Abstract:
OBJECTIVE:To evaluate the efficacy of ultra short-term antimicrobial prophylaxis with ceftazidime in patients undergoing radical gynecologic surgery. PATIENTS AND METHODS:Two hundred patients undergoing surgery for a malignant disease of the female genital tract were enrolled in a prospective trial to receive 2.0 g ceftazidime as a single dose, 30 minutes before induction of anaesthesia. After surgery, each patient was assessed to confirm febrile status and the presence of infections at the surgical site, urinary tract and respiratory tract. RESULTS:Postoperative morbidity occurred in 23 patients (11, 5%). Ten patients (5%) developed febrile morbidity, five (2, 5%) vaginal cuff infections, four asymptomatic bacteriuria and two each wound infiltration and urinary tract infection. Twelve patients had microbiological evidence of infection and Staphylococccus aureus was the most common pathogen isolated. Univariate analysis demonstrated that pre-existing systemic disease, extensive blood loss (more than 500 ml) and long duration of surgery (more than 150 minutes) were the only factors associated with a significant increase in postoperative febrile morbidity. CONCLUSIONS:Ultra short-term antimicrobial prophylaxis with ceftazidime is safe and effective in patients undergoing surgery for gynecologic cancer.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Cormio G,Di Fazio F,Di Gesù G,Scioscia M,Carriero C,Loverro G,Selvaggi Lkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
63-6issue
1eissn
0392-2936issn
2709-0086journal_volume
24pub_type
杂志文章abstract::It is difficult to find effective chemotherapy combination as third line treatment in epithelial ovarian cancer. In this paper the therapeutic response was evaluated of weekly administration of cis-platinum as third line chemotherapy, for a minimum of 6 cycles, on 8 patients, aged 41-72 years, with advanced ovarian ca...
journal_title:European journal of gynaecological oncology
pub_type: 临床试验,杂志文章
doi:
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abstract::Ductal carcinoma in situ (DCIS) represents a biologically and morphologically heterogeneous disease. It is characterized by a proliferation of presumably epithelial malignant cells confined within the lumens of the mammary ducts, without evidence of invasion beyond the basement membrane into the adjacent breast stroma...
journal_title:European journal of gynaecological oncology
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abstract::Malignant mixed mesodermal tumors (MMMTs) are highly aggressive and usually diagnosed at advanced stages. MMMT originates from either the ovary or the uterus. Because this disease is relatively rare, an optimal treatment modality has not yet been established. The authors report four cases of ovarian MMMT (one heterolo...
journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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