Abstract：
BACKGROUND:Pancreatectomy can be complicated by pancreatic anastomotic leakage, causing major morbidity. STUDY DESIGN:Our aim was to determine if vapreotide, a potent long-acting somatostatin analogue, would decrease pancreas-related complications. This prospective, multicenter, randomized, double-blind, placebo-controlled trial involved 275 patients without preexisting chronic pancreatitis undergoing elective proximal, central, or distal pancreatectomy. Complications were defined by objective criteria before beginning the study. RESULTS:One hundred thirty-five patients received vapreotide; 140 patients received placebo. There were no statistically significant differences between vapreotide- and placebo-treated patients in either pancreas-related complications (30.4% versus 26.4%, respectively) or in other complications not directly related to the pancreas (40% versus 42%, respectively). CONCLUSIONS:The potent somatostatin analogue vapreotide does not appear to decrease postoperative complications after major pancreatectomy in patients without chronic pancreatitis.
journal_name
J Am Coll Surgjournal_title
Journal of the American College of Surgeonsauthors
Sarr MG,Pancreatic Surgery Group.doi
10.1016/S1072-7515(03)00104-2keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
556-64; discussion 564-5; author reply 565issue
4eissn
1072-7515issn
1879-1190pii
S1072-7515(03)00104-2journal_volume
196pub_type
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