Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition.

abstract：:Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective cancer immunotherapy for tumors that are immune inflamed or induced to become "hot". It has also been demonstrated that a small molecule inhibitor of the signaling hub kinase GSK3 can interfere in the PD-1/PD-L1 axis in T-cells by s...

journal_title：Biomaterials

authors： Allen SD,Liu X,Jiang J,Liao YP,Chang CH,Nel AE,Meng H

更新日期：2020-12-28 00:00:00

abstract：:Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages...

journal_title：Biomaterials

authors： Boon ME,Ruijgrok JM,Vardaxis MJ

更新日期：1995-09-01 00:00:00

abstract：:The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation. However, the exact roles of ameloblast-derived factors in odontoblast differentiation have not yet been characterized. We investigated the effects of preameloblast-conditioned medium (PA-CM) on t...

journal_title：Biomaterials

authors： Lee JH,Lee DS,Choung HW,Shon WJ,Seo BM,Lee EH,Cho JY,Park JC

更新日期：2011-12-01 00:00:00

abstract：:Immobilization of biomolecules on surfaces enables both localization and retention of molecules at the cell-biomaterial interface. Since metallic biomaterials used for orthopedic and dental implants possess a paucity of reactive functional groups, biomolecular modification of these materials is challenging. In the pre...

journal_title：Biomaterials

authors： Puleo DA,Kissling RA,Sheu MS

更新日期：2002-05-01 00:00:00

abstract：:Over the last few decades, colloidal drug delivery systems (CDDS) such as nano-structures have been developed in order to improve the efficiency and the specificity of drug action. Their small size permits them to be injected intravenously in order to reach target tissues. However, it is known that they can be rapidly...

journal_title：Biomaterials

authors： Vonarbourg A,Passirani C,Saulnier P,Benoit JP

更新日期：2006-08-01 00:00:00

abstract：:Photopolymerized hydrogels are being investigated for a number of tissue engineering applications because of the ability to form these materials in situ in a minimally invasive manner such as by injection. In addition, hydrogels, three-dimensional networks of hydrophilic polymers that are able to swell large amounts o...

journal_title：Biomaterials

authors： Nguyen KT,West JL

更新日期：2002-11-01 00:00:00

abstract：:Impurity centers associated with silicon have been observed in the phase mixture of silicon substituted apatite (Si-Ap) and silicon stabilized tricalcium phosphate (Si-TCP) using electron spin resonance (ESR). Two unique centers occur upon addition of SiO2 to the calcium phosphate system: an orthorhombic center with g...

journal_title：Biomaterials

authors： Pietak AM,Reid JW,Sayer M

更新日期：2005-06-01 00:00:00

abstract：:The formation of bone tissue in pores, and around, a block made of partially dehydroxylated porous hydroxyapatite ceramic and implanted into a rat's femur using X-ray diffraction (XRD), infrared spectroscopy (IRS) and histological methods were investigated. Structural characteristics and composition of new bone tissue...

journal_title：Biomaterials

authors： Zyman Z,Ivanov I,Glushko V,Dedukh N,Malyshkina S

更新日期：1998-07-01 00:00:00

abstract：:The adherence of five strains of Staphylococcus epidermidis and one strain of S. aureus to both untreated and Hydromer-coated silicone rubber cerebrospinal fluid shunts was studied in vitro using epifluorescent image analysis. All five strains of S. epidermidis showed similar levels of adherence to untreated shunts, w...

journal_title：Biomaterials

authors： Bridgett MJ,Davies MC,Denyer SP,Eldridge PR

更新日期：1993-02-01 00:00:00

abstract：:Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic infor...

journal_title：Biomaterials

authors： Roussakis E,Ortines RV,Pinsker BL,Mooers CT,Evans CL,Miller LS,Calderón-Colón X

更新日期：2019-08-01 00:00:00

abstract：:Silica nanoparticles (SiO2-NPs) has been extensively exploited in biomedical fields and mostly designed to enter the circulatory system, however, few studies focused on the potential adverse effects of SiO2-NPs exposure on the blood-brain barrier (BBB) that serves as a critical barrier between the central nervous syst...

journal_title：Biomaterials

authors： Liu X,Sui B,Sun J

更新日期：2017-03-01 00:00:00

abstract：:The formation of a confluent endothelium on expanded polytetrafluoroethylene (PTFE) vascular prostheses has never been observed. This lack of endothelialization is known to be one of the main reasons leading to the development of thromboses and/or intimal hyperplasia. In this context, several efforts were put forward ...

journal_title：Biomaterials

authors： Crombez M,Chevallier P,-Gaudreault RC,Petitclerc E,Mantovani D,Laroche G

更新日期：2005-12-01 00:00:00

abstract：:Sintered bovine cancellous bone exhibited excellent biocompatiblity, high porosity and have an interconnecting porous structure allowing for bone ingrowth. However, the main mineral constitution of sintered bovine bone-hydroxyapatite (Ca10(PO4)6(OH)2, HAP) seems to be too stable in vivo. For improving its bioactivity,...

journal_title：Biomaterials

authors： Lin FH,Liao CJ,Chen KS,Sun JS

更新日期：1999-03-01 00:00:00

abstract：:Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major component of the BBB, express tight junctions and efflux transporters which regulate paracellular and transcellular permeability. However, most existing models of BBB m...

journal_title：Biomaterials

authors： Linville RM,DeStefano JG,Sklar MB,Xu Z,Farrell AM,Bogorad MI,Chu C,Walczak P,Cheng L,Mahairaki V,Whartenby KA,Calabresi PA,Searson PC

更新日期：2019-01-01 00:00:00

abstract：:The ultimate goal of implantation of biomaterials in the skeleton is to reach full integration of the non-living implant with the living bone. The biomaterial can be used much as a bone graft, resorbing or dissolving as bone growth occurs, and the end result is a new remoulded bone. Calcium pyrophosphate, Ca2P2O7, is ...

journal_title：Biomaterials

authors： Lin FH,Lin CC,Lu CM,Liu HC,Sun JS,Wang CY

更新日期：1995-07-01 00:00:00

abstract：:The repair of spinal cord injury (SCI) highly relies on microenvironment remodeling and facilitating the recruitment and neuronal differentiation of endogenous stem/progenitor cells. Decellularized tissue matrices (DTMs) have shown their unique and beneficial characteristics in promoting neural tissue regeneration, es...

journal_title：Biomaterials

authors： Xu Y,Zhou J,Liu C,Zhang S,Gao F,Guo W,Sun X,Zhang C,Li H,Rao Z,Qiu S,Zhu Q,Liu X,Guo X,Shao Z,Bai Y,Zhang X,Quan D

更新日期：2021-01-01 00:00:00

abstract：:The therapeutic efficacy of nanoscale anticancer drug delivery systems is severely truncated by their low tumor-targetability and inefficient drug release at the target site. Here, we report the design and development of novel endosomal pH-activatable paclitaxel prodrug micelles based on hyaluronic acid-b-dendritic ol...

journal_title：Biomaterials

authors： Zhong Y,Goltsche K,Cheng L,Xie F,Meng F,Deng C,Zhong Z,Haag R

更新日期：2016-04-01 00:00:00

abstract：:Healing soft-tissue wounds with an irregular, complicated topography in a bleeding environment demands the development of a dressing that is wet-adhesive, haemostatic, and antibacterial. To meet this unmet demand, we designed a flexible nanosheet (~77 nm thick) made of two layers, one is the antibacterial and haemosta...

journal_title：Biomaterials

authors： Xuan C,Hao L,Liu X,Zhu Y,Yang H,Ren Y,Wang L,Fujie T,Wu H,Chen Y,Shi X,Mao C

更新日期：2020-09-01 00:00:00

abstract：:Cartilage engineering is one of the most challenging issue in regenerative medicine, due to its limited self-ability to repair. Here, we assessed engineering of cartilage tissue starting from human bone marrow (hBM) stem cells under hypoxic environment and delineated the mechanism whereby chondrogenesis could be condu...

journal_title：Biomaterials

authors： Duval E,Baugé C,Andriamanalijaona R,Bénateau H,Leclercq S,Dutoit S,Poulain L,Galéra P,Boumédiene K

更新日期：2012-09-01 00:00:00

abstract：:In this work, we designed and synthesized an all-in-one zwitterionic material (poly2-((2-hydroxyethyl)(2-methacrylamidoethyl)(methyl)ammonio)acetate (pCBMAA-1)) bearing elasticity, switchable antimicrobial/antifouling properties, and stability. Zwitterionic materials have drawn special attention due to their outstandi...

journal_title：Biomaterials

authors： Cao B,Li L,Tang Q,Cheng G

更新日期：2013-10-01 00:00:00

abstract：:Study of axonal growth and ligand-receptor interactions requires specificity and careful characterization of the biomaterial substrates to which the neurons bind. It would be impossible to predict the effects of important variables such as composition, surface density, spatial distribution, and conformation of the lig...

journal_title：Biomaterials

authors： Zhang Z,Yoo R,Wells M,Beebe TP Jr,Biran R,Tresco P

更新日期：2005-01-01 00:00:00

abstract：:The synthesis of poly(lactic acid) through polycondensation of the lactic acid monomer gave weight average molecular weights (Mw) lower than 1.6 x 10(4), whereas ring-opening polymerization of lactides in bulk at 130 degrees C for 72 h using stannous octoate as catalyst in the concentration range from 0.003 to 0.8 wt%...

journal_title：Biomaterials

authors： Hyon SH,Jamshidi K,Ikada Y

更新日期：1997-11-01 00:00:00

abstract：:Multi-layered poly(glycerol-sebacate) (PGS) scaffolds with controlled pore microarchitectures were fabricated, combined with heart cells, and cultured with perfusion to engineer contractile cardiac muscle constructs. First, one-layered (1L) scaffolds with accordion-like honeycomb shaped pores and elastomeric mechanica...

journal_title：Biomaterials

authors： Park H,Larson BL,Guillemette MD,Jain SR,Hua C,Engelmayr GC Jr,Freed LE

更新日期：2011-03-01 00:00:00

abstract：:The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-...

journal_title：Biomaterials

authors： Yuan H,Li Y,de Bruijn JD,de Groot K,Zhang X

更新日期：2000-06-01 00:00:00

abstract：:Macropores in tissue engineering scaffolds provide space for vascularization, cell-proliferation and cellular interactions, and is crucial for successful tissue regeneration. Modulating the size and density of macropores may promote desirable cellular processes at different stages of tissue development. Most current t...

journal_title：Biomaterials

authors： Han LH,Lai JH,Yu S,Yang F

更新日期：2013-06-01 00:00:00

abstract：:IR-780 iodide is a near-infrared (NIR) fluorescence dye with higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG). Meanwhile, IR-780 can be utilized in photothermal therapy with laser irradiation. IR-780 is an important theranostic agent but its lipophilicity limited its ap...

journal_title：Biomaterials

authors： Yue C,Liu P,Zheng M,Zhao P,Wang Y,Ma Y,Cai L

更新日期：2013-09-01 00:00:00

abstract：:The initial stages of the in vitro degradation of and the drug release from a matrix made of poly(d,l-lactide-co-glycolide) was carried out in a phosphate buffer saline (pH 7.0) medium. It has been observed that substantial matrix degradation occurs at the end of 2 weeks of immersion. The drug release using films of t...

journal_title：Biomaterials

authors： Frank A,Kumar Rath S,Boey F,Venkatraman S

更新日期：2004-02-01 00:00:00

abstract：:Development of non-invasive assay for the accurate diagnosis of progressive liver diseases (e.g., fatty liver and hepatocellular carcinoma (HCC)) is of great clinical significance and remains to be a big challenge. Herein, we reported the synthesis of strawberry-like Fe3O4-Au hybrid nanoparticles at room temperature t...

journal_title：Biomaterials

authors： Zhao HY,Liu S,He J,Pan CC,Li H,Zhou ZY,Ding Y,Huo D,Hu Y

更新日期：2015-05-01 00:00:00

abstract：:In this study, the intra-articular tolerability and suitability for local and sustained release of an in situ forming gel composed of an acetyl-capped poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA-PEG-PCLA) copolymer loaded with celecoxib was investigated in horse join...

journal_title：Biomaterials

authors： Petit A,Redout EM,van de Lest CH,de Grauw JC,Müller B,Meyboom R,van Midwoud P,Vermonden T,Hennink WE,René van Weeren P

更新日期：2015-01-01 00:00:00

abstract：:Two vinyl sulfone functionalized crosslinkers were developed for the purpose of preparing degradable poly(ethylene glycol) (PEG) hydrogels (EMXL and GABA-EMXL hydrogels). A self-elimination degradation mechanism in which an N-terminal residue of a glutamine is converted to pyroglutamic acid with subsequent release of ...

journal_title：Biomaterials

authors： Deshmukh M,Singh Y,Gunaseelan S,Gao D,Stein S,Sinko PJ

更新日期：2010-09-01 00:00:00