Abstract:
:Zymosan, which is composed primarily of alpha-mannan and beta-glucan polymers, is a well recognized activator of macrophages. The type receptor by which unopsonized zymosan induces arachidonic acid release was investigated. It was found that particulate beta-glucan and zymosan stimulated an identical dose-dependent release of arachidonic acid. This release of arachidonic acid by zymosan was blocked by soluble beta-glucans whereas soluble mannan had no effect. This inhibition was not due to a general toxic effect of the soluble beta-glucans as they had no effect on calcium ionophore-induced release of arachidonic acid. Beta-glucan-induced fatty acid release from these cells was shown to be fairly specific for arachidonic acid. These data reveal that zymosan stimulates the specific release of arachidonic acid from rabbit alveolar macrophages, at least in part, via a beta-glucan receptor.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Daum T,Rohrbach MSdoi
10.1016/0014-5793(92)81077-ykeywords:
subject
Has Abstractpub_date
1992-09-07 00:00:00pages
119-22issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(92)81077-Yjournal_volume
309pub_type
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