Abstract:
:This review describes microbial transformation studies of natural drugs, its importance in correlating them with the corresponding metabolism (biotransformation) in animal system and in the structural modification of complex drug molecules, which are difficult to obtain synthetically. Emphasis is laid on the potential microorganisms, which mimic the pathways of mammalian metabolism and which involve in stereoselective, regiospecific and selective conversions of natural drugs to their derivatives by microorganisms, which are more useful and difficult to synthesize. This paper describes the present state-of-art, will elucidate the additional possibilities with microbial biotransformation of natural drugs, i.e., comparison of microbial transformation with mammalian metabolism and possibility of producing novel molecules, which are difficult to produce by other means.
journal_name
Curr Pharm Biotechnoljournal_title
Current pharmaceutical biotechnologyauthors
Venisetty RK,Ciddi Vdoi
10.2174/1389201033489847keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
153-67issue
3eissn
1389-2010issn
1873-4316journal_volume
4pub_type
杂志文章,评审abstract::A variety of technologies can be used in the detection of contagious pathogens. In the early stage of an outbreak of a new infectious disease, rtPCR is advantageous over many other assays. The rtPCR can be developed either using low fidelity DNA polymerase or high fidelity DNA polymerase. The application of high fidel...
journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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更新日期:2001-12-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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更新日期:2015-01-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
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更新日期:2014-01-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
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更新日期:2010-12-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
doi:
更新日期:2013-01-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
doi:10.2174/138920112800958940
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Bacterial lipases especially Pseudomonas lipases are extensively used for different biotechnological applications. OBJECTIVES:With the better understanding and progressive needs for improving its activity in accordance with the growing market demand, we aimed in this study to improve the recombinant product...
journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
abstract:AIMS:The present study aims to determine the antimicrobial efficacy of Alphonsea madraspatana leaves extract against selected uropathogens. BACKGROUND:The plant Alphonsea madraspatana is an endangered species, reported to exhibit high antimicrobial activity due to the presence of phenolic compounds. Prevalence of high...
journal_title:Current pharmaceutical biotechnology
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更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Recently, spinel structures (AB2O4) nanoparticles (NPs) having binary and ternary mixtures of metal oxides were established as promising redox catalysts. Due to the presence of two mixed valence metal cations transport of electrons takes place easily between multiple transition-metal cations with relatively ...
journal_title:Current pharmaceutical biotechnology
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更新日期:2020-11-17 00:00:00
abstract::There is a growing trend of herbal medicines in India as well as other parts of the world. The use of herbal medicines alone or alongside prescription drugs for disease management is quite common now. We hereby carry out a review of dominant species of Selinum mainly S. vaginatum C.B. Clarke and S. wallichianum (DC.) ...
journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract::Assessment of immunogenicity is a major aspect in evaluating the safety of biological therapeutic proteins. It is important to evaluate the immunogenic potential of the biologics in an appropriate fashion using clearly defined strategy and clinical trials. The studies must include the appropriate risk assessment proce...
journal_title:Current pharmaceutical biotechnology
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更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The re-emerging of targeting Dihydroorotate Dehydrogenase (DHODH) in cancer treatment particularly Acute Myelogenous Leukemia (AML) has corroborated the substantial role of DHODH in cancer and received the attention of many pharmaceutical industries. OBJECTIVE:The effects of Brequinar Sodium (BQR) and 4SC-1...
journal_title:Current pharmaceutical biotechnology
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更新日期:2020-01-01 00:00:00