Abstract:
:To understand the integrin requirements of T-helper (T(H)) effector subsets, we investigated the contribution of CD18 (beta(2) integrin) to T(H)1 and T(H)2 function in vitro and in relevant disease models. CD18-deficient (Itgb2(-/-)) T cells showed largely normal in vitro function. Compared with wild-type mice, Itgb2(-/-) mice were better able to resolve Leishmania major infection and generated a superior T(H)1 immune response, as assessed from draining lymph nodes. In contrast, T(H)2-dependent allergic lung disease was markedly impaired in mutant mice. In both models, development of T(H)1 and T(H)2 cells in spleens was normal, but accumulation of T(H)2 (not T(H)1) cells at inflammatory sites was reduced. Thus, CD18 is selectively required for T(H)2, but not T(H)1, homing and has a minimal influence on T-effector development. These findings suggest a new integrin-based therapeutic approach in which the outcomes of diverse diseases may be favorably influenced by altering the homing of T(H)2 cells.
journal_name
Nat Medjournal_title
Nature medicineauthors
Lee SH,Prince JE,Rais M,Kheradmand F,Shardonofsky F,Lu H,Beaudet AL,Smith CW,Soong L,Corry DBdoi
10.1038/nm932keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
1281-6issue
10eissn
1078-8956issn
1546-170Xpii
nm932journal_volume
9pub_type
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