Changes in genetic types and population dynamics of Moraxella catarrhalis in hospitalized children are not associated with an exacerbation of existing disease.

Abstract:

:Pulsed-field gel electrophoresis typing was performed on a retrospective set of 129 Moraxella catarrhalis isolates obtained over a 20 month period from 70 children admitted to, or presenting at, the Erasmus University Medical Center, Rotterdam, The Netherlands. The mean age of the children (at the end of the study) was 2.5 years, with a range of 6 months to 15 years. Fifty-one different M. catarrhalis types were isolated from the hospitalized children, with 31 % (22/70) being infected with two particularly prevalent M. catarrhalis types. These two prevalent types also exhibited different protein profiles. The majority (72%; 16/22) of the children infected with these two predominant types had spent at least 1 week on two paediatric intensive care wards. No exacerbation of existing disease or new disease was observed in children who experienced M. catarrhalis type changes.

journal_name

J Med Microbiol

authors

Hays JP,Eadie K,Verduin CM,Hazelzet J,Verbrugh H,van Belkum A

doi

10.1099/jmm.0.05251-0

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

815-820

issue

Pt 9

eissn

0022-2615

issn

1473-5644

journal_volume

52

pub_type

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