Zymosan induces selective release of arachidonic acid from rabbit alveolar macrophages via stimulation of a beta-glucan receptor.

Abstract:

:Zymosan, which is composed primarily of alpha-mannan and beta-glucan polymers, is a well recognized activator of macrophages. The type receptor by which unopsonized zymosan induces arachidonic acid release was investigated. It was found that particulate beta-glucan and zymosan stimulated an identical dose-dependent release of arachidonic acid. This release of arachidonic acid by zymosan was blocked by soluble beta-glucans whereas soluble mannan had no effect. This inhibition was not due to a general toxic effect of the soluble beta-glucans as they had no effect on calcium ionophore-induced release of arachidonic acid. Beta-glucan-induced fatty acid release from these cells was shown to be fairly specific for arachidonic acid. These data reveal that zymosan stimulates the specific release of arachidonic acid from rabbit alveolar macrophages, at least in part, via a beta-glucan receptor.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Daum T,Rohrbach MS

doi

10.1016/0014-5793(92)81077-y

keywords:

subject

Has Abstract

pub_date

1992-09-07 00:00:00

pages

119-22

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(92)81077-Y

journal_volume

309

pub_type

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