.9.1710
更新日期:1996-05-01 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/15.16.6607
更新日期:1987-08-25 00:00:00
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abstract::The D. melanogaster Adh gene is transcribed from two different promoters; a proximal (larval) promoter is active during late embryonic and larval stages, and a distal (adult) promoter is active primarily in third instar larvae and in adult flies (1). Genetic analyses suggest that several species of the mulleri subgrou...
journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/13.19.6899
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/8.12.2725
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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更新日期:2020-05-07 00:00:00
abstract::Site-specific DNA double-strand breaks have been used to generate knock-in through the homology-dependent or -independent pathway. However, low efficiency and accompanying negative impacts such as undesirable indels or tumorigenic potential remain problematic. In this study, we present an enhanced reduced-risk genome ...
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更新日期:2020-06-04 00:00:00