Resuscitation of asphyxiated newborns with room air or 100% oxygen at birth: a multicentric clinical trial.

Abstract:

OBJECTIVE:To compare the short-term efficacy of room air versus 100% oxygen for resuscitation of asphyxic newborns at birth. DESIGN:Multicentric quasi randomized controlled trial. SETTING:Teaching hospitals. INCLUSION CRITERIA:Asphyxiated babies weighing greater than 1000 grams, with heart rate less than 100 per min and/or apnea, unresponsive to nasopharyngeal suction and tactile stimuli and having no lethal abnormalities. INTERVENTION:Asphyxiated neonates born on odd dates were given oxygen and those on even dates room air for resuscitation. OUTCOME MEASURES:Primary: Apgar score at 5 minutes; Secondary: Mortality and Hypoxic ischaemic encephalopathy (HIE) during first 7 days of life. RESULTS:A total of 431 asphyxiated babies, 210 in the room air and 221 in 100% oxygen group were enrolled for the study. Both the groups were comparable for maternal, intrapartum and neonatal characteristics. The heart rates in room air and 100% oxygen groups were comparable at 1 minute (94 bpm and 88 bpm), 5 minutes (131 bpm and 131 bpm) and 10 minutes (135 bpm and 136 bpm). Median apgar scores at 5 min [7 versus 7] and 10 minutes [8 versus 8 ], in the room air and oxygen groups respectively, were found to be comparable. Median time to first breath (1.5 versus 1.5 minutes) was similar in the room air and oxygen group. Median time to first cry (2.0 versus 3.0 minutes) and median duration of resuscitation (2.0 versus 3 minutes) were significantly shorter in the room air group. The number of babies with HIE during first seven days of life in the two treatment groups (35.7% babies in room air and 37.1% in the 100% oxygen group) were similar. There was also no statistically significant difference in the overall and asphyxia related mortality in the two treatment groups (12.4% and 10.0% in room air versus 18.1% and 13.6% in oxygen group). CONCLUSION:Room air appears as good as 100% oxygen for resuscitation of asphyxic newborn babies at birth.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Ramji S,Rasaily R,Mishra PK,Narang A,Jayam S,Kapoor AN,Kambo I,Mathur A,Saxena BN

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

510-7

issue

6

eissn

0019-6061

issn

0974-7559

journal_volume

40

pub_type

临床试验,杂志文章,多中心研究
  • Insulin resistance and beta cell function in chronically transfused patients of thalassemia major.

    abstract:OBJECTIVE:To assess the glycometabolic function in chronically transfused patients of beta- thalassemia major in terms of glucose tolerance, insulin secretion, insulin resistance index, and beta cell function index and to determine their relationship with clinical and biochemical profile. METHODS:30 homozygous thalass...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Suvarna J,Ingle H,Deshmukh CT

    更新日期:2006-05-01 00:00:00

  • Pulmonary sarcoidosis masquerading as tuberculosis.

    abstract::Pulmonary manifestations of sarcoidosis are common and may be initially confused with other common diseases like tuberculosis. We report an 11 yr old girl who presented with chronic cough, low grade fever, recent exposure to tuberculosis and hilar lymphadenopathy. She was provisionally diagnosed as pulmonary tuberculo...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Singh M,Kothur K

    更新日期:2007-08-01 00:00:00

  • Implementation of a Mini-Clinical Evaluation Exercise (Mini-CEX) Program to Assess the Clinical Competence of Postgraduate Trainees in Pediatrics.

    abstract:OBJECTIVE:To implement Mini-CEX, a Workplace-based assessment tool, for formative assessment of clinical skills of final year pediatric post-graduate residents. METHODS:All final-year postgraduate residents at the Department of Pediatrics of a public medical college in India underwent mini-CEX assessment by rotation a...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-017-1089-z

    authors: Khalil S,Aggarwal A,Mishra D

    更新日期:2017-04-15 00:00:00

  • An outbreak of pertussis in Sarli Circle of Kurung-kumey district, Arunachal Pradesh, India.

    abstract::An outbreak of suspected pertussis occurred in Sarli circle of Kurung-kumey district of Arunachal Pradesh in 2007. We investigated this outbreak to confirm the etiology, estimate the magnitude and identify reasons for its occurrence. Twenty-six deaths were reported from the circle. We identified 72 case-patients meeti...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Takum T,Gara D,Tagyung H,Murhekar MV

    更新日期:2009-11-01 00:00:00

  • Salmonella senftenberg outbreak in a neonatal unit.

    abstract::Salmonella senftenberg was isolated from the stools of 35 newborns between June, 1987 and September, 1988. Twenty nine (82.8%) babies were preterms and twenty six (74%) babies were less than 2,000 grams in weight. All of them were symptomatic within 6 days of life, 74.3% (26) within 4 days. All of them had loose stool...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Joseph AT,Rammurty DV,Srivastava L,Gupta R,Mohan M,Anand NK

    更新日期:1990-02-01 00:00:00

  • Determinants of lead level in umbilical cord blood.

    abstract::Lead levels were measured by atomic absorption spectrophotometry in umbilical cord blood samples of 205 consecutively born neonates and venous blood in 62 of the mothers. The mean (+/- SD) cord blood lead level was 4.7 +/- 12.1 microg/dL. In the sub sample of 62 mother-baby pairs, the mean (+/- SD) cord blood lead lev...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Patel AB,Prabhu AS

    更新日期:2009-09-01 00:00:00

  • Hyperinsulinemic Hypoglycemia in Infancy: Current Concepts in Diagnosis and Management.

    abstract:PURPOSE:Molecular basis of various forms of hyperinsulinemic hypoglycemia, involving defects in key genes regulating insulin secretion, are being increasingly reported. However, the management of medically unresponsive hyperinsulinism still remains a challenge as current facilities for genetic diagnosis and appropriate...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s13312-015-0772-1

    authors: Vora S,Chandran S,Rajadurai VS,Hussain K

    更新日期:2015-12-01 00:00:00

  • Adiponectin as a marker of complications in type I diabetes.

    abstract:OBJECTIVE:To evaluate adiponectin levels in children and adolescents with type I diabetes, and their relationship to long term complications. DESIGN:Cross sectional. SETTING:Tertiary referral hospital, Cairo, Egypt. PARTICIPANTS:Thirty children and adolescents with type I diabetes mellitus, classified into complicat...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-012-0041-5

    authors: Habeeb NM,Youssef OI,Saab AA,El Hadidi ES

    更新日期:2012-04-01 00:00:00

  • Encephalopathy in type I hyperlipidemia.

    abstract::Familial chylomicronemia syndrome is a group of rare genetic disorders characterized by deficient activity of an enzyme lipoprotein lipase or apo-protein C-II deficiency. In this paper we present an infant with massive hyperchylomicronemia and severe pancreatitis. Exchange transfusion for controlling hypertriglyceride...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Onal H,Atugluzeybek C,Alhaj S,Altun G

    更新日期:2007-04-01 00:00:00

  • Recurrent abdominal pain in childhood: the functional element.

    abstract::Many children report chronic abdominal pain that is severe and disruptive to normal lifestyle and schooling. Assessment and management depends on indentifying those with underlying organic disease, such as chronic infection, celiac disease or inflammatory bowel disease, but avoiding unnecessary invasive investigations...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Bremner AR,Sandhu BK

    更新日期:2009-05-01 00:00:00

  • Immune thrombocytopenic purpura: historical perspective, current status, recent advances and future directions.

    abstract::Immune thrombocytopenic purpura (ITP) has witnessed many changes and updates over the past decade. The definitions of disease subtypes, course and response to treatment have all been standardized recently. Consequent to the lack of an international consensus management guideline, wide variations exist in treatment pra...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s13312-012-0195-1

    authors: Anoop P

    更新日期:2012-10-01 00:00:00

  • Diagnostic approach to primary immunodeficiency disorders.

    abstract::Primary immunodeficiency disorders (PIDs) are a heterogeneous group of inherited disorders that affect different components of the immune system. There are more than 150 different disorders which have been described till date. Despite major advances in the molecular characterization of PIDs over the last 20 years, man...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s13312-013-0171-4

    authors: Madkaikar M,Mishra A,Ghosh K

    更新日期:2013-06-08 00:00:00

  • 2019 Update on Primary Immunodeficiency Disorders by the International Union of Immunological Societies.

    abstract::International Union of Immunological Societies working group recently updated the human inborn errors of immunity. This classification includes 65 new disorders that have been added since the last classification in 2018. This article highlights the important aspects of new classification for the benefit of general ped...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bargir UA,Madkaikar MR

    更新日期:2020-06-15 00:00:00

  • Guillain-Barre syndrome following dengue fever.

    abstract::Guillain-Barre syndrome is a post infectious polyradiculoneuropathy. It is equally prevalent in both the adult and the pediatric populations. Guillain-Barre syndrome following dengue fever is not a classically described entity and has not been reported in children. ...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sulekha C,Kumar S,Philip J

    更新日期:2004-09-01 00:00:00

  • Assessment of iodine deficiency disorders in district Bharatpur, Rajasthan.

    abstract::Iodine deficiency disorders (IDD) is a public health problem in India. A ban on the sale of uniodised salt for household consumption has been introduced in Rajasthan State since 1992. The present study was conducted in the district of Bharatpur, Rajasthan with the objective to assess the prevalence of iodine disorders...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kapil U,Singh P,Pathak P,Singh C

    更新日期:2003-02-01 00:00:00

  • Epidemiology of Cryptosporidium in Pediatric Diarrheal Illnesses.

    abstract:CONTEXT:Cryptosporidium spp. is a zoonotic infection, now being recognized as a significant cause of diarrhea in both immunocompetent and immunocompromised hosts. However, there still exist significant knowledge gaps in its estimated global burden, epidemiology, diagnosis and management. EVIDENCE ACQUISITION:A semi-sy...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,评审

    doi:10.1007/s13312-017-1093-3

    authors: Dabas A,Shah D,Bhatnagar S,Lodha R

    更新日期:2017-04-15 00:00:00

  • Retinal hemorrhages in newborn.

    abstract::Two hundred and fifty eight newborn babies were studied for the presence of retinal hemorrhages between 1-3 days of birth. The overall incidence of retinal hemorrhages was found to be 18.9%. It was observed that the incidence of retinal hemorrhages was higher in unassisted vaginal deliveries than in assisted births. A...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Govind A,Kumari S,Lath NK

    更新日期:1989-02-01 00:00:00

  • Radiological findings in moyamoya disease.

    abstract::The clinical, angiographic and computed tomographic features in eight children with Moyamoya disease were evaluated. The CT Scan findings were correlated with the angiographic features and the stage of the vascular disease. Stenosis/occlusion of the supraclinoid internal carotid artery (ICA) and the proximal parts of ...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jayakumar PN,Vasudev MK,Srikanth SG

    更新日期:1995-04-01 00:00:00

  • White matter changes in GM1 gangliosidosis.

    abstract:BACKGROUND:GM1 gangliosidosis is a disorder due to GLB1 gene mutation. CASE CHARACTERISTICS:A 4-yr-old boy with neuroregression and optic atrophy with periventricular hyperintensity on magnetic resonance imaging. OUTCOME:Beta galactosidase enzyme activity was low which was confirmed by GLB1 sequencing. MESSAGE:We hi...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-015-0593-2

    authors: Tuteja M,Bidchol AM,Girisha KM,Phadke S

    更新日期:2015-02-01 00:00:00

  • Wolcott-Rallison Syndrome- Endocrinopathy with Recurrent Acute Liver Failure.

    abstract::A 2-yr-old child with early onset diabetes and hypothyroidism, and diagnosed as Wolcott-Rallison Syndrome, developed two episodes of acute liver failure and recovered, but he remains at high risk of developing another episode of acute liver failure. Autoimmune, metabolic or genetic disorders should be evaluated in chi...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Valamparampil JJ,Shanmugam N,Rela M

    更新日期:2019-12-15 00:00:00

  • Decade long unexplained anemia: alert to ANCA associated vasculitis.

    abstract::A 13-year old girl presented with a decade long anemia, diffuse alveolar hemorrhage and interstistial lung disease; was eventually diagnosed as ANCA associated vasculitis. High index of suspicion is thus warranted for alternative diagnosis in chronic anemia, despite increased prevalence of infectious diseases and nutr...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-013-0042-z

    authors: Mahajan V,Jat K,Kochhar S,D'Cruz S

    更新日期:2013-02-01 00:00:00

  • Comparative effectiveness of tepid sponging and antipyretic drug versus only antipyretic drug in the management of fever among children: a randomized controlled trial.

    abstract:OBJECTIVE:To compare the effectiveness of tepid sponging and antipyretic drug versus only antipyretic drug among febrile children. DESIGN:Randomized controlled trial. SETTING:Tertiary care hospital. PARTICIPANTS:150 children 6 mo - 12 yr age with axillary temperature 101F. INTERVENTION:Tepid sponging and antipyreti...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Thomas S,Vijaykumar C,Naik R,Moses PD,Antonisamy B

    更新日期:2009-02-01 00:00:00

  • Cranial ultrasonic assessment of infants with acute bacterial meningitis.

    abstract::A prospective study was performed on 44 patients (newborn to one year old) with acute bacterial meningitis. Sonograms were obtained within 72 hours of diagnosis, and repeated on 7th, 14th or at an early date, if required. The spectrum of sonographic features of meningitis included normal scan (35.4%), echogenic sulci ...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Soni JP,Gupta BD,Soni M,Gupta M,Dabi DR,Nemal KR

    更新日期:1994-11-01 00:00:00

  • Trichotillomania.

    abstract::Trichotillomania, though uncommon, is one of the causes of unexplained hair loss, especially in children. Three girls in the age group of 4-6 years were observed in our pediatric dermatology clinic to have trichotillomania. In one child, there was co-existent alopecia areata. All were referred to the child guidance cl...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bhalla M,Sarkar R,Arun P,Kanwar AJ

    更新日期:2003-01-01 00:00:00

  • Mass Administration of Azithromycin to Prevent Pre-school Childhood Mortality: Boon or Bane?: Evidence-based Medicine Viewpoint.

    abstract:: ...

    journal_title:Indian pediatrics

    pub_type: 评论,杂志文章

    doi:

    authors: Mathew JL

    更新日期:2019-09-15 00:00:00

  • Furazolidone in typhoid fever--correlation of clinical efficacy with serum bactericidal activity.

    abstract::Treatment of typhoid fever with furazolidone produces a high cure rate. This is a clinical curiosity, as furazolidone is described to be poorly absorbed. The present study examined whether furazolidone could produce unequivocal clinical response and, if so whether this was due to the drug producing bactericidal levels...

    journal_title:Indian pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kumar AS,Legori M,Sathy N,Mathew R

    更新日期:1995-05-01 00:00:00

  • Mucoepidermoid Carcinoma of Parotid as a Second Malignancy in Acute Lymphoblastic Leukemia.

    abstract:BACKGROUND:Improved survival seen in Acute Lymphoblastic Leukemia (ALL) cases has led to increased reports of second malignant neoplasms. CASE CHARACTERISTICS:A 12-year-old female treated for ALL using UK ALL XI protocol nine years back presented with progressively increasing pre-auricular swelling. OBSERVATION:Inves...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-015-0757-0

    authors: Tikku G,Jain D,Kumari A,Grover R

    更新日期:2015-11-01 00:00:00

  • Maternal weight, height and risk of poor pregnancy outcome in Ahmedabad, India.

    abstract::This paper explores the relationships between maternal weight, height and poor pregnancy outcome using a data set from a case-control study of low birth weight (LBW) and perinatal mortality in Ahmedabad, India. Maternal height and weights were compared between mothers of 611 perinatal deaths, 644 preterm-LBW, and 1465...

    journal_title:Indian pediatrics

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Mavalankar DV,Trivedi CC,Gray RH

    更新日期:1994-10-01 00:00:00

  • Effectiveness of a community oral health awareness program.

    abstract:OBJECTIVE:To evaluate the effectiveness of a community oral health awareness program given to mothers through trained community level workers (Junior Public Health Nurses (JPHNs) and Anganwadi workers (AWWs). METHODS:Oral health education materials were prepared based on the findings of a knowledge survey among commun...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:

    authors: Nair MK,Renjit M,Siju KE,Leena ML,George B,Kumar GS

    更新日期:2009-01-01 00:00:00

  • Biliary atresia and cytomegalovirus and response to valganciclovir.

    abstract::Biliary atresia has been commonly reported with cytomegalovirus (CMV) infection. CMV positive patients may present with a later onset however long term outcome is similar to non-CMV patients. There are very few case reports of role of antivirals in CMV and biliary atresia. We treated a 2 month old girl with biliary at...

    journal_title:Indian pediatrics

    pub_type: 杂志文章

    doi:10.1007/s13312-012-0092-7

    authors: Shah I,Bhatnagar S

    更新日期:2012-06-01 00:00:00