Abstract:
:Antineutrophil cytoplasmic autoantibodies (ANCA) directed to proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are closely associated with the idiopathic systemic necrotizing vasculitides, in particular Wegener's granulomatosis, microscopic polyangiitis and its renal limited manifestation, and Churg Strauss Syndrome. Many in vitro studies show that those ANCA have phlogistic potential, particularly at the interface of neutrophils and endothelial cells. A limited number of studies in experimental animals support their pathogenetic role. However, ANCA alone are not sufficient, as based on clinical and experimental data, and other, probably exogenous factors, seem necessary for disease induction and (re)activation. Among those silica and particularly, the carriage of Staphylococcus aureus have been proposed. Besides, various genetic factors are involved in disease susceptibility. The ANCA-associated vasculitides are systemic autoimmune diseases in which the interplay of autoimmunity with environmental and genetic factors determines their clinical expression.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Kallenberg CG,Rarok A,Stegeman CA,Limburg PCdoi
10.1016/s1568-9972(01)00008-8keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
61-6issue
1-2eissn
1568-9972issn
1873-0183pii
S1568997201000088journal_volume
1pub_type
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