New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.

Abstract:

:Antineutrophil cytoplasmic autoantibodies (ANCA) directed to proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are closely associated with the idiopathic systemic necrotizing vasculitides, in particular Wegener's granulomatosis, microscopic polyangiitis and its renal limited manifestation, and Churg Strauss Syndrome. Many in vitro studies show that those ANCA have phlogistic potential, particularly at the interface of neutrophils and endothelial cells. A limited number of studies in experimental animals support their pathogenetic role. However, ANCA alone are not sufficient, as based on clinical and experimental data, and other, probably exogenous factors, seem necessary for disease induction and (re)activation. Among those silica and particularly, the carriage of Staphylococcus aureus have been proposed. Besides, various genetic factors are involved in disease susceptibility. The ANCA-associated vasculitides are systemic autoimmune diseases in which the interplay of autoimmunity with environmental and genetic factors determines their clinical expression.

journal_name

Autoimmun Rev

journal_title

Autoimmunity reviews

authors

Kallenberg CG,Rarok A,Stegeman CA,Limburg PC

doi

10.1016/s1568-9972(01)00008-8

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

61-6

issue

1-2

eissn

1568-9972

issn

1873-0183

pii

S1568997201000088

journal_volume

1

pub_type

杂志文章,评审
  • The role of nailfold capillaroscopy in the assessment of internal organ involvement in systemic sclerosis: A critical review.

    abstract::Endothelial dysfunction and microvascular damage constitute the hallmarks of systemic sclerosis (SSc), explaining much of the pathophysiology and clinical manifestations of the disease. Nailfold videocapillaroscopy (NVC) is an established method for the assessment of the microvasculature, aiding in distinguishing diff...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2017.05.019

    authors: Soulaidopoulos S,Triantafyllidou E,Garyfallos A,Kitas GD,Dimitroulas T

    更新日期:2017-08-01 00:00:00

  • Novel image processing techniques to better understand white matter disruption in multiple sclerosis.

    abstract::In Multiple Sclerosis (MS) patients, conventional magnetic resonance imaging (MRI) shows a pattern of white matter (WM) disruption but may also overlook some WM damage. Diffusion tensor MRI (DT-MRI) can provide important in-vivo information about fiber direction that is not provided by conventional MRI. The geometry o...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2006.06.003

    authors: Goldberg-Zimring D,Warfield SK

    更新日期:2006-10-01 00:00:00

  • Neonatal lupus: Follow-up in infants with anti-SSA/Ro antibodies and review of the literature.

    abstract::Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clini...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2017.02.010

    authors: Zuppa AA,Riccardi R,Frezza S,Gallini F,Luciano RM,Alighieri G,Romagnoli C,De Carolis S

    更新日期:2017-04-01 00:00:00

  • Use of rituximab in patients with systemic lupus erythematosus: an update.

    abstract::Systemic lupus erythematosus (SLE) is a chronic, occasionally life threatening, multisystem disorder. Patients suffer from a wide group of symptoms and have a variable prognosis that depends of the severity and type of organ involvement. The clinical manifestations include fever, skin lesions, arthritis, neurologic, r...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2008.11.006

    authors: García-Carrasco M,Jiménez-Hernández M,Escárcega RO,Mendoza-Pinto C,Galarza-Maldonado C,Sandoval-Cruz M,Zamudio-Huerta L,López-Colombo A,Cervera R

    更新日期:2009-02-01 00:00:00

  • "How I treat" autoimmune diseases: State of the art on the management of rare rheumatic diseases and ANCA-associated systemic idiopathic vasculitis.

    abstract::This Special Issue of Autoimmunity Reviews constitutes summaries of presentations at the 20th International Meeting on Immunopathology and Orphan Diseases, held in Torino, Italy, 25-28th January 2017. As such, these presentations represent the state of the art on the pathophysiology of autoimmune diseases as well as t...

    journal_title:Autoimmunity reviews

    pub_type: 社论

    doi:10.1016/j.autrev.2017.07.015

    authors: Roccatello D

    更新日期:2017-10-01 00:00:00

  • Enteropathic spondyloarthritis: Results from a large nationwide database analysis.

    abstract:INTRODUCTION:Spondyloarthrits (SpA) share clinical, genetic and immunological features with Inflammatory Bowel Diseases (IBD), and enteropathic SpA (eSpA) represent the clinical evidence of the association between gut and joint diseases. This cross-sectional study aimed to report data of eSpA patients collected from th...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2019.102457

    authors: Picchianti-Diamanti A,Lorenzetti R,Chimenti MS,Luchetti MM,Conigliaro P,Canofari C,Benfaremo D,Bruzzese V,Laganà B,Perricone R,SIGR.

    更新日期:2020-02-01 00:00:00

  • Menopause in patients with autoimmune diseases.

    abstract::Menopause represents a time of significant clinical and hormonal change. Given the incompletely understood interrelationship between gonadal hormones and the immune system, it is possible that menopause may affect, or be affected by, the presence of autoimmune disease. Menopause has significant effects on a number of ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2011.11.006

    authors: Sammaritano LR

    更新日期:2012-05-01 00:00:00

  • Efficacy and safety of rituximab in systemic sclerosis: French retrospective study and literature review.

    abstract:OBJECTIVE:To describe safety and efficacy of rituximab in patients with systemic sclerosis. METHODS:We included 13 patients with systemic sclerosis treated with rituximab and pooled with 40 additional patients from the literature. SSc rituximab untreated patients were matched to rituximab treated ones. RESULTS:Thirte...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.autrev.2017.12.010

    authors: Thiebaut M,Launay D,Rivière S,Mahévas T,Bellakhal S,Hachulla E,Fain O,Mekinian A

    更新日期:2018-06-01 00:00:00

  • CD20: a target antigen for immunotherapy of autoimmune diseases.

    abstract::This article reviews the role of CD20 antigen in B cell function and the effectiveness and limits of passive immunotherapy with anti-CD20 monoclonal antibody (Rituximab) in the treatment of autoimmune (or immune-mediated) diseases. Active immunotherapy is a more feasible way to control these chronic diseases. A peptid...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2005.04.004

    authors: Perosa F,Favoino E,Caragnano MA,Prete M,Dammacco F

    更新日期:2005-11-01 00:00:00

  • Posterior reversible encephalopathy syndrome--Insight into pathogenesis, clinical variants and treatment approaches.

    abstract::Posterior reversible encephalopathy syndrome is a rare clinicoradiological entity characterized by typical MRI findings located in the occipital and parietal lobes, caused by subcortical vasogenic edema. It was first described as a distinctive syndrome by Hinchey in 1996. Etiopathogenesis is not clear, although it is ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2015.05.006

    authors: Granata G,Greco A,Iannella G,Granata M,Manno A,Savastano E,Magliulo G

    更新日期:2015-09-01 00:00:00

  • The birthday of a new syndrome: IgG4-related diseases constitute a clinical entity.

    abstract::IgG4-related disease is a distinct clinical entity, whose characteristic features are the following; Serum IgG4 is prominently elevated, IgG4-positive plasma cells infiltrate in involved tissues, various mass-forming lesions with fibrosis develop in a timely and spatial manner and the response to corticosteroids is pr...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2010.05.003

    authors: Takahashi H,Yamamoto M,Suzuki C,Naishiro Y,Shinomura Y,Imai K

    更新日期:2010-07-01 00:00:00

  • Modulation of autoimmunity with artificial peptides.

    abstract::The loss of immune tolerance to self antigens leads to the development of autoimmune responses. Since self antigens are often multiple and/or their sequences may be known, one approach to restore immune tolerance uses synthetic artificial peptides that interfere or compete with self peptides in the networks of cellula...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2010.08.017

    authors: La Cava A

    更新日期:2010-11-01 00:00:00

  • Coeliac disease.

    abstract::Coeliac disease is a gluten-sensitive enteropathy characterized by villous atrophy, hyperplastic crypts and increased numbers of intraepithelial lymphocytes which are reversed by gluten withdrawal. Diverse autoimmune disorders are frequently associated with the disease, and patients also carry an increased risk of gas...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2005.06.013

    authors: Periolo N,Cherñavsky AC

    更新日期:2006-03-01 00:00:00

  • Polymerase-1 pathway activation in acute multiple sclerosis relapse.

    abstract:BACKGROUND:Increased expression of RNA polymerase 1 (POL1) molecular pathway was reported to be associated with increased disease activity in patients with multiple sclerosis (MS). However, the operating molecular mechanisms that characterize the pattern of acute MS relapse activity has not been thoroughly studied. OB...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2018.07.006

    authors: Achiron A,Zilkha-Falb R,Feldman A,Bovim M,Rozen O,Sarova-Pinhas I,Magalashvili D,Dolev M,Menascu S,Gurevich M

    更新日期:2018-12-01 00:00:00

  • Interaction of pregnancy and autoimmune rheumatic disease.

    abstract::During pregnancy, the fetus represents a natural allograft that is not normally rejected. While the maternal immune system retains the ability to respond to foreign antigens, tolerance mechanisms are up-regulated to protect the fetus from immunologic attacks by the mother. The profound immunologic adaptations during a...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2011.11.013

    authors: Østensen M,Villiger PM,Förger F

    更新日期:2012-05-01 00:00:00

  • The role of stress in the mosaic of autoimmunity: An overlooked association.

    abstract::Stress is defined as the pscyophysiological reaction in which the steady state is disturbed or threatened. Stress is not always perceived as a negative response. Stress results when environmental demands exceed an individuals' adaptive capacities. Autoimmune diseases are heterogeneous group of chronic diseases which o...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2018.04.005

    authors: Sharif K,Watad A,Coplan L,Lichtbroun B,Krosser A,Lichtbroun M,Bragazzi NL,Amital H,Afek A,Shoenfeld Y

    更新日期:2018-10-01 00:00:00

  • Epidemiological and ethical aspects of multiplex autoantibody testing.

    abstract::Arrays are one of the technologies able to detect autoantibodies by measuring simultaneously many thousands of markers from a unique biological sample. The main purpose of a diagnostic test is making an early and accurate diagnosis. From a statistical point of view, multiple testing increases the probability of false ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2007.01.008

    authors: Bidoli E,Villalta D,Ethical Committee of Pordenone Hospital, Italy.,Battistin M,Bidoli E,Cammarota A,Ciccone M,Fedato R,Lodi B,Marchesini F,Molaro G,Ostardo E,Rellini G,Sartori R,Schinella D

    更新日期:2007-06-01 00:00:00

  • The complex immunogenetic basis of systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology with a complex genetic basis that includes many susceptibility genes on multiple chromosomes. As complex human diseases like SLE involve multiple, interacting genetic and environmental determinants, identifying genes for complex tr...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2008.01.001

    authors: Castro J,Balada E,Ordi-Ros J,Vilardell-Tarrés M

    更新日期:2008-05-01 00:00:00

  • Anti-annexin V antibodies: are they prothrombotic?

    abstract::Annexin V inhibits prothrombin activation and is able to prevent thrombus formation under normal venous and arterial blood flow conditions. Antibodies to annexin V have been identified in association with several pathological conditions, including systemic lupus erythematosus (SLE) with or without anti-phospholipid sy...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2004.07.006

    authors: Esposito G,Tamby MC,Chanseaud Y,Servettaz A,Guillevin L,Mouthon L

    更新日期:2005-01-01 00:00:00

  • The dual nature of Ets-1: focus to the pathogenesis of systemic lupus erythematosus.

    abstract::E26 transformation-specific-1 (Ets-1) belongs to the Ets family of transcription factors which share a common 85-amino-acid DNA-binding domain. Ets-1 is essential to regulation of the immune system including immune cell proliferation and differentiation. Past data demonstrated Ets-1 play a role in negative regulation ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2011.01.007

    authors: Leng RX,Pan HF,Chen GM,Feng CC,Fan YG,Ye DQ,Li XP

    更新日期:2011-06-01 00:00:00

  • The geoepidemiology of autoimmune intestinal diseases.

    abstract::Inflammatory bowel diseases (IBD) are chronic diseases of the intestinal tract which principally are composed of ulcerative colitis (UC) and Crohn's disease (CD). The prevalence and incidence of both forms of IBD have historically been higher in developed countries with decreasing North-South gradient. However, more r...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2009.11.008

    authors: Logan I,Bowlus CL

    更新日期:2010-03-01 00:00:00

  • Challenges of automated screening and differentiation of non-organ specific autoantibodies on HEp-2 cells.

    abstract::Analysis of autoantibodies (AAB) by indirect immunofluorescence (IIF) remains the hallmark of diagnosing autoimmune diseases despite the introduction of multiplex techniques. Non-organ specific AAB are screened in routine diagnostics by IIF on HEp-2 cells. However, IIF results vary due to objective (e.g., cell fixatio...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2009.02.033

    authors: Hiemann R,Büttner T,Krieger T,Roggenbuck D,Sack U,Conrad K

    更新日期:2009-09-01 00:00:00

  • A comprehensive analysis of treatment outcomes in patients with pemphigus vulgaris treated with rituximab.

    abstract::Approximately 500 treatment recalcitrant pemphigus vulgaris patients have been treated with rituximab. They were treated according to the lymphoma protocol (N=224) or rheumatoid arthritis protocol (RAP) (N=209) patients. Others were treated with modifications or combinations of the two. The mean duration of follow-up ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2014.12.002

    authors: Ahmed AR,Shetty S

    更新日期:2015-04-01 00:00:00

  • The changing faces of IgG4-related disease: Clinical manifestations and pathogenesis.

    abstract::Since the earliest reports in 2001, immunoglobulin G4 (IgG4)-related disease has been defined as an autoimmune systemic disease characterized by the lymphoplasmacytic infiltration of affected tissues leading to fibrosis and obliterative phlebitis along with elevated serum IgG4 levels. Prior to this unifying hypothesis...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2015.06.003

    authors: Islam AD,Selmi C,Datta-Mitra A,Sonu R,Chen M,Gershwin ME,Raychaudhuri SP

    更新日期:2015-10-01 00:00:00

  • Multimodality imaging and the emerging role of cardiac magnetic resonance in autoimmune myocarditis.

    abstract::Autoimmune responses and inflammation are involved in the excess cardiovascular risk observed in patients with systemic inflammatory diseases. Autoimmune myocarditis is a presentation of an inflammatory reaction of the heart during the course of autoimmune disorders, with most cases seen in systemic lupus erythematosu...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2012.05.005

    authors: Mavrogeni S,Dimitroulas T,Kitas GD

    更新日期:2012-12-01 00:00:00

  • Adrenal insufficiency in systematic lupus erythematosus (SLE) and antiphospholipid syndrome (APS): A systematic review.

    abstract:BACKGROUND:Adrenal insufficiency (AI) is associated with high morbidity and mortality. The aim of this systematic review was to enhance diagnostic approaches and summarize therapeutic strategies in the management of AI in patients with systematic lupus erythematosus (SLE) or antiphospholipid syndrome (APS). METHODS:A ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2018.06.014

    authors: Lee KH,Lee H,Lee CH,Kim JY,Kim JM,Kim SS,Jeong S,Hwang IS,Kim N,Kim NE,Shin S,Shin D,Song JS,Shin DH,Kim JD,Kim J,Lee YS,Kang H,Kim DH,Moon SH,Rho WS,Lee JY,Kronbichler A,Shin JI

    更新日期:2019-01-01 00:00:00

  • Interaction of giant phospholipid vesicles containing cardiolipin and cholesterol with beta2-glycoprotein-I and anti-beta2-glycoprotein-I antibodies.

    abstract::Antiphospholipid syndrome is characterized with thrombotic events and/or pregnancy morbidity and antiphospholipid antibodies (aPL). The most common antigen for aPL is beta2-glycoprotein-I (beta(2)GPI), a plasma protein binding to negatively charged phospholipids. The influence of aPL on coagulation is not well underst...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2006.03.001

    authors: Ambrozic A,Cucnik S,Tomsic N,Urbanija J,Lokar M,Babnik B,Rozman B,Iglic A,Kralj-Iglic V

    更新日期:2006-11-01 00:00:00

  • Gene therapy in autoimmune diseases: challenges and opportunities.

    abstract::Clinical treatment of autoimmune disorders presents a special challenge. For decades, most clinical regimens in autoimmunity has been largely symptomatic and non-disease specific. Although data from vigorous research has lead to accumulating knowledge on the pathogenic and immunological mechanisms of many autoimmune d...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2009.10.004

    authors: Leung PS,Dhirapong A,Wu PY,Tao MH

    更新日期:2010-01-01 00:00:00

  • The clinical presentation and therapy of diseases related to anti-neutrophil cytoplasmic antibodies (ANCA).

    abstract::Anti-neutrophil cytoplasmic antibodies (ANCA) are a family of autoantibodies that react with proteins predominantly expressed in cytoplasmic granules of polymorphonuclear neutrophil granulocytes (PMNs). ANCA was initially detected using indirect immunofluorescence, allowing for different patterns such as p-ANCA (perin...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2016.07.016

    authors: Weiner M,Segelmark M

    更新日期:2016-10-01 00:00:00

  • Complex regional pain syndrome: a comprehensive and critical review.

    abstract::Complex regional pain syndrome (CRPS) is a term used to describe a variety of disorders characterized by spontaneous or stimulus-induced pain that is disproportional to the inciting event and accompanied by a myriad of autonomic and motor disturbances in highly variable combinations. There are no standards which can b...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2013.10.006

    authors: Borchers AT,Gershwin ME

    更新日期:2014-03-01 00:00:00