Abstract:
:The tprK gene of Treponema pallidum subsp. pallidum, the causative agent of venereal syphilis, belongs to a 12-member gene family and encodes a protein with a predicted cleavable signal sequence and predicted transmembrane domains. Except for the Nichols type strain, all rabbit-propagated isolates of T. pallidum examined thus far are comprised of mixed populations of organisms with heterogeneous tprK sequences. We show that tprK sequences in treponemes obtained directly from syphilis patients are also heterogeneous. Clustering analysis demonstrates that primary chancre tprK sequences are more likely to cluster within a sample than among samples and that tighter clustering is seen within chancre samples than within rabbit-propagated isolates. Closer analysis of tprK sequences from a rabbit-propagated isolate reveals that individual variable regions have different levels of diversity, suggesting that variable regions may have different intrinsic rates of sequence change or may be under different levels of selection. Most variable regions show increased sequence diversity upon passage. We speculate that the diversification of tprK during infection allows organisms to evade the host immune response, contributing to reinfection and persistent infection.
journal_name
J Bacterioljournal_title
Journal of bacteriologyauthors
LaFond RE,Centurion-Lara A,Godornes C,Rompalo AM,Van Voorhis WC,Lukehart SAdoi
10.1128/jb.185.21.6262-6268.2003keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
6262-8issue
21eissn
0021-9193issn
1098-5530journal_volume
185pub_type
杂志文章abstract::Burkholderia pseudomallei, the causative agent of melioidosis, contains a large pathogen genome (7.2 Mb) with ∼2,000 genes of putative or unknown function. Interactions with potential hosts and environmental factors may induce rapid adaptations in these B. pseudomallei genes, which can be discerned through evolutionar...
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journal_title:Journal of bacteriology
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journal_title:Journal of bacteriology
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journal_title:Journal of bacteriology
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journal_title:Journal of bacteriology
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更新日期:1968-05-01 00:00:00
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更新日期:2004-05-01 00:00:00
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更新日期:1998-01-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/jb.177.14.3911-3916.1995
更新日期:1995-07-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
doi:10.1128/JB.149.2.768-770.1982
更新日期:1982-02-01 00:00:00
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journal_title:Journal of bacteriology
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更新日期:1966-01-01 00:00:00
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journal_title:Journal of bacteriology
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更新日期:1986-03-01 00:00:00
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更新日期:2012-03-01 00:00:00
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journal_title:Journal of bacteriology
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更新日期:1988-11-01 00:00:00
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journal_title:Journal of bacteriology
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更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1976-10-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
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journal_title:Journal of bacteriology
pub_type: 杂志文章
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更新日期:1986-04-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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journal_title:Journal of bacteriology
pub_type: 杂志文章
doi:10.1128/JB.148.2.600-609.1981
更新日期:1981-11-01 00:00:00
abstract::The region of the colicin E1 polypeptide that interacts with immunity protein has been localized to a 168-residue COOH-terminal peptide. This is the length of a proteolytically generated peptide fragment of colicin E1 against which imm+ function can be demonstrated in osmotically shocked cells. The role of particular ...
journal_title:Journal of bacteriology
pub_type: 杂志文章
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更新日期:1985-10-01 00:00:00