The ATPases: a new family for a family-based drug design approach.

abstract：INTRODUCTION:Syndecans are cell surface adhesion receptors that play important functional roles. Their deregulation has been linked to several pathologies, and their aberrant regulation via diverse mechanisms is critically involved in the pathogenesis of various cancers. Similar to other receptors, syndecan functions a...

journal_title：Expert opinion on therapeutic targets

authors： Choi S,Kang DH,Oh ES

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To compare the distribution of pro-inflammatory cytokines in heart valve lesions with their plasma levels. METHODS:Plasma levels of TNF-alpha and IL-10 were determined in 70 patients with heart valve lesions. TNF-alpha and IL-6 levels were also quantified in tissue specimens obtained from these patients afte...

journal_title：Expert opinion on therapeutic targets

authors： Toli K,Paraskevas KI,Poulakou MV,Agrogiannis G,Kavantzas N,Xanthopoulos V,Iliopoulos DG,Mantas I,Papachristodoulou A,Patsouris E,Mikhailidis DP,Perrea DN

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Epigenetic mechanisms of gene regulatory control play fundamental roles in developmental morphogenesis, and, as more recently appreciated, are heavily implicated in the onset and progression of neoplastic disease, including cancer. Many epigenetic mechanisms are therapeutically targetable, providing additi...

journal_title：Expert opinion on therapeutic targets

authors： McCann TS,Sobral LM,Self C,Hsieh J,Sechler M,Jedlicka P

更新日期：2019-04-01 00:00:00

abstract：:Great inroads have been made in defining the oncogenic pathways intrinsic to neoplastic cells and the mechanisms by which they are activated in tumors. Knowledge of these pathways provides numerous opportunities that are actively being pursued to develop targeted therapies for cancer. Complementary studies, focused on...

journal_title：Expert opinion on therapeutic targets

authors： Puré E

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory disorder of the peripheral nervous system (PNS). Experimental autoimmune neuritis (EAN) is a useful animal model for studying GBS. Currently, GBS remains a life-threatening disorder and more effective therapeutic strategies are in urgent need...

journal_title：Expert opinion on therapeutic targets

authors： Wu X,Wang J,Liu K,Zhu J,Zhang HL

更新日期：2016-01-01 00:00:00

abstract：:The past decade has witnessed a rapid expansion of our understanding of the biological roles of cannabinoids and their cognate receptors. It is now certain that Delta9-tetrahydrocannabinol, the principle psychoactive component of the Cannabis sativa plant, binds and activates membrane receptors of the 7-transmembrane ...

journal_title：Expert opinion on therapeutic targets

authors： Jones S,Howl J

更新日期：2003-12-01 00:00:00

abstract：:Recent evidence has demonstrated the existence of a small subset of the tumour mass that is wholly responsible for the sustained growth and propagation of the tumour. This cancer stem cell (CSC) compartment is also likely to be responsible both for disease relapse and the resistance to therapy that often accompanies r...

journal_title：Expert opinion on therapeutic targets

authors： Kvinlaug BT,Huntly BJ

更新日期：2007-07-01 00:00:00

abstract：INTRODUCTION:The onset of puberty in females is highly sensitive to the nutritional status and the amount of energy reserves of the organism. This metabolic information is sensed and transmitted to hypothalamic GnRH neurons, considered to be ultimately responsible for triggering puberty through the coordinated action o...

journal_title：Expert opinion on therapeutic targets

authors： Castellano JM,Tena-Sempere M

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Since its discovery nearly 20 years ago, the Ron receptor tyrosine kinase has been extensively studied. These studies have elucidated many of the major signaling pathways activated by Ron. In the context of the inflammation and cancer, studies have shown that Ron plays differential roles; Ron activation li...

journal_title：Expert opinion on therapeutic targets

authors： Benight NM,Waltz SE

更新日期：2012-09-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Fas receptor is a mediator of the external apoptotic pathway in many cells and tissues. It is proposed that Fas receptor mediates osteoresorptive effects of estrogen deficiency and local/systemic inflammation. AREAS COVERED IN THIS REVIEW:This review covers the past two decades of research on t...

journal_title：Expert opinion on therapeutic targets

authors： Kovacic N,Grcevic D,Katavic V,Lukic IK,Marusic A

更新日期：2010-10-01 00:00:00

abstract：:Genomics has changed our view of the biological world in the past decade, providing both new information and new tools to characterise biological systems. Over 100 microbial genomes - including many of substantial clinical importance - have been fully or partially sequenced, pushing the search for novel antimicrobial ...

journal_title：Expert opinion on therapeutic targets

authors： Schmid MB

更新日期：2001-08-01 00:00:00

abstract：:Cortistatin (CST) is a recently discovered neuropeptide from the somatostatin gene family, named after its predominantly cortical expression and ability to depress cortical activity. CST shows many remarkable structural and functional similarities to its related neuropeptide somatostatin, or somatotropin release-inhib...

journal_title：Expert opinion on therapeutic targets

authors： Rubio A,Avila J,de Lecea L

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Efficacious chemotherapy does not exist for treatment or prevention of prostate, liver, and pancreatic carcinomas, and some other cancers that exhibit decreased zinc in malignancy. Zinc treatment offers a potential solution; but its support has been deterred by adverse bias. Areas covered: 1. The clinical ...

journal_title：Expert opinion on therapeutic targets

authors： Costello LC,Franklin RB

更新日期：2017-01-01 00:00:00

abstract：:IL-19 and IL-20 are two cytokines that were discovered in 2000 and 2001, respectively. Based on the structure and location of their genes, their primary and secondary protein structures and the used receptor complexes, they were classified with IL-10, IL-22, IL-24, IL-26, IL-28 and IL-29 in the IL-10 family of cytokin...

journal_title：Expert opinion on therapeutic targets

authors： Sabat R,Wallace E,Endesfelder S,Wolk K

更新日期：2007-05-01 00:00:00

abstract：:NF-kappaB transcription factors and the signaling pathways that activate them play a critical role in cancer development, progression and therapy, and recently have become a focal point for intense drug discovery and development efforts. This article presents a critical review on the different types of inhibitors targ...

journal_title：Expert opinion on therapeutic targets

authors： Melisi D,Chiao PJ

更新日期：2007-02-01 00:00:00

abstract：:Metastases are responsible for most cancer deaths. Despite dramatic advances in cancer therapy, the presence of metastases implies a significantly shortened survival and reduced quality of remaining life. Aside from prevention of cancer altogether, or significant improvements in early detection for most cancers, effec...

journal_title：Expert opinion on therapeutic targets

authors： Hedley BD,Winquist E,Chambers AF

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:Tumor-associated angiogenesis is one of the essential hallmarks underlying cancer development and metastasis. Anti-angiogenic agents accordingly aim to restrain cancer progression by blocking the formation of new vessels, improving the delivery of chemotherapeutic agents to the tumor site and reducing the ...

journal_title：Expert opinion on therapeutic targets

authors： Johannessen TC,Wagner M,Straume O,Bjerkvig R,Eikesdal HP

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:There is a need to develop new bone anabolic agents because current bone regeneration regimens have limitations. The Wingless-type MMTV integration site (Wnt) pathway has emerged as a regulator of bone formation and regeneration. OBJECTIVE:To review the molecular basis for Wnt pathway modulation and discuss...

journal_title：Expert opinion on therapeutic targets

authors： Hoeppner LH,Secreto FJ,Westendorf JJ

更新日期：2009-04-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a pleiomorphic cytokine whose growth factor properties play an important role in the development and progression of many types of cancer. IL-6 is produced in response to a variety of stimuli, and is required for the development of T and B lymphocytes to effector cells. In certain neoplasias, su...

journal_title：Expert opinion on therapeutic targets

authors： Barton BE

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Thyroid hormone (TH) metabolism is mediated by deiodinases, a family of thioredoxin fold-containing enzymes that remove iodide from thyroxine and its derivatives. The coordinated action of deiodinases allows target cells to modulate rapidly their own TH availability in response to different cues. Type 3 de...

journal_title：Expert opinion on therapeutic targets

authors： Dentice M,Antonini D,Salvatore D

更新日期：2013-11-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death in women with gynecological malignancies and overall survival for patients with advanced epithelial ovarian cancer (EOC) remains poor. The majority of patients recur after initial treatment. A strategy for improving outcome is to minimise recurrence via targeted therapy in ...

journal_title：Expert opinion on therapeutic targets

authors： Sharma S,Odunsi K

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Systemic chemotherapy is a curative approach to inhibit gastric cancer cells proliferation. Despite the great progress in anti-cancer treatment achieved during the last decades, drug resistance and treatment refractoriness still extensively persists. Recently, accumulating studies have highlighted the role...

journal_title：Expert opinion on therapeutic targets

authors： Yang W,Ma J,Zhou W,Cao B,Zhou X,Yang Z,Zhang H,Zhao Q,Fan D,Hong L

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Part 1 of this review described the importance of histone acetylases, deacetylases, methylases and demethylases in transcriptional control and their potential as therapeutic targets. However, precise gene regulation requires the involvement of more than just the addition or removal of acetyl and methyl group...

journal_title：Expert opinion on therapeutic targets

authors： Keppler BR,Archer TK

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:The MAPK pathway comprises several key signaling components and phosphorylation events that play a role in tumorigenesis. These activated kinases transmit extracellular signals that regulate cell growth, differentiation, proliferation, apoptosis and migration functions. Alteration of the RAS-RAF-MEK-ERK-MA...

journal_title：Expert opinion on therapeutic targets

authors： Santarpia L,Lippman SM,El-Naggar AK

更新日期：2012-01-01 00:00:00

abstract：:Mechanisms to reduce the deleterious effects of myocardial ischaemia are of particular clinical importance and have been the focus of intense research for a number of years. Among novel approaches to studying the ischaemic heart, proteomics, or the analysis of all cellular proteins, presents as a powerful method to de...

journal_title：Expert opinion on therapeutic targets

authors： Vondriska TM,Ping P

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:The common predominant clinical features of cholangiopathies such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and biliary atresia (BA) are biliary damage/senescence and liver fibrosis. Curative therapies are lacking, and liver transplantation is the only option. An understan...

journal_title：Expert opinion on therapeutic targets

authors： Sato K,Glaser S,Kennedy L,Liangpunsakul S,Meng F,Francis H,Alpini G

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Asparagine endopeptidase (AEP) is a pH-dependent endolysosomal cysteine protease that cleaves its substrates after asparagine residues. Our most recent study identifies that it possesses the delta-secretase activity, and that it is implicated in numerous neurological diseases such as Alzheimer's disease (A...

journal_title：Expert opinion on therapeutic targets

authors： Zhang Z,Xie M,Ye K

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Calreticulin is an endoplasmic reticulum (ER) resident protein critical for maintaining Ca(2+) homeostasis and glycoprotein folding in the ER. The protein has also been identified on the cell surface of apoptotic and necrotic cells and implicated to play a role in immunogenic cell death and other extracell...

journal_title：Expert opinion on therapeutic targets

authors： Eggleton P,Bremer E,Dudek E,Michalak M

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Nuclear factor TDP-43 is a ubiquitously expressed RNA binding protein that plays a key causative role in several neurodegenerative diseases, especially in the ALS/FTD spectrum. In addition, its aberrant aggregation and expression has been recently observed in other type of diseases, such as myopathies and ...

journal_title：Expert opinion on therapeutic targets

authors： Buratti E

更新日期：2018-03-01 00:00:00

abstract：:Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated. Translation from in vitro and in vivo results to the human setting f...

journal_title：Expert opinion on therapeutic targets

authors： Alkema W,Rullmann T,van Elsas A

更新日期：2006-10-01 00:00:00