Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis.

Abstract:

:This review focuses on the signaling system involving the Angiopoietin1/Tie2 receptor, which appears to be involved in the secondary stages of blood vessel formation. Although this system is crucial for blood and lymphatic vessel formation, identifying its precise role in embryonic and adult vascular biology has been a major challenge. The evidence for the key role of the Angiopoietin/Tie system is discussed, and some of the other members of the system (Ang2, Tie1) are mentioned. A comparison is made with the VEGF signaling system, which seems to provide a complementary, and somewhat more tractable, signaling system. Some of the basic unanswered questions concerning Tie/Angiopoietin biology and the secondary stages of blood vessel formation are also highlighted.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Thurston G

doi

10.1007/s00441-003-0749-6

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

61-8

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

314

pub_type

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