Abstract:
:New chemical entities are routinely screened in vitro and in vivo for their ability to induce cytochrome P450s (CYP), other drug-metabolizing enzymes and possibly transporters in an attempt to more accurately predict clinical parameters such as drug-drug interactions and clearance in humans. Some of these potential therapeutic agents can cause induction of the metabolism of another molecule or auto-induction thereby increasing their own metabolism and elimination, as well as potentially any molecules metabolized by the same enzyme(s). Key CYPs in the 1A, 2B, 2C, and 3A families have all been shown to be inducible. It would be clearly advantageous to know the potential for a compound to induce drug metabolizing enzymes or transporters prior to clinical development, and many in vitro systems have been developed for this purpose. Newer computational technologies are also being applied in order to attempt to predict induction from the molecular structure alone before a molecule is even synthesized or tested. This review will cover the various in vitro and in silico methods developed for prediction of key inducers of CYPs and other proteins, as well as the limitations of such technologies and applications in the future.
journal_name
Curr Drug Metabjournal_title
Current drug metabolismauthors
Mankowski DC,Ekins Sdoi
10.2174/1389200033489352keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
381-91issue
5eissn
1389-2002issn
1875-5453journal_volume
4pub_type
杂志文章,评审abstract::Maternal antenatal therapy with glucocorticoids (GC) is routinely used to prevent lung immaturity. The potential harmful effects on other organs, including in particular the central nervous system (CNS), are still controversial. In the present review we aimed to investigate: i) the beneficial and detrimental effects o...
journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:
更新日期:2013-02-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/1389200219666180925094515
更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/1389200217666160125113806
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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更新日期:2005-04-01 00:00:00
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更新日期:2006-05-01 00:00:00
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pub_type: meta分析
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更新日期:2020-01-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/1389200033489235
更新日期:2003-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 临床试验,杂志文章
doi:10.2174/138920006778520561
更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章
doi:10.2174/1389200221999210101233340
更新日期:2021-01-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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更新日期:2012-02-01 00:00:00
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Current drug metabolism
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更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00