Radiation dose intensification in limited-stage small-cell lung cancer.

Abstract:

:Multiple studies have confirmed the value of radiation therapy in limited-stage small-cell lung cancer. The appropriate dose of radiation and the optimal fractionation scheme, however, remain controversial. This article will examine the history of radiation therapy in the management of small-cell lung cancer. It will review the rationale for the various approaches to radiation dose intensification, and review the results of important trials investigating the issue of radiation dose in the management of this disease. Survival outcomes and toxicity of various approaches to radiation dose intensification, including dose escalation and hyperfractionation, will be assessed. The implications of advancements in technology will be examined, and the optimal design of future trials will be discussed.

journal_name

Clin Lung Cancer

journal_title

Clinical lung cancer

authors

Roof KS,Fidias P,Lynch TJ,Choi NC

doi

10.3816/clc.2003.n.013

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

339-46

issue

6

eissn

1525-7304

issn

1938-0690

pii

S1525-7304(11)70303-5

journal_volume

4

pub_type

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