Application of microbial biotransformation for the new drug discovery using natural drugs as substrates.

Abstract:

:This review describes microbial transformation studies of natural drugs, its importance in correlating them with the corresponding metabolism (biotransformation) in animal system and in the structural modification of complex drug molecules, which are difficult to obtain synthetically. Emphasis is laid on the potential microorganisms, which mimic the pathways of mammalian metabolism and which involve in stereoselective, regiospecific and selective conversions of natural drugs to their derivatives by microorganisms, which are more useful and difficult to synthesize. This paper describes the present state-of-art, will elucidate the additional possibilities with microbial biotransformation of natural drugs, i.e., comparison of microbial transformation with mammalian metabolism and possibility of producing novel molecules, which are difficult to produce by other means.

journal_name

Curr Pharm Biotechnol

authors

Venisetty RK,Ciddi V

doi

10.2174/1389201033489847

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

153-67

issue

3

eissn

1389-2010

issn

1873-4316

journal_volume

4

pub_type

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