Abstract:
:The permeation of cyproterone acetate (CPA) from Derma Membrane Structure (DMS) creams and liposomal formulations was investigated. Standard diffusion experiments with dermatomed porcine skin were performed. The cumulative CPA amount permeated of the DMS creams was between 2.9 and 6.8 microg/cm(2) within 48 h. By addition of a phospholipid concentrate, the CPA permeation could be 2.6-fold further increased compared to the control DMS. A working temperature of 60 degrees C resulted in a change of the preparation and a higher permeation which could be confirmed by additional differential scanning calorimetry studies. In case of the liposomal formulations, the CPA permeation was strongly dependent on the lipid content. The higher the lipid content, the higher was the CPA permeation. Extruding procedures for decreasing the particle size of the liposomes resulted in a two-fold increase in CPA permeation compared to the unextruded liposomes. It is possible to control the CPA permeation by combining various formulations containing different phospholipids with saturated and unsaturated fatty acids.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Valenta C,Janisch Mdoi
10.1016/s0378-5173(03)00180-7keywords:
subject
Has Abstractpub_date
2003-06-04 00:00:00pages
133-9issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517303001807journal_volume
258pub_type
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journal_title:International journal of pharmaceutics
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-04-30 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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