Metabolic phenotyping of the diseased rat heart using 13C-substrates and ex vivo perfusion in the working mode.

abstract：:Activating transcription factor 4 (ATF4), which is ubiquitously expressed, plays a crucial role in regulating various stress-responsive genes under pathophysiological conditions. Further, growth arrest and DNA damage-inducible gene 34 (GADD34), a downstream target of ATF4, has been reported to negatively regulate ATF4...

journal_title：Molecular and cellular biochemistry

authors： Oh-Hashi K,Sugiura N,Amaya F,Isobe KI,Hirata Y

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present investigation was to study the regulation of apolipoprotein E by two dietary nutrients, saturated fat and cholesterol, known to raise plasma cholesterol levels. ApoE is a protein component of several classes of lipoproteins including VLDL and HDL, and dietary lipids may regulate VLDL and apoE-co...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RA

更新日期：1996-02-23 00:00:00

abstract：:Cardiac oxidative stress is developed following myocardial infarction (MI) particularly in the first week of MI. The influence of reactive oxygen species (ROS) on gene expression profiling and molecular pathways in the infarcted myocardium remains uncertain and is explored in the present study. Rats with MI were treat...

journal_title：Molecular and cellular biochemistry

authors： Zhao W,Zhao T,Chen Y,Qu Y,Gerling IC,Sun Y

更新日期：2013-07-01 00:00:00

abstract：:To investigate whether the action potential duration (APD) or resting tension was dependent on global ATP content, and whether they were preferentially dependent on glycolytic ATP, APD and resting tension were measured under various metabolic inhibition with corresponding measurement of ATP content in guinea pig ventr...

journal_title：Molecular and cellular biochemistry

authors： Hayashi H,Terada H,McDonald TF

更新日期：1999-04-01 00:00:00

abstract：:A high molecular weight protein has been isolated as a major polypeptide comprising 85% of the total extractable proteins in the fruit pericarp of the plant Impatiens balsamina. The protein has been purified to homogeneity following fractionation of the crude cell supernatant with ammonium sulphate, chromatography on ...

journal_title：Molecular and cellular biochemistry

authors： Pal M,Biswas S

更新日期：1994-01-26 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-D is a crucial mediator of angiogenesis. Following myocardial infarction (MI), cardiac VEGF-D and VEGF receptor (VEGFR)-3 are significantly upregulated. In addition to endothelial cells, myofibroblasts at the site of MI highly express VEGFR-3, implicating the involvement of VE...

journal_title：Molecular and cellular biochemistry

authors： Zhao T,Zhao W,Meng W,Liu C,Chen Y,Bhattacharya SK,Sun Y

更新日期：2016-02-01 00:00:00

abstract：:Sialomucins are abundant on the surfaces of certain ascites tumor cells and have been implicated in the escape of tumors from immune destruction and metastasis. They are large, highly glycosylated glycoproteins which are rich in serine and threonine and have a variety of 0-linked oligosaccharides. The sialomucin (ASGP...

journal_title：Molecular and cellular biochemistry

authors： Carraway KL,Spielman J

更新日期：1986-11-01 00:00:00

abstract：:The present study was aimed to delineate in vivo mechanisms of orally administered fisetin with special reference to mitochondrial dysfunction in lung tissues employing benzo(a)pyrene (B(a)P) as the model lung carcinogen. The recent revival of interest in the study of mitochondria has been stimulated by the evidence t...

journal_title：Molecular and cellular biochemistry

authors： Ravichandran N,Suresh G,Ramesh B,Manikandan R,Choi YW,Vijaiyan Siva G

更新日期：2014-05-01 00:00:00

abstract：:A preparation of UDP-GalNAc:sialosyl lactosylceramide N-acetylgalactosaminyl transferase (E.C. 2.4.1.92) obtained from 14-day chick embryo brain was delipidated partially by treatment with cold acetone in the presence of varying amounts of sodium dodecyl sulphate (SDS). The lipid content and the enzyme activity of the...

journal_title：Molecular and cellular biochemistry

authors： Cortassa S,Maccioni HJ

更新日期：1989-01-23 00:00:00

abstract：:Many glomerular diseases are associated with changes in the expression and distribution in the components of extracellular matrix. A remarkable feature in acute renal failure induced by mercuric chloride in rats was large fibronectin (Fn) deposits in kidneys 1 h post-HgCl2 injection (5 mg/kg body wt., s.c.). Our study...

journal_title：Molecular and cellular biochemistry

authors： Saball E,Salvarrey M,Serra E,Picó G,Elías MM

更新日期：2001-10-01 00:00:00

abstract：:Progression of prostate cancer is facilitated by growth factors that activate critical signaling cascades thereby promote prostate cancer cell growth, survival, and migration. To investigate the effect of quercetin on insulin-like growth factor signaling and apoptosis in androgen independent prostate cancer cells (PC-...

journal_title：Molecular and cellular biochemistry

authors： Senthilkumar K,Elumalai P,Arunkumar R,Banudevi S,Gunadharini ND,Sharmila G,Selvakumar K,Arunakaran J

更新日期：2010-11-01 00:00:00

abstract：:Plexiform neurofibromas commonly found in patients with Neurofibromatosis type I (NF1) have a 5% risk of being transformed into malignant peripheral nerve sheath tumors (MPNST). Germline mutations in the NF1 gene coding for neurofibromin, which is a Ras GTPase activating protein (RasGAP) and a negative regulator of Ra...

journal_title：Molecular and cellular biochemistry

authors： Kraniak JM,Sun D,Mattingly RR,Reiners JJ Jr,Tainsky MA

更新日期：2010-11-01 00:00:00

abstract：:To examine the essential mechanisms of steroid production in ovarian theca cells, we analyzed the expression of genes associated with steroid production using simple culture system with serum medium. In addition, we examined the involvement of DAX-1, COUP-TFII, and Ad4BP/SF-1 transcription factors on the steroid produ...

journal_title：Molecular and cellular biochemistry

authors： Murayama C,Miyazaki H,Miyamoto A,Shimizu T

更新日期：2008-07-01 00:00:00

abstract：:The present study was designed to evaluate the in vitro and in vivo ameliorative antioxidant potential of secoisolariciresinol diglucoside (SDG). In vitro antioxidant activity of synthetic SDG was carried out using DPPH, reducing power potency, and DNA protection assays. Wistar albino rats weighing 180-220 g were used...

journal_title：Molecular and cellular biochemistry

authors： Moree SS,Rajesha J

更新日期：2013-01-01 00:00:00

abstract：:Increasing evidence has shown that normal stem cells may act as cancer-initiating cells and contribute to the development and progression of cancer. HBx has a close relationship with hepatocellular carcinoma, however, the role of HBx in hepatic progenitor cells (HPCs) is poorly understood. In this study, we sought to ...

journal_title：Molecular and cellular biochemistry

authors： Shen L,Zhang X,Hu D,Feng T,Li H,Lu Y,Huang J

更新日期：2013-11-01 00:00:00

abstract：:Long-chain fatty acids (e.g. arachidonic acid) have been implicated in physiological control of insulin secretion. We previously reported histidine phosphorylation of at least two islet proteins (e.g., NDP kinase and the beta subunit of trimeric G-proteins), and suggested that such a signalling step may have regulator...

journal_title：Molecular and cellular biochemistry

authors： Kowluru A

更新日期：2004-11-01 00:00:00

abstract：:Acanthamoeba rRNA transcription involves the binding of a transcription initiation factor (TIF) to the core promoter of rDNA to form the preinitiation complex. This complex is formed in the absence of RNA polymerase I, and persists for multiple rounds of initiation. Polymerase I next binds to form the initiation compl...

journal_title：Molecular and cellular biochemistry

authors： Paule MR,Bateman E,Hoffman L,Iida C,Imboden M,Kubaska W,Kownin P,Li H,Lofquist A,Risi P

更新日期：1991-05-29 00:00:00

abstract：:The role of glycogen content in the heart for the development of isoprenaline-induced myocardial lesions (IML) was studied in Wistar rats and in two inbred rat strains: In IR rats (resistant to the development of IML) and in IS rats (sensitive to IML development). Glycogen content in the heart can be dramatically lowe...

journal_title：Molecular and cellular biochemistry

authors： Mráz M,Hynie S

更新日期：1996-10-01 00:00:00

abstract：:The interaction of immune cells with endothelial and target cells and extracellular matrix in human organ transplants is regulated by a number of receptor-ligand molecules. The molecules mediating intercellular adhesion and activation are classified as integrin, immunoglobulin and selectin families. In the present stu...

journal_title：Molecular and cellular biochemistry

authors： Steinhoff G,Haverich A

更新日期：1995-06-07 00:00:00

abstract：:Whereas in rat liver mitochondria the hyperthyroid state causes an increase both in fatty acid unsaturation and in the Ea of D-3-hydroxybutyrate dehydrogenase and a decrease in phase transition temperature, in hyperthyroid rat heart mitochondria these changes are negligible. D-3-hydroxybutyrate dehydrogenase in both t...

journal_title：Molecular and cellular biochemistry

authors： Lippolis R,Morini P,Conserva AR,Casalino E,Landriscina C

更新日期：1990-03-27 00:00:00

abstract：:Nicotinic acid administration, which depletes liver glycogen, leads to an increase of both pyruvate kinase L and phosphoenolypyruvate carboxykinase in liver by a factor of nearly two. The former is not prevented by either cycloheximide or actinomycin D. L-Cysteine, an allosteric inhibitor of pyruvate kinase L, favors ...

journal_title：Molecular and cellular biochemistry

authors： Moreno FJ,Benito M,Sánchez-Medina F,Medina JM,Mayor F

更新日期：1976-11-30 00:00:00

abstract：:CDK11(p58), a G2/M-specific protein kinase, has been shown to be associated with apoptosis in many cell lines, with largely unknown mechanisms. Our previous study proved that CDK11(p58)-enhanced cycloheximide (CHX)-induced apoptosis in SMMC-7721 hepatocarcinoma cells. Here we report for the first time that ectopic exp...

journal_title：Molecular and cellular biochemistry

authors： Yun X,Wu Y,Yao L,Zong H,Hong Y,Jiang J,Yang J,Zhang Z,Gu J

更新日期：2007-10-01 00:00:00

abstract：:The aim of the present study was to determine whether heat shock protein 72 (HSP72) is induced in a heated rat model at rectal temperatures below 42 degrees C. Rats were divided into a control group and six groups (n = 6) heated to different rectal temperatures: 39 degrees C for 1 h (39), 40.0 degrees C for either 15 ...

journal_title：Molecular and cellular biochemistry

authors： Ruell PA,Hoffman KM,Chow CM,Thompson MW

更新日期：2004-12-01 00:00:00

abstract：:The reversal effect of troxerutin (TX) on obesity, insulin resistance, lipid accumulation, oxidative damage, and hypertension induced in the high-fat-high-fructose diet (HFFD)-fed mice model of metabolic syndrome was investigated. Adult male Mus musculus mice of body weight 25-30 g were fed either control diet or HFFD...

journal_title：Molecular and cellular biochemistry

authors： Geetha R,Yogalakshmi B,Sreeja S,Bhavani K,Anuradha CV

更新日期：2014-02-01 00:00:00

abstract：:Glycosaminoglycans were extracted from normal, inflamed and phenytoin induced overgrowth of human gingival tissue by proteolysis and alcohol precipitation. Extracts were run in a Dowex-1 column and the fractions were treated with mucopolysaccharidases. Cellulose acetate electrophoresis was carried out with or without ...

journal_title：Molecular and cellular biochemistry

authors： Suresh R,Puvanakrishnan R,Dhar SC

更新日期：1992-10-07 00:00:00

abstract：:This article is a review on the organization and function of myofibrillar creatine kinase in striated muscle. The first part describes myofibrillar creatine kinase as an integral structural part of the complex organization of myofibrils in striated muscle. The second part considers the intrinsic biochemical and mechan...

journal_title：Molecular and cellular biochemistry

authors： Ventura-Clapier R,Veksler V,Hoerter JA

更新日期：1994-04-01 00:00:00

abstract：:Evidence suggests that endothelial cell layer heparan sulfate proteoglycans include a variety of different sized molecules which most likely contain different protein cores. In the present report, approximately half of endothelial cell surface associated heparan sulfate proteoglycan is shown to be releasable with solu...

journal_title：Molecular and cellular biochemistry

authors： Lowe-Krentz LJ,Thompson K,Patton WA 2nd

更新日期：1992-01-15 00:00:00

abstract：:Stress genes can be ascribed to have been generated by the organism for their intrinsic urge to survive against the changing environmental odds, during the evolutionary process. This concept has been supported by a large number of reports describing individual types of phenomena. These have been reconciled and globali...

journal_title：Molecular and cellular biochemistry

authors： Ray PK

更新日期：1999-06-01 00:00:00

abstract：:Effect of several vanadium salts, sodium orthovanadate, vanadyl sulfate and sodium metavanadate on protein tyrosine phosphorylation and serine/threonine kinases in chinese hamster ovary (CHO) cells overexpressing a normal human insulin receptor was examined. All the compounds stimulated protein tyrosine phosphorylatio...

journal_title：Molecular and cellular biochemistry

authors： Pandey SK,Chiasson JL,Srivastava AK

更新日期：1995-12-06 00:00:00

abstract：:NF45, also referred to as nuclear factor of activated T cells, has been reported to promote the progression of multiple cancer types. However, the expression and physiological significance of NF45 in pancreatic ductal adenocarcinoma (PDAC) remain largely elusive. In this study, we investigated the clinical relevance a...

journal_title：Molecular and cellular biochemistry

authors： Wan C,Gong C,Ji L,Liu X,Wang Y,Wang L,Shao M,Yang L,Fan S,Xiao Y,Wang X,Li M,Zhou G,Zhang Y

更新日期：2015-12-01 00:00:00