Familial gliomas. Analysis of six families with cerebral gliomas and without other inheritable syndromes.

Abstract:

:Although a familial tendency to develop brain tumors in the absence of well-recognized hereditary disorders is an important issue, it has been rarely reported. Studies of the familial occurrence of gliomas have yielded conflicting results. This phenomenon may be imputable to chance or environmental or hereditary factors. Furthermore, epidemiological and genetic investigations are fundamental to evidence of whether hereditary factors are active in the development of these tumors. We describe a group of six families, in each of which more than one member had glioma, and discuss the probable mechanisms of oncogenesis in familial tumors in light of the pertinent literature.

journal_name

Neurosurg Rev

journal_title

Neurosurgical review

authors

Caroli E,Salvati M,Peruzzi P,Frati A,Giangaspero F

doi

10.1007/s10143-003-0281-x

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

280-2

issue

4

eissn

0344-5607

issn

1437-2320

journal_volume

26

pub_type

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