Abstract：
OBJECTIVES:Histones are involved in process of proliferation and differentiation of the cells. In many lesions the expression of mRNA of histones is a marker of proliferation. The expression of kinin receptors B1 and B2 coexist with inflammatory processes, but in some studies the expression of these receptors was found to influence the growth and differentiation of different cells. DESIGN:In search of proliferation markers in squamous cell vulvar cancer we have analysed the correlation between the expression of the mRNA of histone H2B and H4 and mRNA of kinin receptors B1 and B2. MATERIALS AND METHODS:The specimen obtained from 46 women operated for squamous cell vulvar cancer stages I to IV according to FIGO were analysed. RNA was extracted and the number of mRNA copies were assessed by QRT-PCR using ABI PRISM 7700 (TaqMan). RESULTS:The results obtained in this study indicate a statistically significant correlation between mRNA B1 and mRNA H4 (p < 0.01), B2 and histone H4 (p < 0.01) B1 and histone H2B (p < 0.01). CONCLUSIONS:The expression of mRNA of histones and kinins receptors may reflects the dynamics of neoplastic growth in vulvar cancer.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Olejek A,Mazurek U,Kuśmierz D,Michalska A,Wilczok Tkeywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
897-903issue
11eissn
0017-0011issn
2543-6767journal_volume
73pub_type
杂志文章abstract：:32 patients with hydatid mole were subjected to serological tests to determine the concentration of chorionic gonadotropin (HCG) in the urine. The patients were divided into 2 groups, depending on the duration of the amenorrhea. Group 1 (20 cases) showed a uterus size not exceeding the volume of the 12th week of ges...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the safety, feasibility, and effectiveness of transvaginal myomectomy surgery. MATERIAL AND METHODS:We conducted a retrospective study in Shengjing Hospital of China Medical University. In all, 138 patients underwent transvaginal myomectomy from March 2009 to March 2019...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2019.0106
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to compare caffeine and paraxanthine concentrations in venous blood of pregnant women and in the umbilical cord blood of their newborns. MATERIALS AND METHODS:Pregnant women who gave birth at the Clinic of Obstetrics, Gynecology and Oncology 2nd Faculty of Medicine, Medical Universit...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1760
更新日期：2014-07-01 00:00:00
abstract：:Matrix metalloproteinases are proteolytic enzymes which degrade extracellular matrix proteins. Along with their specific inhibitors--issue inhibitors of metalloproteinases--they play an important role in the spreading of malignant tumours. The research conducted in recent years has shown that metalloproteinases and th...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Proper age of sexual initiation remains a topical issue in developmental sexology and gynecology Premature sexual début is a risk factor for sexually transmitted diseases (STD) and their consequences: unplanned pregnancy and emotional stress. Consequences of risky sexual behavior (young age of sexual initiat...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：THE AIM OF STUDY:Estimation of Polish population standards of the concentrations of pregnancy-associated plasma protein--A (PAPP-A) and free beta--human chorionic gonadotropin (beta-HCG) in the maternal blood between 10.0 and 13.6 week of pregnancy and comparison of the biochemistry own normal ranges and literature rep...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:We present a case report of a 37-year-old woman with accidental finding of two IUDs--one inserted correctly and the other one located in the abdomen. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:The aim of our study was to compare ultrasound vascular blood flow indices with the expression of CD-34 in women with benign and malignant adnexal tumors. MATERIALS AND METHODS:Transvaginal color and pulsed Doppler sonography was performed before surgical procedure in 105 women with adnexal tumors. Blood flo...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:Venous insufficiency can be defined as a fixed venous outflow disturbance of the limbs. It is caused by the malfunction of the venous system, that may or may not be associated with venous valvular insufficiency and may involve the superficial or deep venous system of the lower limbs, or both. The CEAP scale includes c...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/1540
更新日期：2013-01-01 00:00:00
abstract：:Bladder Pain Syndrome remains a great challenge for urologists, both in diagnostics and treatment. Etiopathogenesis of the disease is unknown. It is reported that the reason for Bladder Pain Syndrome is the urothelium dysfunction resulting in the destruction of the protective glycosaminoglycan layer/barrier protecting...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVES:1) to analyse the prevalence of selected candidate genes for type 2 diabetes mellitus polymorphisms (IRS1 G972R; ENPP1 K121Q; ADRB3 W64R) among women with gestational diabetes; and 2) to investigate any association between variants of these genes and risk of neonatal macrosomia. MATERIAL AND METHODS:We cond...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2018.0119
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to evaluate the concentrations of kynurenic acid (KYNA) in blood and urine during the normal pregnancy. MATERIALS AND METHODS:Under the study were 37 pregnant women. Level of KYNA was measured by high performance liquid chromatography (HPLC). RESULTS:The KYNA concentration in blood...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:We have analysed 6 cases of twin pregnancies with vertex presentation of the first foetus. In this cases after delivery of the first twin by vaginal route caesarean, section was made. Caesarean section of the second twin was made because of: transversal presentation with fetal distress syndrom (four cases), umbilical ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:Two cases of the Meckel-Gruber syndrome were described at two subsequent pregnancies. Suspicion of this syndrome was established by ultrasonography and confirmed by histopathological findings. Both of the pregnancies were terminated by premature induced delivery. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVES:The aim of our study was clinical analysis of patients operated with squamous cell carcinoma of the uterine cervix. MATERIALS AND METHODS:Between 1972 and 1991 at the 2nd Department of Obstetrics and Gynecology Medical University of Gdańsk 687 total hysterectomies in Wertheim-Meigs method were performed in ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:This paper sums up the results of treatment with laparoscopy the patients suffering from infertility of unknown reason. Laparoscopy was performed in 75 patients and only in 21.3% of cases the reason of infertility remained unclear. In most of infertile women (90%) different factors of infertility were revealed--among ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:The group of 277 girls treated for vulvovaginitis was investigated. Any objective and subjective factors, which could effect on occurrence of this disease at girls were analysed. Over 2/3 of investigated girls were before menarche, 36.5% were 3-7 years old. Over 30% had urinary tract infections, 10%--tonsillitis. No e...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Ultrasonic velocimetry of the fetal circulation became a very useful method in assessment of fetal well-being, especially in high risk pregnancies. There are many papers concerning on distribution and regulation of blood flow in umbilical artery, middle cerebral artery, and much less dealing with flow velocity wavefor...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-02-01 00:00:00
abstract：:This study was performed in 52 women in their early postmenopausal period, divided into two equal groups. The control group included women with menopausal symptoms only, women in the study group demonstrated also pruritus. All women were on estrogen replacement therapy, additionally a bacterial auto-vaccine was admini...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVES:Osteoporosis is a multifactoral disease with aetiology depending from the hormonal, environmental, and genetic factors. One of the suggested candidate gene involved in the pathogenesis is the polymorphic gene encoding for vitamin D receptor (VDR). VDR polymorphism was connected with bone mineral density (BMD...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：:The paper presents the course of treatment and results of pathological changes in the uterine cervix in 41 patients who underwent cryotherapy by means of a cryotherapeutic apparatus UK-32, using liquid nitrogen as cryogenic fluid. Complete recovery in the form of typical stratified squamous epithelium was achieved in ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVES:Pregnancy induced hypertension is believed to be a state of neutrophil overactivity, however all previous studies were done on isolated cells. DESIGN:To study neutrophil activity in whole blood of PIH women. MATERIALS AND METHODS:Neutrophil activity was estimated without isolation, in peripheral whole bloo...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVES:Paternal lymphocytes immunization has been proposed for several years as an efficient treatment for unexplained Recurrent Spontaneous Abortion (RSA), however precise mechanism that underline the benefits of this immunotherapy is still unclear. DESIGN:The aim was to study the influence of paternal lymphocyte...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVES:Evaluate the time dependent expression of genes in preterm neonates and verify the influence of ontogenic maturation and the environmental factors on the gene expression after birth. MATERIAL AND METHODS:The study was carried out on 20 full-term newborns and 62 preterm newborns (mean birth weight = 1002 [g]...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2017.0080
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:Cervical cancer is the only gynecological tumor staged clinically. The aim of this study was comparison of clinical staging to surgical specimen evaluation in cervical cancer patients. DESIGN:Clinical staging of cervical cancer was compared to histopathological outcome in prospective study. MATERIALS AND M...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：:The aim of this study was to evaluate the predictive value of respiratory distress syndrome-RDS evidence using amniotic fluid diagnostic tests. 200 amniotic fluid samples obtained by amniocentesis were study to evaluate pulmonary tissue maturity status. The PG test was 30% specific and 100% sensitive; FLM test showed ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:The authors presented the frequency of urinary tract infection (u.t.i) in pregnancy in own practice. Additional complications in pregnancy with asymptomatic bacteriuria and acute pyelonephritis were described. Postnatal period of neonates born from mothers with u.t.i. in pregnancy were analyzed. The authors defined th...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma activities of antithrombin III, protein C and protein S before and after 6 and 12 months of HRT in 48 postmenopausal women. HRT consisted of transdermal estradiol and orally medroxyprogest...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：OBJECTIVE:To investigate long-term postoperative outcomes of conservative and radical surgery in ectopic tubal pregnancies, and evaluate the results of these techniques. METHODS:A total of 145 patients that operated for tubal pregnancy between January 2006 and January 2009 were reviewed. Data on patient age, reproduct...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：:Endometrial cancer is one of the most frequently diagnosed malignant neoplasms among women. In Poland, it is in the fourth place in terms of incidence. The highest morbidity concerns women aged 50-70 years, however it may also appear in women in their reproductive period. Endometrial cancer concerns about 3% of premen...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
