Abstract:
:In rats, CL-Brener clone caused high mortality, severe acute myocarditis, and myositis that subsided completely in surviving animals. Accordingly, no parasite kDNA could be amplified in several organs after 4 months. The monoclonal JG strain caused null mortality, acute predominantly focal myocarditis, discrete and focal myositis, and a chronic phase with sparse inflammatory foci. Double infection with both Trypanosoma cruzi populations turned mortality very low or null. At the end of the acute phase, the heart exhibited only JG strain kDNA (LSSP-PCR), while skeletal muscles and rectum exhibited only CL-Brener kDNA. Molecular and histopathological findings were accordant. In double infection chronic phase, JG strain remains in heart and appeared in organs previously parasitized by CL-Brener clone. Understanding the virulence and histotropism shifts now described could be important to clarify the variable clinical course and epidemiological peculiarities of Chagas' disease.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Franco DJ,Vago AR,Chiari E,Meira FC,Galvão LM,Machado CRdoi
10.1016/s0014-4894(03)00119-xkeywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
54-61issue
1-2eissn
0014-4894issn
1090-2449pii
S001448940300119Xjournal_volume
104pub_type
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
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journal_title:Experimental parasitology
pub_type: 杂志文章
doi:10.1016/j.exppara.2005.09.006
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journal_title:Experimental parasitology
pub_type: 杂志文章
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journal_title:Experimental parasitology
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pub_type: 杂志文章
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