Abstract:
:Although the immune system can clearly recognize cancer cells, there is little evidence that it does so to any effective consequence in patients with advanced breast cancer. The possibility of effective control of micrometastatic disease remains but is unproven. The challenge for the clinician is to find ways to enhance the ability of a patient's own immune system to recognize and effectively target malignant cells. It is clear that there is no shortage of target antigens for immune cell recognition of breast cancer but it is less certain whether the route to an effective therapeutic strategy lies with enhanced recognition of an individual target or a more general route to enhanced immune cell activation.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Cameron DAdoi
10.1586/14760584.1.1.29keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
29-34issue
1eissn
1476-0584issn
1744-8395pii
ERV010105journal_volume
1pub_type
杂志文章,评审abstract::This section deals with how new knowledge of the development of cellular immunity in the neonatal period informs vaccine development and reviews the immune responses of the most vulnerable group of newborns, those born prematurely, to vaccines. It describes how the development of future vaccine strategies relies on a ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.3.4.339
更新日期:2004-08-01 00:00:00
abstract::While vaccination continues to be the most successful interventionist health policy to date, infectious disease remains a significant cause of death worldwide. A primary reason that vaccination is not able to generate effective immunity is a lack of appropriate adjuvants capable of initiating the desired immune respon...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.4.559
更新日期:2007-08-01 00:00:00
abstract::Optimal vaccine efficacy requires not only a protective antigen, but also a strong immune activator as an adjuvant. Most viral vaccines, such as influenza vaccines and nonviral genetic vaccines (e.g., DNA vaccines), contain nucleic acids, which appear to act as essential 'built-in' adjuvants. Specific receptors, inclu...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.09.57
更新日期:2009-08-01 00:00:00
abstract:INTRODUCTION:Pneumococcal conjugate vaccine (PCV) impact studies have reported substantial reductions in the incidence of invasive pneumococcal disease (IPD) after implementation of childhood PCV programs. Heterogeneity in surveillance systems, local epidemiology and PCV programs hampers comparisons between studies. We...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2018.1413354
更新日期:2018-06-01 00:00:00
abstract::The WHO has recently recommended the inclusion of rotavirus vaccine in the national immunization programs of all countries. In countries in the Americas, Europe and Australia that have adopted routine childhood immunization against rotavirus, significant reductions in the burden of severe childhood diarrhea have been ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.17
更新日期:2010-04-01 00:00:00
abstract::C-type lectin receptors (CLRs) are a class of pathogen-recognition receptors that are actively investigated in the field of vaccine delivery. Many of their properties have functions linked to the immune system. These receptors are expressed abundantly on antigen-presenting cells and are considered to be the sentinels ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.7.1005
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Hepatitis A and B are two of the most common vaccine-preventable diseases and vaccination for Hepatitis A virus (HAV) and hepatitis B virus (HBV) is recommended for those at risk of contracting HAV and/or HBV through their occupation, travel or lifestyle. OBJECTIVE:To describe the vaccine efficacy, immunoge...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2016.1150182
更新日期:2016-07-01 00:00:00
abstract::Pneumococcal disease is a major health problem worldwide. Large, rapid declines in overall invasive pneumococcal disease and mucosal disease in children, reductions in vaccine-type disease in unvaccinated children and adults (indirect effects) and significant drops in antibiotic-resistant infections were observed afte...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.9.1367
更新日期:2008-11-01 00:00:00
abstract::Conventional virus-like particles are usually composed of a single structural protein which spontaneously assembles into particles. L-particles, a little-known type of virus-like particle, are produced as part of the natural infectious process of many, if not all, alpha-herpesviruses. L-particles lack the nucleocapsid...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.1.4.427
更新日期:2002-12-01 00:00:00
abstract::Psychological stress has been shown to be associated with poorer antibody levels following vaccination in both animals and humans, although the mechanisms underlying this relationship remain unclear. However, animal research has enabled investigation of how this relationship may be affected by the influence of individ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.3.2.141
更新日期:2004-04-01 00:00:00
abstract::Ebola hemorrhagic fever is one of the most fatal viral diseases worldwide affecting humans and nonhuman primates. Although infections only occur frequently in Central Africa, the virus has the potential to spread globally and is classified as a category A pathogen that could be misused as a bioterrorism agent. As of t...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2014.885841
更新日期:2014-04-01 00:00:00
abstract::Highly renowned in the vaccines world, Stanley A. Plotkin has worked at many leading institutions throughout his career, and is Emeritus Professor of the University of Pennsylvania and Adjunct Professor of the Johns Hopkins University. In 1991, Plotkin joined Sanofi Pasteur and worked there from 1991 to 1997, and now ...
journal_title:Expert review of vaccines
pub_type: 面试
doi:10.1586/14760584.2014.934678
更新日期:2014-08-01 00:00:00
abstract::The approval of sipuleucel-T has placed cancer vaccines on the verge of becoming an effective modality. However, there is much to define to understand the intricacies from the multiple confounding factors in vaccine immunotherapy. In this article under review, some patients with metastatic cancer who had limited tumor...
journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
doi:10.1586/erv.11.193
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION:Due to overcome the hardness of the vaccine design, computational vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing analysis, antigenicity analysis, population coverage, conservancy analysis, allergenicity assessment, toxicity prediction, and protein-peptide docki...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2020.1794832
更新日期:2020-08-01 00:00:00
abstract::Plant viruses are emerging as an attractive alternative to stable genetic transformation for the expression of foreign proteins in plants. The main advantages of using this strategy are that viral genomes are small and easy to manipulate, infection of plants with modified viruses is simpler and quicker than the regene...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.4.5.687
更新日期:2005-10-01 00:00:00
abstract::Humanitarian aid workers regularly encounter the challenge of setting up functioning surveillance systems immediately after a disaster. Detecting potential outbreaks of diseases, such as cholera, that might arise from disturbed living conditions, displacement and lack of clean water and sanitation is, therefore, extre...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.7.4.431
更新日期:2008-05-01 00:00:00
abstract::In the Second Conference on Controversies in Vaccination in Adults, leading vaccine experts among manufacturers, physicians, microbiologists, virologists, immunologists and public health specialists came together to discuss recent approaches, developments and strategies in vaccination against worldwide pressing epidem...
journal_title:Expert review of vaccines
pub_type:
doi:10.1586/erv.13.44
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:Human metapneumovirus (hMPV) has become one of the major pathogens causing acute respiratory infections (ARI) mainly affecting young children, immunocompromised patients, and the elderly. Currently there are no licensed vaccines against this virus. Areas covered: Since the discovery of hMPV in 2001, many g...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2017.1283223
更新日期:2017-05-01 00:00:00
abstract::Toxoplasma gondii, a significant public health risk, is able to infect almost all warm-blooded animals including humans, and it results in economic losses in production animals. In the last three years, a large number of vaccination experiments have been performed to control T. gondii infection, with the target of lim...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.1098539
更新日期:2015-01-01 00:00:00
abstract::Due to distinct immunological limitations, both infants and elderly individuals are highly susceptible to Streptococcus pneumoniae. Routine immunization of children with the conjugate vaccine over the past decade has substantially reduced incidence of vaccine-serotype related invasive pneumococcal disease in both vacc...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.963058
更新日期:2015-01-01 00:00:00
abstract::Active immunotherapy aimed at the stimulation of tumor-specific T cells has established itself within the clinic as a therapeutic option to treat cancer. One strategy is the use of so-called peptides that mimic genuine T-cell epitopes as vaccines to activate tumor-specific T cells. In various clinical trials, differen...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2014.862499
更新日期:2014-01-01 00:00:00
abstract::As the Global Polio Eradication Initiative progresses toward the eradication of wild polioviruses, national and global health leaders must still actively consider options for managing poliovirus risks, including risks associated with using oral poliovirus vaccine. Oral poliovirus vaccine continues to represent a highl...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.195
更新日期:2012-04-01 00:00:00
abstract::Dengue virus is the most significant arboviral pathogen worldwide with nearly 400 million infections annually and half the global population at risk of disease. Despite this tremendous public health burden, there are no licensed treatments or vaccines to prevent dengue in humans. Results from clinical trials of leadin...
journal_title:Expert review of vaccines
pub_type: 社论
doi:10.1586/14760584.2015.961431
更新日期:2015-01-01 00:00:00
abstract::Lipopolysaccharide (LPS), a dominant component of the Gram-negative bacterial outer membrane, is a strong activator of the innate immune system, and thereby an important determinant in the adaptive immune response following bacterial infection. This adjuvant activity can be harnessed following immunization with bacter...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.1026808
更新日期:2015-06-01 00:00:00
abstract::Several new lyssaviruses have emerged in the past decade and it is likely that more remain to be discovered. There are six recognized genotypes of lyssavirus other than the rabies virus (genotype 1). All but one of these has been associated with human cases, with the resulting disease clinically similar to rabies. Rab...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.4.4.533
更新日期:2005-08-01 00:00:00
abstract::Prostate cancer is the second leading cause of cancer-related death among men in the USA. Vaccine strategies represent a novel therapeutic approach. One potential target for a prostate cancer vaccine is prostate-specific antigen, owing to its restricted expression in prostate cancer and normal prostatic epithelial cel...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.5.2.199
更新日期:2006-04-01 00:00:00
abstract::Influenza inflicts significant global mortality and morbidity that can be combated by effective immunization. However, the protective efficacy of current vaccines is limited by both the significant antigenic diversity of the viral hemagglutinin protein and the capacity for rapid antigenic change. This necessitates glo...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.1068125
更新日期:2015-01-01 00:00:00
abstract::Plants offer an attractive alternative for the production and delivery of subunit vaccines. Various antigens have been expressed at sufficiently high levels in plants to render vaccine development practical. An increasing body of evidence demonstrates that these plant-produced antigens can induce immunogenic responses...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2.6.763
更新日期:2003-12-01 00:00:00
abstract::The 11th Annual Conference on Vaccine Research, hosted by the National Foundation for Infectious Disease, attracted approximately 450 leaders in the fields of epidemiology, health economics, immunology and vaccinology, making it the largest scientific meeting devoted exclusively to vaccine research and technology. The...
journal_title:Expert review of vaccines
pub_type:
doi:10.1586/14760584.7.6.721
更新日期:2008-08-01 00:00:00
abstract::Vaccine distribution and delivery has become an issue of significant interest, given the threat of a pandemic influenza outbreak and the resulting need for coordinated efforts to distribute and deliver pandemic influenza vaccines into the hands of healthcare workers responsible for administering them. This review prov...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.6.981
更新日期:2007-12-01 00:00:00